{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:37:31Z","timestamp":1781642251796,"version":"3.54.5"},"reference-count":156,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Each year approximately 2400 pregnancies develop folic acid-preventable spina bifida and anencephaly in Europe. Currently, 70% of all affected pregnancies are terminated after prenatal diagnosis. The prevalence of neural tube defects (NTDs) has been significantly lowered in more than 70 countries worldwide by applying fortification with folic acid. Periconceptional supplementation of folic acid also reduces the risk of congenital heart diseases, preterm birth, low birth weight, and health problems associated with child mortality and morbidity. All European governments failed to issue folic acid fortification of centrally processed and widely eaten foods in order to prevent NTDs and other unwanted birth outcomes. The estimated average dietary intake of folate in Germany is 200 \u03bcg dietary folate equivalents (DFE)\/day. More than half of German women of reproductive age do not consume sufficient dietary folate to achieve optimal serum or red blood cell folate concentrations (&gt;18 or 1000 nmol\/L, respectively) necessary to prevent spina bifida and anencephaly. To date, targeted supplementation is recommended in Europe, but this approach failed to reduce the rate of NTDs during the last 10 years. Public health centers for prenatal care and fortification with folic acid in Europe are urgently needed. Only such an action will sufficiently improve folate status, prevent at least 50% of the NTD cases, reduce child mortality and morbidity, and alleviate other health problems associated with low folate such as anemia.<\/jats:p>","DOI":"10.1515\/jpm-2014-0346","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T03:24:36Z","timestamp":1427858676000},"source":"Crossref","is-referenced-by-count":30,"title":["Folate status and health: challenges and 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reproductive age, pregnant and lactating women: a meta-analysis","volume":"2012","year":"2012","journal-title":"J Nutr Metab"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"9523","DOI":"10.1073\/pnas.1301816110","article-title":"Preventing Alzheimer\u2019s disease-related gray matter atrophy by B-vitamin treatment","volume":"110","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-277X.2011.01216.x","article-title":"Uptake of folic acid supplements before and during pregnancy: focus group analysis of women\u2019s views and experiences","volume":"25","year":"2012","journal-title":"J Hum Nutr Diet"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"e12244","DOI":"10.1371\/journal.pone.0012244","article-title":"Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial","volume":"5","year":"2010","journal-title":"PLoS ONE"},{"key":"ref1591","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejogrb.2011.12.019","article-title":"Experience of the Hungarian Preconception Service between 1984 and 2010","volume":"161","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref791","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3945\/jn.111.156919","article-title":"Estimation of trends in serum and RBC folate in the U.S. population from pre- to postfortification using assay-adjusted data from the NHANES 1988\u20132010","volume":"142","year":"2012","journal-title":"J Nutr"},{"key":"ref1251","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3945\/jn.109.118075","article-title":"Higher maternal plasma folate but not vitamin B-12 concentrations during pregnancy are associated with better cognitive function scores in 9- to 10-year-old children in South India","volume":"140","year":"2010","journal-title":"J Nutr"},{"key":"ref911","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.clnu.2013.12.013","article-title":"Critical evaluation of lowering the recommended dietary intake of folate","volume":"33","year":"2014","journal-title":"Clin Nutr"},{"key":"ref671","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0140-6736(12)62001-7","article-title":"Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals","volume":"381","year":"2013","journal-title":"Lancet"},{"key":"ref1101","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ypmed.2013.02.019","article-title":"The association between periconceptional folic acid supplementation and congenital heart defects: a case-control study in China","volume":"56","year":"2013","journal-title":"Prev 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disorders","year":"2010","journal-title":"Int J Epidemiol"},{"key":"ref111","first-page":"6","article-title":"The cost of preventable conditions in adults with spina bifida","year":"1996","journal-title":"Eur J Pediatr Surg"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3945\/ajcn.111.030791","article-title":"Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study","volume":"95","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"ref1171","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00394-012-0339-z","article-title":"The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study)","volume":"52","year":"2013","journal-title":"Eur J 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Nutr"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1096-8628(19960315)62:2<179::AID-AJMG12>3.0.CO;2-L","article-title":"Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation","volume":"62","year":"1996","journal-title":"Am J Med Genet"},{"key":"ref921","doi-asserted-by":"crossref","first-page":"1222002","DOI":"10.1126\/science.1222002","article-title":"The