{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:17:35Z","timestamp":1780323455545,"version":"3.54.1"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2015-0333_s_999_w2aab2b8c24b1b7b1aab1c15b1Aa\">\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p> Though the outcome for children with congenital diaphragmal hernia (CDH) is improving, management of seriously compromised respiratory and cardiovascular function remains a great challenge. The aim of this study was to review a tertiary center experience in treating children with CDH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2015-0333_s_998_w2aab2b8c24b1b7b1aab1c15b2Aa\">\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p> Retrospective observational study from January 2005 to December 2014.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2015-0333_s_997_w2aab2b8c24b1b7b1aab1c15b3Aa\">\n                  <jats:title>Setting:<\/jats:title>\n                  <jats:p> Neonatal Intensive Care Unit (NICU) of University Children Hospital (UCH), Belgrade, Serbia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2015-0333_s_996_w2aab2b8c24b1b7b1aab1c15b4Aa\">\n                  <jats:title>Patients:<\/jats:title>\n                  <jats:p> Children with CDH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2015-0333_s_995_w2aab2b8c24b1b7b1aab1c15b5Aa\">\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p> The CDH was diagnosed prenatally in 23% patients. An overall survival rate was 62%. Among those patients who underwent surgical repair 29 (90%) survived. There was statistically significant difference in survival rate between operated patients and total examined population (P=0.020). Prenatally diagnosed neonates with CDH had significantly lower survival rate comparing to those who were postnatally diagnosed (20% vs. 75%; P=0.002). Fatal outcome was more frequent in patients with small birth weight comparing to those with normal birth weight (67% vs. 30%; P=0.046).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2015-0333_s_994_w2aab2b8c24b1b7b1aab1c15b6Aa\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p> Our center survival rate for CDH is in accordance with other reported studies. Based on our experience there are potential points for further improvement. First, further increase of prenatal detection, planning for delivery, and coordinated transfer to tertiary institution, in order to avoid transfer of near death patients. Second, preoperative management in the NICU. This could be done by more uniform implementation of current consensual guidelines in monitoring, mechanical ventilation and circulatory support of these delicate patients, together with rationale use of newer therapeutic resources.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2015-0333","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T08:48:05Z","timestamp":1458204485000},"page":"913-918","source":"Crossref","is-referenced-by-count":10,"title":["Congenital diaphragmatic hernia \u2013 a Belgrade single center experience"],"prefix":"10.1515","volume":"44","author":[{"given":"Jasna","family":"Kalanj","sequence":"first","affiliation":[{"name":"Pediatric and Neonatal Intensive Care Unit, University Children Hospital, Tir\u0161ova 10, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-5591","authenticated-orcid":false,"given":"Petar","family":"Salevic","sequence":"additional","affiliation":[{"name":"Pediatric and Neonatal Intensive Care Unit, University Children Hospital, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snezana","family":"Rsovac","sequence":"additional","affiliation":[{"name":"Pediatric and Neonatal Intensive Care Unit, University Children Hospital, Tir\u0161ova 10, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Medjo","sequence":"additional","affiliation":[{"name":"Pediatric and Neonatal Intensive Care Unit, University Children Hospital, Belgrade, Serbia"},{"name":"Department of Pediatrics, Medical Faculty, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja Sindjic","family":"Antunovic","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Medical Faculty, University of Belgrade, Belgrade, Serbia"},{"name":"Department of Neonatal Surgery, University Children Hospital, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dusica","family":"Simic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical Faculty, University of Belgrade, Belgrade, Serbia"},{"name":"Department of Anesthesiology, University Children Hospital, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"2023033121172597457_j_jpm-2015-0333_ref_001_w2aab2b8c24b1b7b1ab2b1b1Aa","unstructured":"Mielniczuk M, Kusza K, Brzezi\u0144ski P, Jakubczyk M, Mielniczuk K, Czerwionka-Szaflarska M. Current guidelines on management of congenital diaphragmatic hernia. Anaesthesiol Intensive Ther. 2012;44:232\u20137."