{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:58:56Z","timestamp":1774526336998,"version":"3.50.1"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to determine effective predictive factors for primary postpartum hemorrhage (PPH) among clinical blood parameters associated with coagulation and fibrinolysis and demographic characteristics.<\/jats:p><jats:p>We retrospectively studied 1032 women who underwent determinations of clinical blood parameters at gestational week (GW) 29\u201332 and GW 35\u201337 and gave birth to singleton infants at our hospital between January 2011 and December 2013. PPH was defined as estimated blood loss \u2265700 mL. Multivariate logistic regression analyses were used to determine independent risk factors and odds ratios (OR) for PPH.<\/jats:p><jats:p>PPH occurred in 104 of 1032 women (10%). Three blood variables, fibrinogen level &lt;4.0 g\/L (OR [95% CI], 1.96 [1.18\u20133.27]), antithrombin activity &lt;85% of normal activity level (1.84 [1.05\u20133.21]), and D-dimer level &gt;2.7 \u03bcg\/mL (2.03 [1.29\u20133.19]) at GW 35\u201337, and three demographic characteristics, maternal age \u226535 years (1.75 [1.15\u20132.68]), BMI &gt;28.2 kg\/m<\/jats:p><jats:p>Among blood parameters, higher D-dimer levels and lower levels of antithrombin activity and fibrinogen in late gestation were independent risk factors for PPH.<\/jats:p>","DOI":"10.1515\/jpm-2015-0287","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T09:44:26Z","timestamp":1452591866000},"source":"Crossref","is-referenced-by-count":14,"title":["Higher D-dimer level in the early third trimester predicts the occurrence of postpartum hemorrhage"],"prefix":"10.1515","volume":"44","author":[{"given":"Naho","family":"Endo-Kawamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mana","family":"Obata-Yasuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rena","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Mayumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref01","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","article-title":"WHO analysis of causes of maternal death: a systematic review","volume":"367","year":"2006","journal-title":"Lancet."},{"key":"ref61","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1471-2393-9-55","article-title":"Trends in postpartum hemorrhage in high resource countries: a review and recommendations from the International Postpartum Hemorrhage Collaborative Group","volume":"9","year":"2009","journal-title":"BMC Pregnancy Childbirth."},{"key":"ref131","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/ajo.12047","article-title":"The effects of an increasing gradient of maternal obesity on pregnancy outcomes","volume":"53","year":"2013","journal-title":"Aust N Z J Obstet Gynaecol."},{"key":"ref211","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1034\/j.1600-0412.2002.810907.x","article-title":"Antithrombin III activity and platelet count are more likely to decrease in twin pregnancies than in singleton pregnancies","volume":"81","year":"2002","journal-title":"Acta Obstet Gynecol Scand."},{"key":"ref401","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.thromres.2014.11.030","article-title":"Fibrinogen levels in the late stage of twin pregnancy","volume":"135","year":"2015","journal-title":"Thromb Res."},{"key":"ref341","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1093\/humrep\/15.11.2433","article-title":"The risks associated with pregnancy in women aged 35 years or older","volume":"15","year":"2000","journal-title":"Hum Reprod."},{"key":"ref421","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ijoa.2014.06.004","article-title":"Antenatal fibrinogen concentrations and postpartum haemorrhage","volume":"23","year":"2014","journal-title":"Int J Obstet Anesth."},{"key":"ref411","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/bja\/78.6.678","article-title":"Pre-anaesthetic assessment of coagulation abnormalities in obstetric patients; 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