{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:50:56Z","timestamp":1758815456170},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,27]]},"abstract":"Abstract<\/jats:title>Introduction:<\/jats:title>Up to 50% of the infants delivered after radical vaginal trachelectomy (RVT) are born prematurely. An effective strategy to reduce this number could be the closure of the cervical os (CCO).<\/jats:p><\/jats:sec>Patients and methods:<\/jats:title>Fifteen pregnant patients who had a RVT due to early cervical cancer were included in this prospective case control study. All patients were scheduled for CCO early in the second trimester. CCO was performed in 12 patients. Their data were compared to data from 125 pregnancies after a RVT without CCO.<\/jats:p><\/jats:sec>Results:<\/jats:title>The patients who had CCO were compared to patients without CCO. One patient had an early rupture of the amniotic membranes prior to CCO. Two patients chose not to undergo CCO. In 12 patients CCO was performed without complications. There was no early preterm delivery in the CCO group as compared to a rate of 5% in 125 pregnancies in the non-CCO group.<\/jats:p><\/jats:sec>Discussion:<\/jats:title>We developed a protocol to reduce the risk of preterm deliveries after a RVT. Digital examinations should be avoided. Vaginal checks for pH can discover ascending infections \u2013 the main cause of preterm deliveries after a RVT. Infections should be treated adequately. CCO can further reduce the risk of preterm deliveries after a RVT.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2016-0231","type":"journal-article","created":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T10:01:29Z","timestamp":1480154489000},"source":"Crossref","is-referenced-by-count":2,"title":["Closure of the cervical os in patients after fertility preserving treatment for early cervical cancer \u2013 results of a prospective observational study"],"prefix":"10.1515","volume":"45","author":[{"given":"Mandy","family":"Mangler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Lanowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Bartens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Schindler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens-Uwe","family":"Blohmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothee","family":"Speiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11912-016-0501-5","article-title":"Can we be less radical with surgery for early cervical cancer?","volume":"18","year":"2016","journal-title":"Curr Oncol Rep."},{"key":"ref51","first-page":"192","article-title":"Case-control study of obstetrical outcomes of conisation","volume":"45","year":"2016","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"ref271","article-title":"http www who int pmnch media news pretermbirthsper births pdf","year":"2012"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/AOG.0b013e3181b5cba3","article-title":"Pregnancy outcome after treatment for cervical intraepithelial neoplasia","volume":"114","year":"2009","journal-title":"Obstet Gynecol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/AOG.0b013e3181b052de","article-title":"Loop electrosurgical excision procedure and the risk for preterm birth","volume":"114","year":"2009","journal-title":"Obstet Gynecol"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ygyno.2015.05.016","article-title":"Vaginal radical trachelectomy for early stage cervical cancer. Results of the danish national single center strategy","volume":"138","year":"2015","journal-title":"Gynecol Oncol."},{"key":"ref261","first-page":"3019","article-title":"Pregnancy outcome and obstetric management after vaginal radical trachelectomy","volume":"18","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref161","first-page":"2","article-title":"Efficient prevention of prematurity \u2013 the Thuringian model","volume":"44","year":"2004","journal-title":"Gynakol Geburtshilfliche Rundsch"},{"key":"ref151","first-page":"601","article-title":"Bacterial vaginosis","volume":"59","year":"2009","journal-title":"J Pak Med Assoc"},{"key":"ref41","article-title":"http www who int pmnch media news pretermbirthsper births pdf","year":"2012"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/AOG.0b013e3181b052de","article-title":"Loop electrosurgical excision procedure and the risk for preterm birth","volume":"114","year":"2009","journal-title":"Obstet Gynecol"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1097\/IGC.0b013e3182230294","article-title":"Fertility outcome after radical vaginal trachelectomy: a prospective study of 212 patients","volume":"21","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ccr3.84","article-title":"Successful delivery after vaginal occlusion in addition to cerclage in a trachelectomy patient with recurrent second trimester pregnancy loss: a case report","volume":"2","year":"2014","journal-title":"Clin Case Rep"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1515\/jpm-2012-0045","article-title":"Neonatal outcome in infants of patients with radical vaginal trachelectomy","volume":"40","year":"2012","journal-title":"J Perinat Med"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1097\/IGC.0b013e3182230294","article-title":"Fertility outcome after radical vaginal trachelectomy: a prospective study of 212 patients","volume":"21","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ygyno.2016.01.028","article-title":"Reproductive and oncologic outcome following robot-assisted laparoscopic radical trachelectomy for early stage cervical cancer","volume":"141","year":"2016","journal-title":"Gynecol Oncol"},{"key":"ref281","first-page":"192","article-title":"Case-control study of obstetrical outcomes of conisation","volume":"45","year":"2016","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1471-0528.2009.02438.x","article-title":"After conisation of the cervix, the perinatal mortality as a result of preterm delivery increases in subsequent pregnancy","volume":"117","year":"2010","journal-title":"Br J Obstet Gynaecol"},{"key":"ref31","first-page":"3019","article-title":"Pregnancy outcome and obstetric management after vaginal radical trachelectomy","volume":"18","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1097\/IGC.0b013e3182216aa7","article-title":"Radical vaginal trachelectomy (RVT) combined with laparoscopic lymphadenectomy: prospective study of 225 patients with early-stage cervical cancer","volume":"21","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/AOG.0b013e3181b5cba3","article-title":"Pregnancy outcome after treatment for cervical intraepithelial neoplasia","volume":"114","year":"2009","journal-title":"Obstet Gynecol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1097\/AOG.0b013e3181bf1ef2","article-title":"Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery","volume":"114","year":"2009","journal-title":"Obstet Gynecol"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1016\/S1470-2045(16)30032-8","article-title":"Oncological outcomes after fertility-sparing surgery for cervical cancer: a systematic review","volume":"17","year":"2016","journal-title":"Lancet Oncol"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/(SICI)1097-0142(20000415)88:8<1877::AID-CNCR17>3.0.CO;2-W","article-title":"Laparoscopic vaginal radical trachelectomy: a treatment to preserve the fertility of cervical carcinoma patients","volume":"88","year":"2000","journal-title":"Cancer"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ygyno.2013.07.108","article-title":"Obstetric outcomes of patients undergoing total laparoscopic radical trachelectomy for early stage cervical cancer","volume":"131","year":"2013","journal-title":"Gynecol Oncol"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s10147-014-0763-6","article-title":"Outcomes of abdominal radical trachelectomy: results of a multicenter prospective cohort study in a Tohoku gynecologic cancer unit","volume":"20","year":"2015","journal-title":"Int J Clin Oncol"},{"key":"ref201","first-page":"770","article-title":"Reproductive results of radical trachelectomy","volume":"83","year":"2015","journal-title":"Ginecol Obstet Mex"},{"key":"ref431","first-page":"770","article-title":"Reproductive results of radical trachelectomy","volume":"83","year":"2015","journal-title":"Ginecol Obstet Mex"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1016\/S1470-2045(16)30032-8","article-title":"Oncological outcomes after fertility-sparing surgery for cervical cancer: a systematic review","volume":"17","year":"2016","journal-title":"Lancet Oncol"},{"key":"ref01","first-page":"289","article-title":"Radical vaginal trachelectomy: a fertility-preserving procedure in early cervical cancer in young women","volume":"110","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ygyno.2016.01.028","article-title":"Reproductive and oncologic outcome following robot-assisted laparoscopic radical trachelectomy for early stage cervical cancer","volume":"141","year":"2016","journal-title":"Gynecol Oncol"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ygyno.2015.05.016","article-title":"Vaginal radical trachelectomy for early stage cervical cancer. Results of the danish national single center strategy","volume":"138","year":"2015","journal-title":"Gynecol Oncol."},{"key":"ref391","first-page":"2","article-title":"Efficient prevention of prematurity \u2013 the Thuringian model","volume":"44","year":"2004","journal-title":"Gynakol Geburtshilfliche Rundsch"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/(SICI)1097-0142(20000415)88:8<1877::AID-CNCR17>3.0.CO;2-W","article-title":"Laparoscopic vaginal radical trachelectomy: a treatment to preserve the fertility of cervical carcinoma patients","volume":"88","year":"2000","journal-title":"Cancer"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1515\/jpm-2012-0045","article-title":"Neonatal outcome in infants of patients with radical vaginal trachelectomy","volume":"40","year":"2012","journal-title":"J Perinat Med"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ygyno.2013.07.108","article-title":"Obstetric outcomes of patients undergoing total laparoscopic radical trachelectomy for early stage cervical cancer","volume":"131","year":"2013","journal-title":"Gynecol Oncol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1471-0528.2009.02438.x","article-title":"After conisation of the cervix, the perinatal mortality as a result of preterm delivery increases in subsequent pregnancy","volume":"117","year":"2010","journal-title":"Br J Obstet Gynaecol"},{"key":"ref381","first-page":"601","article-title":"Bacterial vaginosis","volume":"59","year":"2009","journal-title":"J Pak Med Assoc"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s10147-014-0763-6","article-title":"Outcomes of abdominal radical trachelectomy: results of a multicenter prospective cohort study in a Tohoku gynecologic cancer unit","volume":"20","year":"2015","journal-title":"Int J Clin Oncol"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11912-016-0501-5","article-title":"Can we be less radical with surgery for early cervical cancer?","volume":"18","year":"2016","journal-title":"Curr Oncol Rep."},{"key":"ref141","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1097\/IGC.0b013e3182216aa7","article-title":"Radical vaginal trachelectomy (RVT) combined with laparoscopic lymphadenectomy: prospective study of 225 patients with early-stage cervical cancer","volume":"21","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1097\/AOG.0b013e3181bf1ef2","article-title":"Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery","volume":"114","year":"2009","journal-title":"Obstet Gynecol"},{"key":"ref231","first-page":"289","article-title":"Radical vaginal trachelectomy: a fertility-preserving procedure in early cervical cancer in young women","volume":"110","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ccr3.84","article-title":"Successful delivery after vaginal occlusion in addition to cerclage in a trachelectomy patient with recurrent second trimester pregnancy loss: a case report","volume":"2","year":"2014","journal-title":"Clin Case Rep"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpme.2017.45.issue-8\/jpm-2016-0231\/jpm-2016-0231.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2016-0231\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T02:18:07Z","timestamp":1692584287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2016-0231\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":44,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.1515\/jpm-2016-0231","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,1]]}}}