},{"key":"2023033121172597457_j_jpm-2015-0333_ref_002_w2aab2b8c24b1b7b1ab2b1b2Aa","unstructured":"Wright J, Forster C, Sharkey D. Management of congenital diaphragmatic hernia. Nottingham Neonatal Service-Clinical Guidelines. Nottingham, UK. 2013. Available at: https:\/\/www.google.rs\/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwi7g-_izsjKAhWBWiwKHV8aBwwQFggfMAA&url=http%3A%2F%2Fwww.nuh.nhs.uk%2Fhandlers%2Fdownloads.ashx%3Fid%3D61198&usg=AFQjCNHXOXyjRe5pikSQxwydP2V1EsutmQ&bvm=bv.112766941,d.bGg."},{"key":"2023033121172597457_j_jpm-2015-0333_ref_003_w2aab2b8c24b1b7b1ab2b1b3Aa","unstructured":"Pober RB, Russell KM, Guernsey Ackerman K. Congenital Diaphragmatic Hernia Overview. GeneReviews\u00ae [Internet]. Initial Posting: February 1, 2006; Last Update: March 16, 2010. Available online at: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1359\/."},{"key":"2023033121172597457_j_jpm-2015-0333_ref_004_w2aab2b8c24b1b7b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Pober BR. Genetic aspects of human congenital diaphragmatic hernia. Clin Genet. 2008;74:1\u201315.","DOI":"10.1111\/j.1399-0004.2008.01031.x"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_005_w2aab2b8c24b1b7b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Tovar JA. Congenital diaphragmatic hernia. Orphanet J Rare Dis. 2012;7:1.","DOI":"10.1186\/1750-1172-7-1"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_006_w2aab2b8c24b1b7b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Armstrong K, Franklin O, Molloy EJ. Congenital diaphragmatic hernia and congenital heart disease. In: Molloy EJ, editor. Congenital diaphragmatic hernia-prenatal to childhood management and outcomes. Rijeka, Croatia: InTech; 2012. p. 113\u201324. Available at: http:\/\/www.intechopen.com\/books\/congenital-diaphragmatic-hernia-prenatal-to-childhood-management-and-outcomes\/congenital-diaphragmatic-hernia-and-congenital-heart-disease.","DOI":"10.5772\/31825"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_007_w2aab2b8c24b1b7b1ab2b1b7Aa","unstructured":"Congenital diaphragmatic hernia. In NCCU Clinical Guidelines \u2013 Section 2: Respiratory problems and management. King Edward Memorial\/Princess Margaret Hospitals, Perth Western Australia. Date created June 2006. Date last revised May 2015. Available at: http:\/\/www.kemh.health.wa.gov.au\/services\/nccu\/guidelines\/documents\/2\/CongenitalDiaphragmaticHernia%28CDH%29.pdf."},{"key":"2023033121172597457_j_jpm-2015-0333_ref_008_w2aab2b8c24b1b7b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Reiss I, Schaible T, van den Hout L, Capolupo I, Allegaert K, van Heijst A, et al. Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: the CDH EURO Consortium consensus. Neonatology 2010;98:354\u201364.","DOI":"10.1159\/000320622"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_009_w2aab2b8c24b1b7b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Wynn J, Krishnan U, Aspelund G, Zhang Y, Duong J, Stolar CJ, et al. Outcomes of Congenital Diaphragmatic Hernia in the modern era of management. J Pediatr. 2013;163:114\u20139.","DOI":"10.1016\/j.jpeds.2012.12.036"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_010_w2aab2b8c24b1b7b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Kotecha S, Barbato A, Bush A, Davenport M, Delacourt C, Deprest J, et al. Congenital diaphragmatic hernia: ERS task force report. Eur Respir J. 2012;39:820\u20139.","DOI":"10.1183\/09031936.00066511"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_011_w2aab2b8c24b1b7b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Tracy ET, Mears SE, Smith PB, Danko, Danko ME, Diesen DL, et al. Protocolized approach to the management of congenital diaphragmatic hernia: benefits of reducing variability in care. J Pediatr Surg. 2010;45:1343\u201348.","DOI":"10.1016\/j.jpedsurg.2010.02.104"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_012_w2aab2b8c24b1b7b1ab2b1c12Aa","unstructured":"Congenital Diaphragmatic Hernia: Management Guidelines. Duke Children\u2019s Hospital and Health Center. Durham, North Carolina. 2009. Available at: http:\/\/www.dukechildrens.org\/repository\/dukechildrens\/2009\/11\/03\/14\/08\/38\/7953\/CDH_management_guidelines.pdf."},{"key":"2023033121172597457_j_jpm-2015-0333_ref_013_w2aab2b8c24b1b7b1ab2b1c13Aa","unstructured":"Snider AR, Serwer GA, Ritter SB. Echocardiography in pediatric heart disease. 2nd ed. St Louis: Mosby-year book; 1997. p. 164\u201370."