{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:51:57Z","timestamp":1755600717822},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mid trimester fetal anatomy scan is a fundamental part of routine antenatal care. Some U\/S soft markers or controversial U\/S signs are seen during the scan and create some confusion regarding their relation to fetal chromosomal abnormalities. Example of these signs: echogenic focus in the heart, echogenic bowel, renal pyelectasis, ventriculomegaly, polydactely, club foot, choroid plexus cyst, single umbilical artery. We are presenting an evidence based approach from the literature for management of these controversial U\/S signs.<\/jats:p>","DOI":"10.1515\/jpm-2015-0223","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T22:47:35Z","timestamp":1445986055000},"source":"Crossref","is-referenced-by-count":11,"title":["Controversial ultrasound findings in mid trimester pregnancy. Evidence based approach"],"prefix":"10.1515","volume":"44","author":[{"given":"Alaa","family":"Ebrashy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asim","family":"Kurjak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah","family":"Adra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Labaran Dayyabu","family":"Aliyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuangsit","family":"Wataganara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Augusto Moreira","family":"de 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marker of chromosomal abnormality Ultrasound","volume":"17","author":"Huggon","year":"2001","journal-title":"Obstet Gynecol"},{"key":"ref631","first-page":"884","article-title":"Second trimester prenatal ultrasound for the detection of pregnancies at increased risk of down syndrome","volume":"27","author":"Smith","year":"2007"},{"key":"ref551","first-page":"327","article-title":"diagnosis and follow up of cases of unilateral ventriculomegaly Ultrasound","volume":"14","author":"Senat","year":"1999","journal-title":"Prenatal Obstet Gynecol"},{"key":"ref211","first-page":"212","article-title":"AT Counseling in isolated mild fetal ventriculomegaly Ultrasound","volume":"24","author":"Melchiorre","year":"2009","journal-title":"Obstet Gynecol"},{"key":"ref311","first-page":"680","article-title":"collaborative group fetal bowel and down syndrome : results of French collaborative study based on prospective 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scenario Ultrasound","volume":"16","author":"Sepulveda","year":"2000","journal-title":"Obstet Gynecol"},{"key":"ref661","first-page":"159","article-title":"Fetal echogenic bowel : parameters to be considered in differential diagnosis Ultrasound","volume":"16","author":"Strocker","year":"2000","journal-title":"Am Obstet Gynecol"},{"key":"ref261","first-page":"884","article-title":"Second trimester prenatal ultrasound for the detection of pregnancies at increased risk of down syndrome","volume":"27","author":"Smith","year":"2007"},{"key":"ref491","first-page":"137","article-title":"Time to reconsider our approach to echogenic intracardiac focus and choroid plexus cysts","author":"Bethune","year":"2008","journal-title":"J Obstet Gynaecol"},{"key":"ref501","first-page":"20","article-title":"Fused umbilical arteries prenatal sonographic diagnosis and clinical significance 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abnormality Ultrasound","volume":"17","author":"Huggon","year":"2001","journal-title":"Obstet Gynecol"},{"key":"ref531","first-page":"117","article-title":"AS Antenatal detection of single umbilical artery dose it matter","volume":"23","author":"Gomall","year":"2003"},{"key":"ref601","first-page":"197","article-title":"The association of aneuploidy and mild fetal pyelectasis in an unselected population : the results of a multicenter population Ultrasound","volume":"17","author":"Chudleigh","year":"2001","journal-title":"Obstet Gynecol"},{"key":"ref451","first-page":"16059","article-title":"plexus cysts association with trisomy prospective of patients","author":"Reinsch","year":"1997","journal-title":"review Am J Obstet Gynecol"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0029-7844(97)00251-2","article-title":"MS plexus cysts infant and early childhood developmental outcome","author":"Digioanni","year":"1997","journal-title":"Obstet 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