{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T11:59:06Z","timestamp":1648814346122},"reference-count":78,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>To compare endotracheal fluid (EF) and amniotic fluid (AF) phospholipidic profile changes following tracheal occlusion (TO) in the congenital diaphragmatic hernia (CDH) fetal lamb model, in order to support the efficacy of TO on lung maturity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A diaphragmatic defect was induced at 70 days\u2019 gestation, TO was carried out at day 102 and cesarean section at 136 days\u2019 gestation. EF and AF samples, collected at delivery, were evaluated using mass spectrometry (the analysis focused on palmitoyloleoyl-phosphatidylcholine [POPC, PC(18:1\/16:0)], dipalmitoyl-phosphatidylcholine [DPPC, PC(16:0\/16:0)] and sphingomyelins [SMs]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The effects of CDH and TO were different on AF and EF. POPC levels were higher than DPPC levels in AF of healthy lambs. Following induction of the diaphragmatic malformation, an evident decrease in POPC was noted, while a substantial return to normal POPC levels and an increased DPPC peak were prompted by the TO. After CDH induction, a decrease in N-palmitoyl-D-sphingomyelin [SM(d18:1\/16:0)] was revealed (P&lt;0.01) and an increased peak in SMs in AF was prompted by the TO (P=0.05). While the most represented phosphatidylcholine (PC) species in EF of healthy lambs was DPPC, CDH induced a decrease in the DPPC peak and treatment with TO induced its partial recovery. SMs were detectable only in healthy EF samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The phospholipid recovery profile following TO suggests the potential role of this therapy in restoring processes involved in surfactant-mediated lung maturation, even though other interactions involved in AF turnover should be considered. Moreover, these metabolites could be used as biomarkers of fetal pulmonary development.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2015-0334","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T07:50:00Z","timestamp":1470901800000},"source":"Crossref","is-referenced-by-count":0,"title":["Congenital diaphragmatic hernia: endotracheal fluid phospholipidic profile following tracheal occlusion in an experimental model"],"prefix":"10.1515","volume":"45","author":[{"given":"Gloria","family":"Pelizzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Mimmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Peiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Marotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Amoroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Fusillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Carlini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Calcaterra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref51","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/jpc.12508","article-title":"Congenital diaphragmatic hernia","volume":"50","year":"2014","journal-title":"J Paediatr Child Health."},{"key":"ref21","first-page":"51","article-title":"Mechanical forces in fetal lung development: opportunities for translational research","volume":"1","year":"2013","journal-title":"Front Pediatr."},{"key":"ref451","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1053\/j.sempedsurg.2014.09.008","article-title":"Congenital diaphragmatic hernia: where and what is the evidence?","volume":"23","year":"2014","journal-title":"Semin Pediatr Surg."},{"key":"ref361","first-page":"L381","article-title":"Hormonal regulation and cellular localization of fatty acid synthase in human fetal lung","volume":"277","year":"1999","journal-title":"Am J Physiol."},{"key":"ref421","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1053\/j.semperi.2013.11.005","article-title":"Congenital diaphragmatic hernia: treatment and outcomes","volume":"38","year":"2014","journal-title":"Semin Perinatol."},{"key":"ref181","doi-asserted-by":"crossref","first-page":"76. e1","DOI":"10.1016\/j.ajog.2010.01.046","article-title":"Calculation of gestational age in late second and third trimesters by ex vivo magnetic resonance spectroscopy of amniotic fluid","volume":"203","year":"2010","journal-title":"Am J Obstet Gynecol."},{"key":"ref591","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/jmri.21592","article-title":"(1)H HR-MAS spectroscopy for quantitative measurement of choline concentration in amniotic fluid as a marker of fetal lung maturity: inter- and intraobserver reproducibility study","volume":"28","year":"2008","journal-title":"J Magn Reson Imaging."},{"key":"ref371","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1289\/ehp.8455205","article-title":"Lung surfactant","volume":"55","year":"1984","journal-title":"Environ Health Perspect."},{"key":"ref211","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1021\/pr501120x","article-title":"Phospholipid profile of amniotic fluid in ovine model of congenital diaphragmatic hernia (CDH): the effect of fetal tracheal occlusion","volume":"14","year":"2015","journal-title":"J Proteome Res."},{"key":"ref581","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10334-009-0184-0","article-title":"Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy","volume":"22","year":"2009","journal-title":"MAGMA."},{"key":"ref241","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-4939-1031-1_5","article-title":"Regulation of amniotic fluid volume: evolving concepts","volume":"814","year":"2014","journal-title":"Adv Exp Med Biol."