{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:59:26Z","timestamp":1778954366886,"version":"3.51.4"},"reference-count":62,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To examine potential correlations between maternal serum placental protein-13 (PP-13) and first trimester maternal and placental factors, and to evaluate the association of this marker with adverse pregnancy outcome.<\/jats:p><jats:p>Serum samples from prospectively enrolled patients between 11 and 13 weeks and 6 days were analyzed for PP-13 using an ELISA assay. The relationships between maternal serum PP-13 levels and gestational age, maternal age, ethnicity, parity, smoking status, body mass index (BMI), mean arterial blood pressure, uterine and umbilical artery Doppler parameters were examined. The association between first-trimester PP-13 levels and subsequent pre-eclampsia and delivery of a small for gestational age (SGA) neonate was also investigated, after excluding patients who received aspirin.<\/jats:p><jats:p>In 908 patients, PP-13 levels ranged from 8.0 to 537.5 pg\/mL. A significant negative correlation was identified between PP13 and BMI (Spearman rho \u20130.20, P&lt;0.0001). Smoking significantly decreased PP-13 (P&lt;0.01). No relationship was identified with the other parameters. In a subgroup of 668 low-risk patients who did not receive aspirin, PP-13 levels were not associated with development of pre-eclampsia, SGA or the combination of them.<\/jats:p><jats:p>First-trimester PP-13 levels are significantly correlated with BMI and smoking. These correlations appear independent of uterine and umbilical artery resistance. In low risk patients, PP-13 levels fail to predict the risk for pre-eclampsia or SGA.<\/jats:p>","DOI":"10.1515\/jpm-2015-0324","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T20:59:02Z","timestamp":1456347542000},"source":"Crossref","is-referenced-by-count":11,"title":["Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome"],"prefix":"10.1515","volume":"44","author":[{"given":"Viola","family":"Seravalli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael Inna","family":"Grimpel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamutal","family":"Meiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Blitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet A.","family":"Baschat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref521","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1469-0705.1999.14030159.x","article-title":"The publishing of papers on first-trimester Doppler","volume":"14","year":"1999","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref551","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/pd.2375","article-title":"Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia","volume":"29","year":"2009","journal-title":"Prenat Diagn."},{"key":"ref91","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/uog.2686","article-title":"A novel approach to first-trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasound","volume":"27","year":"2006","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref111","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/uog.3876","article-title":"First-trimester maternal serum PP-13, PAPP-A and second-trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia","volume":"29","year":"2007","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref141","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000321694","article-title":"Prediction of small-for-gestation neonates from biophysical and biochemical markers at 11-13 weeks","volume":"29","year":"2011","journal-title":"Fetal Diagn 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predictors of small-for-gestational-age infants","volume":"211","year":"2014","journal-title":"Am J Obstet Gynecol."},{"key":"ref171","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/pd.1921","article-title":"First-trimester maternal placental protein 13 levels in pregnancies resulting in adverse outcomes","volume":"28","year":"2008","journal-title":"Prenat Diagn."},{"key":"ref71","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.placenta.2003.12.009","article-title":"Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies","volume":"25","year":"2004","journal-title":"Placenta."},{"key":"ref271","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/uog.7559","article-title":"First-trimester markers for the prediction of pre-eclampsia in women with a-priori high risk","volume":"35","year":"2010","journal-title":"Ultrasound Obstet 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restriction","volume":"197","year":"2007","journal-title":"Am J Obstet Gynecol."},{"key":"ref381","first-page":"348","article-title":"Placental protein 13 (PP13) \u2013 a placental immunoregulatory galectin protecting pregnancy","volume":"5","year":"2014","journal-title":"Front Immunol."},{"key":"ref501","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1515\/cclm-2012-0566","article-title":"ADAM12s and PP13 as first trimester screening markers for adverse pregnancy outcome","volume":"51","year":"2013","journal-title":"Clin Chem Lab Med."},{"key":"ref201","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1469-0705.1999.14030159.x","article-title":"The publishing of papers on first-trimester Doppler","volume":"14","year":"1999","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref251","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejogrb.2011.12.031","article-title":"Combination of uterine artery Doppler velocimetry and maternal serum placental growth factor estimation in predicting occurrence of pre-eclampsia in early second trimester pregnancy: a prospective cohort study","volume":"161","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"ref401","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/1933719111424445","article-title":"Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia","volume":"19","year":"2012","journal-title":"Reprod Sci."},{"key":"ref81","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/1933719111424445","article-title":"Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia","volume":"19","year":"2012","journal-title":"Reprod Sci."},{"key":"ref601","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.placenta.2012.05.012","article-title":"First trimester screening of maternal placental protein 13 for predicting preeclampsia and small for gestational age: in-house study and systematic review","volume":"33","year":"2012","journal-title":"Placenta."},{"key":"ref621","doi-asserted-by":"crossref","first-page":"383.e1","DOI":"10.1016\/j.ajog.2010.06.014","article-title":"Screening for preeclampsia using first-trimester serum markers and uterine artery Doppler in nulliparous women","volume":"203","year":"2010","journal-title":"Am J Obstet Gynecol."},{"key":"ref351","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/pd.4397","article-title":"First-trimester maternal factors and biomarker screening for preeclampsia","volume":"34","year":"2014","journal-title":"Prenat Diagn."},{"key":"ref571","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejogrb.2011.12.031","article-title":"Combination of uterine artery Doppler velocimetry and maternal serum placental growth factor estimation in predicting occurrence of pre-eclampsia in early second trimester pregnancy: a prospective cohort study","volume":"161","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"ref431","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/uog.3876","article-title":"First-trimester maternal serum PP-13, PAPP-A and second-trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia","volume":"29","year":"2007","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref361","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000341264","article-title":"Competing risks model in early screening for preeclampsia by biophysical and biochemical markers","volume":"33","year":"2013","journal-title":"Fetal Diagn Ther."},{"key":"ref611","first-page":"391","article-title":"Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia","volume":"19","year":"2013","journal-title":"Hum Reprod."},{"key":"ref231","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/pd.2375","article-title":"Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia","volume":"29","year":"2009","journal-title":"Prenat Diagn."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1161\/HYPERTENSIONAHA.107.104646","article-title":"Mean arterial pressure at 11(+0) to 13(+6) weeks in the prediction of preeclampsia","volume":"51","year":"2008","journal-title":"Hypertension."},{"key":"ref151","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/10641955.2010.484081","article-title":"Placental protein-13 and pregnancy-associated plasma protein-A as first trimester screening markers for hypertensive disorders and small for gestational age outcomes","volume":"30","year":"2011","journal-title":"Hypertens Pregnancy."}],"container-title":["Journal of Perinatal 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