{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T12:48:00Z","timestamp":1742388480063},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study is designed to evaluate predictive value of first-trimester cystatin C levels for long-term pregnancy complications.<\/jats:p><jats:p>The cross-sectional study population consisted of patients who admitted to outpatient clinic of a Maternity Hospital between September 2013 and December 2014. Among the 203 participants who accepted to participate in the study, 174 subjects who continued antenatal follow-up in the same clinic were included in the final analyses. Cystatin C, blood urea nitrogen, Creatinine levels and estimated glomerular filtration rates were evaluated in the first-trimester routine antenatal visit. Mode of delivery and gestational complications were noted.<\/jats:p><jats:p>First-trimester cystatin C levels were significantly higher in cases complicated with preterm delivery and premature rupture of membrane (PROM) compared to uncomplicated ones (0.58\u00b10.07 vs. 0.55\u00b10.07, P=0.041, and 0.58\u00b10.07 vs. 0.55\u00b10.07, P=0.036). With a cutoff value of 0.505 mg\/L, sensitivity of cystatin C for preterm delivery and PROM was 91.9% and specificity was 27.7% with a negative predictive value of 92.3% and a positive predictive value of 26.6%.<\/jats:p><jats:p>Detection of cystatin C levels in the first trimester of pregnancy for the prediction of preterm\/PROM seems as a promising preliminary data. The relatively higher first-trimester cystatin C levels in complicated pregnancies are conspicuous. The results imply that in pregnancy cystatin C might be more than a marker for renal function.<\/jats:p>","DOI":"10.1515\/jpm-2015-0061","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T02:38:56Z","timestamp":1441939136000},"source":"Crossref","is-referenced-by-count":4,"title":["The prognostic value of first-trimester cystatin C levels for gestational complications"],"prefix":"10.1515","volume":"44","author":[{"given":"Asl\u0131 Yarc\u0131","family":"Gursoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Tasci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Celik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze 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