{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:52:42Z","timestamp":1773096762171,"version":"3.50.1"},"reference-count":60,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate if early pregnancy serum neopterin concentrations (EPSN) could predict spontaneous preterm birth (SPB).<\/jats:p><jats:p>EPSN was measured in 92 sera collected from 46 pregnant women with birth at term and 40 sera from 20 pregnant women with preterm birth. Two sera were collected for each case: in the first and early second trimester.<\/jats:p><jats:p>EPSN concentrations correlate with gestational age (\u03c1=0.275, P=0.001), a correlation which was present in both groups: term and preterm birth. EPSN were higher in pregnancies with SPB compared with normal pregnancies (6.27\u00b11.03 vs. 6.04\u00b10.15, P=0.039). Patients with SPB showed a considerable increase of EPSN in the second trimester compared with patients with birth at term (7.30\u00b11.53 vs. 6.16\u00b10.23, P=0.043). A sharper increase was found in the group with SPB before 32 weeks of pregnancy (wp) (9.83\u00b14.36 vs. 6.16\u00b10.23, P=0.016). Pregnant women with an early second trimester serum neopterin value of above 8 nmol\/L are associated with a risk of SPB before 32 wp (odds ratio=14.4, P=0.01) and of SPB before 34 wp (odds ratio=3.6, P=0.05), respectively.<\/jats:p><jats:p>EPSN increases with the gestational age and predicts SPB in asymptomatic pregnant women.<\/jats:p>","DOI":"10.1515\/jpm-2015-0081","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T10:02:38Z","timestamp":1467280958000},"source":"Crossref","is-referenced-by-count":13,"title":["Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women"],"prefix":"10.1515","volume":"44","author":[{"given":"Dan Bogdan","family":"Navolan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Vladareanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imad","family":"Lahdou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Ciohat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kleist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorin","family":"Grigoras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu","family":"Vladareanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Terness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioan","family":"Sas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref291","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/aji.12141","article-title":"Detection 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Maternal factors associated with three phenotypes: spontaneous preterm labour, preterm pre-labour rupture of membranes and medically indicated preterm birth","volume":"25","year":"2012","journal-title":"J Matern Fetal Neonatal Med."},{"key":"ref581","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.fertnstert.2013.02.013","article-title":"Fertility rate and subsequent pregnancy outcomes after conservative surgical techniques in postpartum hemorrhage: 15 years of literature","volume":"99","year":"2013","journal-title":"Fertil Steril."},{"key":"ref351","first-page":"164081","article-title":"Biochemical markers of spontaneous preterm birth","volume":"2014","year":"2014","journal-title":"Biomed Res Int."},{"key":"ref451","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/13506120500223241","article-title":"Evaluation of amniotic fluid cytokines in preterm labor and intact membranes","volume":"18","year":"2005","journal-title":"J Matern Fetal Neonatal 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infection\/inflammation, and spontaneous parturition at term: a role for interleukin-10","volume":"21","year":"2008","journal-title":"J Matern Fetal Neonatal Med."},{"key":"ref491","first-page":"1","article-title":"Increased neopterin level and chitotriosidase activity in pregnant women with threatened preterm labor","year":"2014","journal-title":"J Matern Fetal Neonatal Med."},{"key":"ref271","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.fertnstert.2013.02.013","article-title":"Fertility rate and subsequent pregnancy outcomes after conservative surgical techniques in postpartum hemorrhage: 15 years of literature","volume":"99","year":"2013","journal-title":"Fertil Steril."},{"key":"ref141","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/13506120500223241","article-title":"Evaluation of amniotic fluid cytokines in preterm labor and intact membranes","volume":"18","year":"2005","journal-title":"J Matern Fetal Neonatal Med."},{"key":"ref501","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0301-2115(97)00083-3","article-title":"Interleukin-6 and neopterin levels in serum of patients with preterm labour with and without infection","volume":"74","year":"1997","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1471-0528.2003.00021.x","article-title":"Classification and heterogeneity of preterm birth","volume":"110","year":"2003","journal-title":"BJOG."},{"key":"ref241","first-page":"170","article-title":"Neopterin concentrations in fetal and maternal blood: a marker of cell-mediated immune activation","year":"1999 181","journal-title":"Am J Obstet Gynecol."},{"key":"ref331","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1471-0528.2003.00021.x","article-title":"Classification and heterogeneity of preterm 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