{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:09:44Z","timestamp":1787022584743,"version":"build-2736575974"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate the possible effect of abnormal placentation disorders such as preeclampsia (PE), pregnancy induced hypertension (PIH) and intrauterine growth restriction (IUGR) on erythropoietin (EPO) serum concentration in women in the first trimester of pregnancy.<\/jats:p>\n                  <jats:p>A prospective study was performed in a group of pregnant women between 11 and 13<\/jats:p>\n                  <jats:p>A group of 198 analyzed patients was divided into three groups depending on pregnancy outcome: abnormal placentation group (n=30), macrosomia (n=13) and control group (n=155). EPO concentrations between the three groups of patients revealed that they differ significantly (F=15.172, P&lt;0.001). EPO concentration is significantly higher in abnormal placentation patients compared to the control group (P&lt;0.001) and macrosomia group (P=0.004). The most significant increase in EPO concentration was detected within patients with PIH. Also the uterine artery pulsatility index was positively correlated with EPO concentration (P&lt;0.01).<\/jats:p>\n                  <jats:p>First-trimester maternal EPO concentration might be considered as a possible marker of abnormal placentation disorders and should be given more attention in future prospective studies.<\/jats:p>","DOI":"10.1515\/jpm-2015-0079","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T13:01:24Z","timestamp":1430744484000},"source":"Crossref","is-referenced-by-count":5,"title":["First trimester erythropoietin (EPO) serum concentration as a potential marker for abnormal placentation disorders. Reference values for erythropoietin (EPO) concentration at 11\u201313+6 weeks of gestation"],"prefix":"10.1515","volume":"44","author":[{"given":"Przemys\u0142aw","family":"Kosi\u0144ski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota A.","family":"Bomba-Opo\u0144","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142aw","family":"Wielgo\u015b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref341","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1034\/j.1600-0609.2003.00085.x","article-title":"Haemoglobin during pregnancy : relationship to erythropoietin and haematinic status","volume":"71","author":"McMullin","year":"2003","journal-title":"Eur J Haematol"},{"key":"ref381","first-page":"196","article-title":"The relationship between human fetal cardiovascular hemodynamics and serum erythropoietin levels in growth - restricted fetuses","author":"Girsen","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref351","first-page":"106","article-title":"Expression of erythropoietin in human female reproductive organs","volume":"22","author":"Yasuda","year":"2001","journal-title":"J Anat Embryol"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000324320","article-title":"Turning the pyramid of prenatal care","volume":"29","author":"Nicolaides","year":"2011","journal-title":"Fetal Diagn Ther"},{"key":"ref31","first-page":"11","article-title":"Prediction of early intermediate and late pre - eclampsia from maternal factors biophysical and biochemical markers at weeks","author":"Akolekar","year":"2011"},{"key":"ref301","first-page":"273","article-title":"concentration among patients with and without preeclampsia","author":"Hershkovitz","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"ref401","first-page":"795","article-title":"in preeclampsia","author":"Kaupke","year":"1991","journal-title":"Obstet Gynecol"},{"key":"ref171","first-page":"196","article-title":"The relationship between human fetal cardiovascular hemodynamics and serum erythropoietin levels in growth - restricted fetuses","author":"Girsen","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/00365519409087546","article-title":"Serum concentrations of erythropoietin in healthy and anaemic pregnant women","author":"Riikonen","year":"1994","journal-title":"Clin Lab Invest"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/00365519409087546","article-title":"Serum concentrations of erythropoietin in healthy and anaemic pregnant women","author":"Riikonen","year":"1994","journal-title":"Clin Lab Invest"},{"key":"ref61","first-page":"85","article-title":"the HIF system in kidney disease","volume":"30","author":"Nangaku","year":"2007","journal-title":"Hypoxia J Mol Med"},{"key":"ref391","first-page":"182","article-title":"Obstetric conditions erythropoietin levels","author":"Goldstein","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"ref411","first-page":"11","article-title":"Reference values for placental growth factor PlGF concentration and uterine artery doppler pulsatility index PI at weeks of gestation in the Polish population","author":"Kosinski","year":"2014","journal-title":"Ginekol Pol"},{"key":"ref221","first-page":"85","article-title":"Non - invasive prenatal diagnosis of the most common aneuploidies with cell - free fetal DNA in maternal serum preliminary results ] Nieinwazyjna diagnostyka prenatalna najczestszych aneuploidii na podstawie plodowego DNA we krwi matki doniesienie