{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:07:38Z","timestamp":1787872058570,"version":"build-2784847793"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this meta-analysis is to assess the value of fetal cerebro-placental Doppler ratio (CPR) in predicting adverse perinatal outcome in pregnancies with fetal growth restriction (FGR).<\/jats:p><jats:p>Three databases were used: MEDLINE, EMBASE (with online Ovid interface) and SCOPUS and studies from inception to April 2015 were included. Studies that reported perinatal outcomes of fetuses at risk of FGR or sonographically diagnosed FGR that were evaluated with CPR were considered eligible. Perinatal outcomes include cesarean section (CS) for fetal distress, APGAR scores at 5 min, neonatal complications and admission to neonatal intensive care unit (NICU). Pooled data were expressed as odds ratio (OR) and confidence intervals (CI), and the summary receiver operating characteristic (SROC) curve was used to illustrate the diagnostic accuracy of CPR.<\/jats:p><jats:p>Seven studies were eligible (1428 fetuses). Fetuses with abnormal CPR were at higher risk of CS for fetal distress (OR=4.49, 95% CI [1.63, 12.42]), lower APGAR scores (OR=4.01, 95% CI [2.65, 6.08]), admission to NICU (OR=9.65, 95% CI [3.02, 30.85]), and neonatal complications (OR=11.00, 95% [3.64, 15.37]) than fetuses who had normal CPR. These risks were higher among studies that included fetuses diagnosed with FGR than fetuses at risk of FGR. Abnormal CPR had higher diagnostic accuracy for adverse perinatal outcomes among \u201csonographically diagnosed FGR\u201d studies than \u201cat risk of FGR\u201d studies.<\/jats:p><jats:p>Abnormal CPR is associated with substantial risk of adverse perinatal outcomes. The test seems to be particularly useful for follow up of fetuses with sonographically diagnosed FGR.<\/jats:p>","DOI":"10.1515\/jpm-2015-0274","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T09:44:26Z","timestamp":1452591866000},"source":"Crossref","is-referenced-by-count":21,"title":["Fetal cerebro-placental ratio and adverse perinatal outcome: systematic review and meta-analysis of the association and diagnostic performance"],"prefix":"10.1515","volume":"44","author":[{"given":"Ahmed Abobakr","family":"Nassr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Abdelmagied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif A.M.","family":"Shazly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref21","first-page":"49","article-title":"DJ Adult consequences of fetal growth restriction","author":"Barker","year":"2006","journal-title":"Clin Obstet Gynecol"},{"key":"ref141","doi-asserted-by":"crossref","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta - 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date pregnancies","author":"Devine","year":"1994","journal-title":"Obstet Gynecol"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00006250-199203000-00018","article-title":"Cerebral - umbilical Doppler ratio as a predictor of adverse perinatal outcome","volume":"20","author":"Gramellini","year":"1992","journal-title":"Obstet Gynecol"},{"key":"ref381","doi-asserted-by":"crossref","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta - analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"ref41","first-page":"134","article-title":"College of Obstetricians and Gynecologists Practice bulletin no fetal growth restriction","author":"ACOG","year":"2013","journal-title":"American Obstet Gynecol"},{"key":"ref121","article-title":"The Newcastle - Ottawa Scale for assessing the quality of nonrandomized studies in meta analyses Department of Community University of Ottawa www ohri ca programs clinical epidemiology oxford htm","author":"Wells","year":"2011","journal-title":"Epidemiology Medicine"},{"key":"ref291","first-page":"165","article-title":"Systematic and meta - analysis of middle cerebral artery Doppler to predict perinatal wellbeing","author":"Morris","year":"2012","journal-title":"review Eur Obstet Gynecol Reprod Biol"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0378-3782(96)01777-X","article-title":"Middle cerebral artery velocimetry as a predictor of hypoxemia in fetuses with increased resistance to blood flow in the umbilical artery","author":"Dubiel","year":"1997","journal-title":"Early Hum Dev"},{"key":"ref391","first-page":"53","article-title":"Manager program Version The Centre The Collaboration","author":"RevMan","year":"2014","journal-title":"Review Computer"},{"key":"ref421","first-page":"4","article-title":"The value of the middle cerebral to umbilical artery Doppler ratio in the prediction of neonatal outcome in patient with preeclampsia and gestational hypertension","author":"Shahinaj","year":"2010","journal-title":"Med"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0301-5629(95)00025-M","article-title":"Assessment of the fetal PO changes by cerebral and umbilical Doppler on lamb fetuses during acute hypoxia","volume":"21","author":"Arbeille","year":"1995","journal-title":"Ultrasound Med Biol"},{"key":"ref451","first-page":"37","article-title":"Fetal umbilical artery Doppler to predict compromise of fetal \/ neonatal wellbeing in a high - risk population systematic review and bivariate meta - analysis","author":"Morris","year":"2011","journal-title":"Ultrasound Obst Gyn"},{"key":"ref91","first-page":"71","article-title":"Middle cerebral artery to umbilical artery resistance index ratio in the prediction of neonatal outcome","volume":"25","author":"Makhseed","year":"2000","journal-title":"Int J Gynecol Obstet"},{"key":"ref201","first-page":"171","article-title":"Fetus - placenta - newborn : accuracy of the middle - cerebral - to - umbilical - artery resistance index ratio in the prediction of neonatal outcome in patients at high risk for fetal and neonatal complications","author":"Arias","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"ref361","article-title":"The Newcastle - Ottawa Scale for assessing the quality of nonrandomized studies in meta analyses Department of Community University of Ottawa www ohri ca programs clinical epidemiology oxford htm","author":"Wells","year":"2011","journal-title":"Epidemiology Medicine"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0301-5629(95)00025-M","article-title":"Assessment of the fetal PO changes by cerebral and umbilical Doppler on lamb fetuses during acute hypoxia","volume":"21","author":"Arbeille","year":"1995","journal-title":"Ultrasound Med Biol"},{"key":"ref331","first-page":"71","article-title":"Middle cerebral artery to umbilical artery resistance index ratio in the prediction of neonatal outcome","volume":"25","author":"Makhseed","year":"2000","journal-title":"Int J Gynecol Obstet"},{"key":"ref411","first-page":"322","article-title":"Association between an abnormal cerebroplacental ratio and the development of severe pre - 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