},{"key":"2023033121172597457_j_jpm-2015-0333_ref_014_w2aab2b8c24b1b7b1ab2b1c14Aa","doi-asserted-by":"crossref","unstructured":"Storme L, Aubry E, Rakza T, Houeijeh A, Debarge V, Tourneux P, et al. Patophysiology of persistent pulmonary hypertension of the newborn: Impact of the perinatal environment. Arch Cardiovasc Dis. 2013;106:169\u201377.","DOI":"10.1016\/j.acvd.2012.12.005"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_015_w2aab2b8c24b1b7b1ab2b1c15Aa","doi-asserted-by":"crossref","unstructured":"Gentili A, Giuntoli L, Bacchi RM, Masciopinto F, Lima M, Baroncini S. Neonatal congenital diaphragmatic hernia: respiratory and blood-gas derived indices in choosing surgical timing. Minerva Anestesiol. 2012;78:1117\u201325.","DOI":"10.1155\/2012\/402170"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_016_w2aab2b8c24b1b7b1ab2b1c16Aa","doi-asserted-by":"crossref","unstructured":"Colvin J, Bower C, Dickinson JE, Sokol J. Outcomes of congenital diaphragmatic hernia: a population-based study in Western Australia. Pediatrics. 2005;116:356\u201363.","DOI":"10.1542\/peds.2004-2845"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_017_w2aab2b8c24b1b7b1ab2b1c17Aa","doi-asserted-by":"crossref","unstructured":"Khemakhem R, Haggui B, Rahay H, Nouira F, Charieg A, Ghorbel S, et al. Congenital diaphragmatic hernia in neonate: a retrospective study about 28 observations. Afr J Paediatr Surg. 2012;9:217\u201322.","DOI":"10.4103\/0189-6725.104723"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_018_w2aab2b8c24b1b7b1ab2b1c18Aa","unstructured":"Cadichon SB. Congenital diaphragmatic hernia. In: Praveen K, Burton BK, editors. Congenital malformations: evidence-based evaluation and management. New York, NY: McGraw-Hill Medical; 2008. p. 151\u20139."},{"key":"2023033121172597457_j_jpm-2015-0333_ref_019_w2aab2b8c24b1b7b1ab2b1c19Aa","doi-asserted-by":"crossref","unstructured":"Lee SYS, Tan KH. Antenatally diagnosed congenital diaphragmatic hernia in Singapore: a five-year series. Singapore Med J. 2013;54:432\u20136.","DOI":"10.11622\/smedj.2013149"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_020_w2aab2b8c24b1b7b1ab2b1c20Aa","doi-asserted-by":"crossref","unstructured":"Werlein A, Goebert P, Maier RF. Planning delivery in cases of congenital malformations from the neonatologist\u2019s point of view. Z Geburstshilfe Neonatol. 2014;218:27\u201333.","DOI":"10.1055\/s-0034-1367052"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_021_w2aab2b8c24b1b7b1ab2b1c21Aa","doi-asserted-by":"crossref","unstructured":"Bialkowski A, Moenkemeyer F, Patel N. Intravenous sildenafil in the Management of Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia. Eur J Pediatr Surg. 2015;25:171\u20136.","DOI":"10.1055\/s-0033-1357757"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_022_w2aab2b8c24b1b7b1ab2b1c22Aa","doi-asserted-by":"crossref","unstructured":"Yamamoto Y, Thebaud B, Vadivel A, Eaton F, Jain V, Hornberger LK. Doppler parameters of fetal lung hypoplasia and impact of Sildenafil. Am J Obstet gynecol. 2014;211:263.e1\u20138.","DOI":"10.1016\/j.ajog.2014.03.013"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_023_w2aab2b8c24b1b7b1ab2b1c23Aa","unstructured":"Rocha G, Baptista MJ, Correia-Pinto J, Guimaraes H. Congenital diaphragmatic hernia: experience of 14 years. Minerva Pediatr. 2013;65:271\u20138."},{"key":"2023033121172597457_j_jpm-2015-0333_ref_024_w2aab2b8c24b1b7b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Brindle ME, Cook EF, Tibboel D, Lally PA, Lally KP, Congenital diaphragmatic hernia study group. A clinical prediction rule for the severity of congenital diaphragmatic hernias in newborn. Pediatrics. 2014;134:e413\u20139.","DOI":"10.1542\/peds.2013-3367"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_025_w2aab2b8c24b1b7b1ab2b1c25Aa","doi-asserted-by":"crossref","unstructured":"Edmonds L, Boniface C, Alcock G, Stalewski H, Shi E. Congenital diaphragmatic hernia in Northern Queensland. J Paediatr Child Health. 2013;49:475\u20139.","DOI":"10.1111\/jpc.12211"},{"key":"2023033121172597457_j_jpm-2015-0333_ref_026_w2aab2b8c24b1b7b1ab2b1c26Aa","doi-asserted-by":"crossref","unstructured":"O\u2019Mahony E, Stewart M, Sampson A, East C, Palma-Dias R. Perinatal outcome of congenital diaphragmatic hernia in an Australian tertiary hospital. Aust N J Z Obstet Gynaecol. 2012;52:189\u201394.","DOI":"10.1111\/j.1479-828X.2011.01381.x"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpme.2016.44.issue-8\/jpm-2015-0333\/jpm-2015-0333.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2015-0333\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2015-0333\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T10:57:10Z","timestamp":1680346630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2015-0333\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":26,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,4,18]]},"published-print":{"date-parts":[[2016,11,1]]}},"alternative-id":["10.1515\/jpm-2015-0333"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2015-0333","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}