wstepne","volume":"13","author":"Bijok","year":"2014","journal-title":"Ginekol Pol"},{"key":"ref271","first-page":"85","article-title":"the HIF system in kidney disease","volume":"30","author":"Nangaku","year":"2007","journal-title":"Hypoxia J Mol Med"},{"key":"ref331","first-page":"270","article-title":"KT The role and regulation of secretion of erythropoietin in pregnancy Medycyna wieku rozwojowego","volume":"17","author":"Kowalska","year":"2013"},{"key":"ref321","first-page":"7","article-title":"Fetal and maternal erythropoietin levels in normal pregnancy","volume":"21","author":"Ireland","year":"1992","journal-title":"Fetal Diagn Ther"},{"key":"ref191","first-page":"795","article-title":"in preeclampsia","author":"Kaupke","year":"1991","journal-title":"Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000324320","article-title":"Turning the pyramid of prenatal care","volume":"29","author":"Nicolaides","year":"2011","journal-title":"Fetal Diagn Ther"},{"key":"ref91","first-page":"273","article-title":"concentration among patients with and without preeclampsia","author":"Hershkovitz","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"ref11","first-page":"85","article-title":"Non - invasive prenatal diagnosis of the most common aneuploidies with cell - free fetal DNA in maternal serum preliminary results ] Nieinwazyjna diagnostyka prenatalna najczestszych aneuploidii na podstawie plodowego DNA we krwi matki doniesienie wstepne","volume":"13","author":"Bijok","year":"2014","journal-title":"Ginekol Pol"},{"key":"ref311","first-page":"545","article-title":"Serum immunoreactive erythropoietin during pregnancy and in the early postpartum","author":"Beguin","year":"1990"},{"key":"ref141","first-page":"106","article-title":"Expression of erythropoietin in human female reproductive organs","volume":"22","author":"Yasuda","year":"2001","journal-title":"J Anat Embryol"},{"key":"ref151","first-page":"23","article-title":"Lack of permeability of the human placenta for erythropoietin","author":"Schneider","year":"1995","journal-title":"J Perinat Med"},{"key":"ref211","first-page":"11","article-title":"Maternal plasma cell - free fetal and maternal DNA at weeks gestation : relation to fetal and maternal characteristics and pregnancy outcomes","volume":"23","author":"Poon","year":"2013","journal-title":"Fetal Diagn Ther"},{"key":"ref201","first-page":"11","article-title":"Reference values for placental growth factor PlGF concentration and uterine artery doppler pulsatility index PI at weeks of gestation in the Polish population","author":"Kosinski","year":"2014","journal-title":"Ginekol Pol"},{"key":"ref251","article-title":"Early administration of low - dose aspirin for the prevention of severe and mild preeclampsia : a systematic review and meta - analysis","volume":"31","author":"Roberge","year":"2014","journal-title":"Am J Perinatol"},{"key":"ref241","first-page":"11","article-title":"Prediction of early intermediate and late pre - eclampsia from maternal factors biophysical and biochemical markers at weeks","author":"Akolekar","year":"2011"},{"key":"ref181","first-page":"182","article-title":"Obstetric conditions erythropoietin levels","author":"Goldstein","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"ref121","first-page":"270","article-title":"KT The role and regulation of secretion of erythropoietin in pregnancy Medycyna wieku rozwojowego","volume":"17","author":"Kowalska","year":"2013"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1034\/j.1600-0609.2003.00085.x","article-title":"Haemoglobin during pregnancy : relationship to erythropoietin and haematinic status","volume":"71","author":"McMullin","year":"2003","journal-title":"Eur J Haematol"},{"key":"ref01","first-page":"11","article-title":"Maternal plasma cell - free fetal and maternal DNA at weeks gestation : relation to fetal and maternal characteristics and pregnancy outcomes","volume":"23","author":"Poon","year":"2013","journal-title":"Fetal Diagn Ther"},{"key":"ref41","article-title":"Early administration of low - dose aspirin for the prevention of severe and mild preeclampsia : a systematic review and meta - analysis","volume":"31","author":"Roberge","year":"2014","journal-title":"Am J Perinatol"},{"key":"ref101","first-page":"545","article-title":"Serum immunoreactive erythropoietin during pregnancy and in the early postpartum","author":"Beguin","year":"1990"},{"key":"ref111","first-page":"7","article-title":"Fetal and maternal erythropoietin levels in normal pregnancy","volume":"21","author":"Ireland","year":"1992","journal-title":"Fetal Diagn Ther"},{"key":"ref361","first-page":"23","article-title":"Lack of permeability of the human placenta for erythropoietin","author":"Schneider","year":"1995","journal-title":"J Perinat Med"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2015-0079\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T21:32:20Z","timestamp":1619040740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2015-0079\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":36,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1515\/jpm-2015-0079","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}