{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:00:18Z","timestamp":1762210818173},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preterm birth (PTB) is a predictor of perinatal morbidity and mortality, and prematurity continues to burden public healthcare with growing expenses. First trimester bleeding (FTB) has a well-known association with PTB; however, the relationship with severity of PTB is less obvious.<\/jats:p><jats:p>The primary aim of the study was to analyze the influence of FTB on the risk and severity of PTB, as well as to assess the connection of FTB and other pregnancy complications.<\/jats:p><jats:p>It was an observational case control study. The material consisted of medical records of patients who delivered between 2010 and 2013. Two groups were formed \u2013 497 women with FTB and 500 women without bleeding.<\/jats:p><jats:p>Women with FTB were more likely to deliver preterm in general (OR=2.11; 95% CI 1.43\u20133.10). The risk of extremely PTB (&lt;28 weeks) was almost four-fold (OR=3.76; 95% CI 0.97\u201317.06) and very PTB (28\u201331 weeks) more than three-fold (OR=3.41; 95% CI 0.86\u201315.69). FTB increased the risk of placenta previa (OR=4.81; 95% CI 1.29\u201320.53; P=0.007).<\/jats:p><jats:p>FTB is a risk factor of PTB and is associated with greater risk of PTB-related pregnancy complications. Management of FTB pregnancies should include thorough screening for both preterm delivery and placental pathologies.<\/jats:p>","DOI":"10.1515\/jpm-2015-0063","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T10:16:36Z","timestamp":1441880196000},"source":"Crossref","is-referenced-by-count":4,"title":["The association of first trimester bleeding with preterm delivery"],"prefix":"10.1515","volume":"43","author":[{"given":"Iwona","family":"Szymusik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Bartnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudia","family":"Wypych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halszka","family":"Kolaczkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kosinska-Kaczynska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslaw","family":"Wielgos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref241","first-page":"190","article-title":"FASTER Consortium Threatened abortion : a risk factor for poor pregnancy outcome a population - based screening study","author":"Weiss","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"ref281","first-page":"18","article-title":"Idiopathic vaginal bleeding during pregnancy as the only clinical manifestation of intrauterine infection Fetal Neonatal","author":"G\u00f3mez","year":"2005","journal-title":"Med"},{"key":"ref21","first-page":"135","article-title":"Risk of preterm delivery in relation to vaginal bleeding in early pregnancy","author":"Hossain","year":"2007","journal-title":"Eur Obstet Gynecol Reprod Biol"},{"key":"ref171","first-page":"107","article-title":"Threatened miscarriage as a predictor of obstetric outcome","author":"Johns","year":"2006","journal-title":"Obstet Gynecol"},{"key":"ref91","first-page":"34","article-title":"Does inflammation contribute to thrombotic events","volume":"30","author":"Esmon","year":"2000","journal-title":"Haemostasis"},{"key":"ref381","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/del054","article-title":"De der First - trimester bleeding and pregnancy outcome in singletons after assisted reproduction","volume":"21","author":"Sutter","year":"2006","journal-title":"Hum Reprod"},{"key":"ref61","first-page":"99","article-title":"Von Perinatal outcome of pregnancies complicated by vaginal bleeding","author":"Sipil\u00e4","year":"1992","journal-title":"J Obstet Gynaecol"},{"key":"ref391","first-page":"115","article-title":"First - 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control report Fetal Neonatal ahead of print","author":"Ozdemirci","year":"2014","journal-title":"Med"},{"key":"ref181","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/del054","article-title":"De der First - trimester bleeding and pregnancy outcome in singletons after assisted reproduction","volume":"21","author":"Sutter","year":"2006","journal-title":"Hum Reprod"},{"key":"ref161","first-page":"160","article-title":"Vaginal bleeding during pregnancy and preterm birth","volume":"25","author":"Yang","year":"2004","journal-title":"Am J Epidemiol"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/jp.2014.74","article-title":"Perinatal outcomes in singleton and twin pregnancies following first - trimester bleeding","author":"Lucovnik","year":"2014","journal-title":"J Perinatol"},{"key":"ref221","first-page":"135","article-title":"Risk of preterm delivery in relation to vaginal bleeding in early pregnancy","author":"Hossain","year":"2007","journal-title":"Eur Obstet Gynecol Reprod Biol"},{"key":"ref101","first-page":"185","article-title":"The role of thrombin in preterm parturition","author":"Elovitz MA","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"ref371","first-page":"107","article-title":"Threatened miscarriage as a predictor of obstetric outcome","author":"Johns","year":"2006","journal-title":"Obstet Gynecol"},{"key":"ref111","first-page":"301","article-title":"First trimester vaginal bleeding and adverse pregnancy outcomes among Chinese women : from a large cohort study in China Fetal Neonatal","volume":"25","author":"Sun","year":"2012","journal-title":"J Med"},{"key":"ref151","first-page":"107","article-title":"Obstetric outcome in women with threatened miscarriage in the first trimester","author":"Wijesiriwardana","year":"2006","journal-title":"Obstet Gynecol"},{"key":"ref361","first-page":"160","article-title":"Vaginal bleeding during pregnancy and preterm birth","volume":"25","author":"Yang","year":"2004","journal-title":"Am J Epidemiol"},{"key":"ref131","first-page":"1","article-title":"Influence of threatened miscarriage on pregnancy and early postpartum period : a case - 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