},{"key":"ref291","first-page":"5","article-title":"Pulmonary surfactants and their role in pathophysiology of lung disorders","volume":"51","year":"2013","journal-title":"Indian J Exp Biol."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1053\/j.semperi.2013.11.005","article-title":"Congenital diaphragmatic hernia: treatment and outcomes","volume":"38","year":"2014","journal-title":"Semin Perinatol."},{"key":"ref611","first-page":"1","article-title":"Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants","volume":"4","year":"2014","journal-title":"J Matern Fetal Neonatal Med."},{"key":"ref271","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0022-3468(97)90208-6","article-title":"Fetal lung growth after tracheal ligation is not solely a pressure phenomenon","volume":"32","year":"1997","journal-title":"J Pediatr Surg."},{"key":"ref401","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1152\/jappl.2001.91.2.589","article-title":"Mechanical stretch promotes alveolar epithelial type II cell differentiation","volume":"91","year":"2001","journal-title":"J Appl Physiol."},{"key":"ref151","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1053\/j.sempedsurg.2013.10.005","article-title":"Neonatal pulmonary physiology","volume":"22","year":"2013","journal-title":"Semin Pediatr Surg."},{"key":"ref721","first-page":"748","article-title":"The missing link in amniotic fluid volume regulation: intramembranous absorption","volume":"74","year":"1989","journal-title":"Obstet Gynecol."},{"key":"ref621","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/2049-6958-9-54","article-title":"Metabolomic profile of amniotic fluid to evaluate lung maturity: the diaphragmatic hernia lamb model","volume":"9","year":"2014","journal-title":"Multidiscip Respir Med."},{"key":"ref711","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0143-4004(95)90077-2","article-title":"Progress toward understanding the regulation of amniotic fluid volume: water and solute fluxes in and through the fetal membranes","volume":"16","year":"1995","journal-title":"Placenta."},{"key":"ref491","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/uog.12414","article-title":"Early fetoscopic tracheal occlusion for extremely severe pulmonary hypoplasia in isolated congenital diaphragmatic hernia: preliminary results","volume":"42","year":"2013","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref301","first-page":"153","article-title":"Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films","volume":"185C","year":"2015","journal-title":"Chem Phys Lipids."},{"key":"ref121","first-page":"36","article-title":"New Insights into Congenital Diaphragmatic Hernia \u2013 a Surgeon\u2019s introduction to CDH animal models","volume":"2","year":"2014","journal-title":"Front Pediatr."},{"key":"ref521","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.siny.2014.09.002","article-title":"Advances in the surgical approach to congenital diaphragmatic hernia","volume":"19","year":"2014","journal-title":"Semin Fetal Neonatal Med."},{"key":"ref201","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/jmri.21592","article-title":"(1)H HR-MAS spectroscopy for quantitative measurement of choline concentration in amniotic fluid as a marker of fetal lung maturity: inter- and intraobserver reproducibility study","volume":"28","year":"2008","journal-title":"J Magn Reson Imaging."},{"key":"ref601","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1021\/pr501120x","article-title":"Phospholipid profile of amniotic fluid in ovine model of congenital diaphragmatic hernia (CDH): the effect of fetal tracheal occlusion","volume":"14","year":"2015","journal-title":"J Proteome Res."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1152\/jappl.2001.91.2.589","article-title":"Mechanical stretch promotes alveolar epithelial type II cell differentiation","volume":"91","year":"2001","journal-title":"J Appl Physiol."},{"key":"ref71","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.earlhumdev.2014.09.013","article-title":"Congenital diaphragmatic hernia","volume":"90","year":"2014","journal-title":"Early Hum Dev."},{"key":"ref481","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1055\/s-0034-1382262","article-title":"Medical and regenerative solutions for congenital diaphragmatic hernia: a perinatal perspective","volume":"24","year":"2014","journal-title":"Eur J Pediatr Surg."},{"key":"ref501","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/uog.6450","article-title":"Severe diaphragmatic hernia treated by fetal endoscopic tracheal occlusion","volume":"34","year":"2009","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref231","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/2049-6958-9-54","article-title":"Metabolomic profile of amniotic fluid to evaluate lung maturity: the diaphragmatic hernia lamb model","volume":"9","year":"2014","journal-title":"Multidiscip Respir Med."},{"key":"ref561","first-page":"720514","article-title":"Metabolomics application in maternal-fetal medicine","volume":"2013","year":"2013","journal-title":"Biomed Res Int."},{"key":"ref691","first-page":"153","article-title":"Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films","volume":"185C","year":"2015","journal-title":"Chem Phys Lipids."},{"key":"ref261","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nprot.2013.004","article-title":"Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database","volume":"8","year":"2013","journal-title":"Nat Protoc."