continuing challenge of understanding, preventing, and treating neural tube defects","volume":"339","year":"2013","journal-title":"Science"},{"key":"ref1551","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3945\/ajcn.2008.26568","article-title":"Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk","volume":"89","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"ref661","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3945\/ajcn.113.076349","article-title":"Effects of 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neural tube defects: a meta-analysis of the published literature","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"ref1441","doi-asserted-by":"crossref","first-page":"9523","DOI":"10.1073\/pnas.1301816110","article-title":"Preventing Alzheimer\u2019s disease-related gray matter atrophy by B-vitamin treatment","volume":"110","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref831","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/ajcn\/88.2.448","article-title":"Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial","volume":"88","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2796.2011.02484.x","article-title":"Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study","volume":"271","year":"2012","journal-title":"J Intern Med"},{"key":"ref1211","first-page":"45","article-title":"Folic acid supplementation in early second trimester and the risk of preeclampsia","volume":"198","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1471-0528.2012.03321.x","article-title":"Homocysteine and folate concentrations in early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study","volume":"119","year":"2012","journal-title":"Br J Obstet Gynecol"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3945\/ajcn.110.002659","article-title":"Pre- and postfortification intake of folate and risk of colorectal cancer in a large prospective cohort study in the United States","volume":"94","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"ref1501","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0140-6736(12)62001-7","article-title":"Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals","volume":"381","year":"2013","journal-title":"Lancet"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.clnu.2013.12.013","article-title":"Critical evaluation of lowering the recommended dietary intake of folate","volume":"33","year":"2014","journal-title":"Clin Nutr"},{"key":"ref1261","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-3016.2009.01032.x","article-title":"Maternal use of folic acid supplements during pregnancy and four-year-old neurodevelopment in a population-based birth cohort","volume":"23","year":"2009","journal-title":"Paediatr Perinat Epidemiol"},{"key":"ref561","article-title":"CSPPT Investigators. Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China: The CSPPT Randomized Clinical Trial","year":"In press","journal-title":"J Am Med Assoc"},{"key":"ref1131","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/ajmg.1320590428","article-title":"Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring","volume":"59","year":"1995","journal-title":"Am J Med Genet"},{"key":"ref1091","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/eurheartj\/ehp479","article-title":"Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands","volume":"31","year":"2010","journal-title":"Eur Heart J"},{"key":"ref1141","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/bdra.23224","article-title":"One-carbon metabolite levels in 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autism","volume":"22","year":"2011","journal-title":"Epidemiology"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1373\/clinchem.2007.100214","article-title":"Trends in circulating concentrations of total homocysteine among US adolescents and adults: findings from the 1991\u20131994 and 1999\u20132004 National Health and Nutrition Examination Surveys","volume":"54","year":"2008","journal-title":"Clin Chem"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10995-014-1542-8","article-title":"Neural tube defects in Costa Rica, 1987\u20132012: origins and development of birth defect surveillance and folic acid fortification","volume":"19","year":"2015","journal-title":"Matern Child Health J"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"b1673","DOI":"10.1136\/bmj.b1673","article-title":"Prevalence of severe congenital heart disease after folic acid fortification of grain products: time trend analysis in Quebec, Canada","volume":"338","year":"2009","journal-title":"BMJ"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/pubmed\/fdr048","article-title":"Factors contributing to the success of folic acid public health campaigns","volume":"34","year":"2012","journal-title":"J Public Health (Oxf)"},{"key":"ref1231","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1093\/jn\/136.10.2617","article-title":"Milk folate secretion is not impaired during iron deficiency in humans","volume":"136","year":"2006","journal-title":"J Nutr"},{"key":"ref891","first-page":"470656","article-title":"Folate intake and markers of folate status in women of reproductive age, pregnant and lactating women: a meta-analysis","volume":"2012","year":"2012","journal-title":"J Nutr Metab"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1016\/j.neurobiolaging.2014.01.154","article-title":"Higher homocysteine associated with thinner cortical gray matter in 803 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