{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:15:28Z","timestamp":1790129728755,"version":"4.0.1"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2016-0341_s_999_w2aab3b7b6b1b6b1aab1c15b1Aa\">\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>A current descriptive assessment of perinatal outcomes in pregnancies complicated by previable preterm premature rupture of membranes (pPPROM) at &lt;24 weeks of gestation, after expectant treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2016-0341_s_998_w2aab3b7b6b1b6b1aab1c15b2Aa\">\n                  <jats:title>Study design:<\/jats:title>\n                  <jats:p>Maternal and short-term neonatal data were collected for patients with pPPROM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2016-0341_s_997_w2aab3b7b6b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Seventy-three patients with 93 fetuses were hospitalized with pPPROM at 15\u201324 weeks\u2019 gestation. Among these patients, 27.4% (n=20) chose pregnancy termination, 27.4% (n=20) miscarried and 45.2% (n=33) proceeded to live births. After a median latency period of 38 days, ranging from 1 to 126 days, 24 singletons and 20 multiples were live-born, of whom 79.5% (n=35) survived the perinatal period. The main neonatal sequelae were pulmonary hypoplasia (29.5%; n=13), connatal infection (56.8%; n=25), intraventricular hemorrhage (25%; n=11; resulting in five neonatal deaths) and Potter\u2019s syndrome (15.9%; n=7). Nine newborns died, within an average of 2.8 days (range, 1\u201310 days). The overall neonatal survival rate was 51.5% \u2013 including miscarriages but not elective terminations. The intact survival rate was 45.5% of all live-born neonates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2016-0341_s_996_w2aab3b7b6b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Even with limited treatment options, overall neonatal survival is increasing. However, neonatal mortality and morbidity rates remain high. The gestational age at membrane rupture does not predict neonatal outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2016-0341","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T13:12:36Z","timestamp":1503321156000},"page":"555-565","source":"Crossref","is-referenced-by-count":36,"title":["Perinatal outcomes after previable preterm premature rupture of membranes before 24 weeks of gestation"],"prefix":"10.1515","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1356-9576","authenticated-orcid":false,"given":"Verena","family":"Kiver","sequence":"first","affiliation":[{"name":"Department of Obstetrics , Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Charit\u00e9 Campus Mitte , Charit\u00e9platz 1 , 10117 Berlin , Germany , Tel.: +49 (030) 450 664487"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinzenz","family":"Boos","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Henrich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Weichert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,8,19]]},"reference":[{"key":"2021021321395551698_j_jpm-2016-0341_ref_001_w2aab3b7b6b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Yeast JD. 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