{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T19:02:17Z","timestamp":1743534137889},"reference-count":62,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our aim was to determine whether maternal HIV infection in the current era is associated with an increased incidence of meconium aspiration syndrome (MAS) in their infants.<\/jats:p><jats:p>Infants born to 149 HIV-positive women at our hospital over a 5-year period were compared with infants born to HIV-negative women in a retrospective case-control study. Charts of all 298 patients included in the study were reviewed for maternal and infant demographics, HIV treatment, vertical transmission and untoward events at delivery or during the hospital course.<\/jats:p><jats:p>When compared with HIV-negative women, a greater proportion of HIV-positive women had meconium-stained amniotic fluid (MSAF), 33% vs. 13%, P&lt;0.001; and thick MSAF, 17% vs. 5%, P&lt;0.001, respectively. Seven of 298 infants were admitted to the neonatal intensive care unit for MAS; all seven were born to HIV-positive women (P=0.015). Although<\/jats:p><jats:p>Infants born to HIV-positive women had significantly more MSAF and MAS than infants born to non-infected women. It is unclear whether this association results from maternal HIV infection itself or from anti-retroviral therapy. Maternal and infant care providers should be prepared for this complication when attending to the deliveries of HIV-positive women.<\/jats:p>","DOI":"10.1515\/jpm-2014-0377","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T11:22:57Z","timestamp":1432293777000},"source":"Crossref","is-referenced-by-count":1,"title":["Meconium aspiration syndrome in infants of HIV-positive women: a case-control study"],"prefix":"10.1515","volume":"44","author":[{"given":"Sachin K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pam","family":"Haerr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suma","family":"Pyati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref481","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1203\/pdr.0b013e31802d8a81","article-title":"Elevated plasma corticotrophin release factor levels and in utero meconium passage","volume":"61","year":"2007","journal-title":"Pediatr Res."},{"key":"ref261","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/08998280.2009.11928491","article-title":"Prevention of meconium aspiration syndrome: an update and the Baylor experience","volume":"22","year":"2009","journal-title":"Proc (Bayl Univ Med Cent)."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1080\/08035250510042951","article-title":"Hematological parameters of HIV-1-uninfected infants born to HIV-1 infected mothers","volume":"94","year":"2005","journal-title":"Acta Paediatr."},{"key":"ref531","first-page":"1640","volume-title":"Goodman & Gilman\u2019s the pharmacological basis of therapeutics","year":"2011"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/QAD.0b013e3280d5a786","article-title":"In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected children","volume":"21","year":"2007","journal-title":"AIDS."},{"key":"ref101","first-page":"157","article-title":"Cocaine abuse during pregnancy: maternal and fetal implications","volume":"73","year":"1989","journal-title":"Obstet Gynecol."},{"key":"ref411","first-page":"1157","volume-title":"Fanaroff and Martin\u2019s neonatal-perinatal medicine","year":"2011"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/aje\/kwg074","article-title":"Estimating the relative risk in cohort studies and clinical trials of common outcomes","volume":"157","year":"2003","journal-title":"Am J Epidemiol."},{"key":"ref181","first-page":"2508","volume-title":"Harrison\u2019s principles of internal medicine","year":"2005"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0378-3782(77)90017-2","article-title":"The narcotic-dependent mother: fetal and neonatal consequences","volume":"1","year":"1977","journal-title":"Early Hum Dev."},{"key":"ref511","first-page":"2508","volume-title":"Harrison\u2019s principles of internal medicine","year":"2005"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/INF.0b013e31812f56ed","article-title":"Maternal antiretrovirals and hepatic enzyme, hematologic abnormalities among human immunodeficiency virus type 1-uninfected infants. 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