},{"key":"ref551","first-page":"L95","article-title":"Effects of mechanical factors on growth and maturation of the lung in fetal sheep","volume":"272","year":"1997","journal-title":"Am J Physiol."},{"key":"ref571","doi-asserted-by":"crossref","first-page":"76. e1","DOI":"10.1016\/j.ajog.2010.01.046","article-title":"Calculation of gestational age in late second and third trimesters by ex vivo magnetic resonance spectroscopy of amniotic fluid","volume":"203","year":"2010","journal-title":"Am J Obstet Gynecol."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/0009922812472249","article-title":"An evidence-based review of the current treatment of congenital diaphragmatic hernia","volume":"52","year":"2013","journal-title":"Clin Pediatr (Phila)."},{"key":"ref221","first-page":"1","article-title":"Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants","volume":"4","year":"2014","journal-title":"J Matern Fetal Neonatal Med."},{"key":"ref471","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0301-2115(00)00435-8","article-title":"Tracheal side effects of endoscopic balloon tracheal occlusion in the fetal lamb model","volume":"92","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"ref311","doi-asserted-by":"crossref","first-page":"R1426","DOI":"10.1152\/ajpregu.00496.2004","article-title":"Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals","volume":"289","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"ref281","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0925-4439(98)00060-X","article-title":"Pulmonary surfactant: functions and molecular composition","volume":"1408","year":"1998","journal-title":"Biochim Biophys Acta."},{"key":"ref191","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10334-009-0184-0","article-title":"Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy","volume":"22","year":"2009","journal-title":"MAGMA."},{"key":"ref351","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10334-011-0260-0","article-title":"Impact of prenatal stress on 1H NMR-based metabolic profiling of rat amniotic fluid","volume":"24","year":"2011","journal-title":"MAGMA."},{"key":"ref441","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/jpc.12508","article-title":"Congenital diaphragmatic hernia","volume":"50","year":"2014","journal-title":"J Paediatr Child Health."},{"key":"ref631","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-4939-1031-1_5","article-title":"Regulation of amniotic fluid volume: evolving concepts","volume":"814","year":"2014","journal-title":"Adv Exp Med Biol."},{"key":"ref01","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1152\/jappl.2000.89.5.2078","article-title":"Invited review: mechanochemical signal transduction in the fetal lung","volume":"89","year":"2000","journal-title":"J Appl Physiol."},{"key":"ref331","first-page":"748","article-title":"The missing link in amniotic fluid volume regulation: intramembranous absorption","volume":"74","year":"1989","journal-title":"Obstet Gynecol."},{"key":"ref111","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/uog.6450","article-title":"Severe diaphragmatic hernia treated by fetal endoscopic tracheal occlusion","volume":"34","year":"2009","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref341","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/0002-9378(92)91768-6","article-title":"Amniotic fluid composition changes during urine drainage and tracheoesophageal occlusion in fetal sheep","volume":"167","year":"1992","journal-title":"Am J Obstet Gynecol."},{"key":"ref391","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1152\/jappl.2000.89.5.2078","article-title":"Invited review: mechanochemical signal transduction in the fetal lung","volume":"89","year":"2000","journal-title":"J Appl Physiol."},{"key":"ref641","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nprot.2011.335","article-title":"Human Serum Metabolome (HUSERMET) Consortium: procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry","volume":"6","year":"2011","journal-title":"Nat Protoc."},{"key":"ref61","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1053\/j.sempedsurg.2014.09.008","article-title":"Congenital diaphragmatic hernia: where and what is the evidence?","volume":"23","year":"2014","journal-title":"Semin Pediatr Surg."},{"key":"ref651","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nprot.2013.004","article-title":"Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database","volume":"8","year":"2013","journal-title":"Nat Protoc."},{"key":"ref461","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.earlhumdev.2014.09.013","article-title":"Congenital diaphragmatic hernia","volume":"90","year":"2014","journal-title":"Early Hum Dev."},{"key":"ref541","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1053\/j.sempedsurg.2013.10.005","article-title":"Neonatal pulmonary physiology","volume":"22","year":"2013","journal-title":"Semin Pediatr Surg."},{"key":"ref131","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.siny.2014.09.002","article-title":"Advances in the surgical approach to congenital diaphragmatic hernia","volume":"19","year":"2014","journal-title":"Semin Fetal Neonatal Med."},{"key":"ref161","first-page":"L95","article-title":"Effects of mechanical factors on growth and maturation of the lung in fetal sheep","volume":"272","year":"1997","journal-title":"Am J Physiol."},{"key":"ref671","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0925-4439(98)00060-X","article-title":"Pulmonary surfactant: functions and molecular composition","volume":"1408","year":"1998","journal-title":"Biochim Biophys Acta."},{"key":"ref771","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jpedsurg.2014.08.005","article-title":"Congenital diaphragmatic hernia: focus on abnormal muscle formation","volume":"50","year":"2015","journal-title":"J Pediatr Surg."},{"key":"ref531","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1067\/msy.2000.107373","article-title":"Short-term tracheal occlusion corrects pulmonary vascular anomalies in the fetal lamb with diaphragmatic hernia","volume":"128","year":"2000","journal-title":"Surgery"},{"key":"ref751","first-page":"L381","article-title":"Hormonal regulation and cellular localization of fatty acid synthase in human fetal lung","volume":"277","year":"1999","journal-title":"Am J Physiol."},{"key":"ref731","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/0002-9378(92)91768-6","article-title":"Amniotic fluid composition changes during urine drainage and tracheoesophageal occlusion in fetal sheep","volume":"167","year":"1992","journal-title":"Am J Obstet Gynecol."},{"key":"ref741","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10334-011-0260-0","article-title":"Impact of prenatal stress on 1H NMR-based metabolic profiling of rat amniotic fluid","volume":"24","year":"2011","journal-title":"MAGMA."},{"key":"ref511","first-page":"36","article-title":"New Insights into Congenital Diaphragmatic Hernia \u2013 a Surgeon\u2019s introduction to CDH animal models","volume":"2","year":"2014","journal-title":"Front Pediatr."},{"key":"ref321","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0143-4004(95)90077-2","article-title":"Progress toward understanding the regulation of amniotic fluid volume: water and solute fluxes in and through the fetal membranes","volume":"16","year":"1995","journal-title":"Placenta."},{"key":"ref101","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/uog.12414","article-title":"Early fetoscopic tracheal occlusion for extremely severe pulmonary hypoplasia in isolated congenital diaphragmatic hernia: preliminary results","volume":"42","year":"2013","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref681","first-page":"5","article-title":"Pulmonary surfactants and their role in pathophysiology of lung disorders","volume":"51","year":"2013","journal-title":"Indian J Exp Biol."},{"key":"ref81","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0301-2115(00)00435-8","article-title":"Tracheal side effects of endoscopic balloon tracheal occlusion in the fetal lamb model","volume":"92","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"ref91","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1055\/s-0034-1382262","article-title":"Medical and regenerative solutions for congenital diaphragmatic hernia: a perinatal perspective","volume":"24","year":"2014","journal-title":"Eur J Pediatr Surg."},{"key":"ref251","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nprot.2011.335","article-title":"Human Serum Metabolome (HUSERMET) Consortium: procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry","volume":"6","year":"2011","journal-title":"Nat Protoc."},{"key":"ref411","first-page":"51","article-title":"Mechanical forces in fetal lung development: opportunities for translational research","volume":"1","year":"2013","journal-title":"Front Pediatr."},{"key":"ref431","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/0009922812472249","article-title":"An evidence-based review of the current treatment of congenital diaphragmatic hernia","volume":"52","year":"2013","journal-title":"Clin Pediatr (Phila)."},{"key":"ref761","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1289\/ehp.8455205","article-title":"Lung surfactant","volume":"55","year":"1984","journal-title":"Environ Health Perspect."},{"key":"ref661","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0022-3468(97)90208-6","article-title":"Fetal lung growth after tracheal ligation is not solely a pressure phenomenon","volume":"32","year":"1997","journal-title":"J Pediatr Surg."},{"key":"ref141","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1067\/msy.2000.107373","article-title":"Short-term tracheal occlusion corrects pulmonary vascular anomalies in the fetal lamb with diaphragmatic hernia","volume":"128","year":"2000","journal-title":"Surgery"},{"key":"ref701","doi-asserted-by":"crossref","first-page":"R1426","DOI":"10.1152\/ajpregu.00496.2004","article-title":"Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals","volume":"289","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"ref171","first-page":"720514","article-title":"Metabolomics application in maternal-fetal medicine","volume":"2013","year":"2013","journal-title":"Biomed Res Int."},{"key":"ref381","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jpedsurg.2014.08.005","article-title":"Congenital diaphragmatic hernia: focus on abnormal muscle formation","volume":"50","year":"2015","journal-title":"J Pediatr Surg."}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpme.2017.45.issue-2\/jpm-2015-0334\/jpm-2015-0334.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2015-0334\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:32:52Z","timestamp":1619055172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2015-0334\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":78,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1515\/jpm-2015-0334","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,1]]}}}