{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:09:07Z","timestamp":1759565347587,"version":"3.37.3"},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2016-0380_s_999\"><jats:title id=\"d4759861e23379\">Objective:<\/jats:title><jats:p>To investigate whether fetal pulmonary artery acceleration to ejection time (PATET) ratio can predict or rule out subsequent diagnosis of transient tachypnea of the newborn (TTN).<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2016-0380_s_998\"><jats:title id=\"d4759861e23387\">Methods:<\/jats:title><jats:p>This prospective cohort study included 105 pregnant women in labor, who met the inclusion criteria. Eighteen of these women were removed from the study cohort, because of an inability to acquire sufficient Doppler waveforms and a longer duration of deliveries. According to subsequent diagnosis of TTN in the neonate, the two groups were constituted, TTN+ and TTN\u2212.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2016-0380_s_997\"><jats:title id=\"d4759861e23395\">Results:<\/jats:title><jats:p>There were no statistically significant differences between the groups regarding maternal obstetric and demographic features. The neonatal intensive care unit (NICU) submission rate was significantly higher in the TTN+ group (100%, 17%, P&lt;0.0001, respectively). Regarding the fetal pulmonary artery Doppler findings, PATET ratio in the TTN+ group was significantly lower than the TTN\u2212 group (0.307 vs. 0.389, P&lt;0.0001, respectively). The PATET ratio and diagnosis of TTN were inversely correlated (r=\u22120.41, P&lt;0.001), even if adjusted for birth weight, gestational age and fetal gender (r=0.42, P=0.0021). The cut-off value of 0.319 provided 82.7% specificity, 83.3% sensitivity, 96% negative predictive value and 41.6% positive predictive value. Additionally intraobserver ICC for PATET was found to be 0.86.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2016-0380_s_996\"><jats:title id=\"d4759861e23403\">Conclusion:<\/jats:title><jats:p>The fetal PATET ratio seems to serve as a promising tool to rule out subsequent diagnosis of TTN.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2016-0380","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T16:06:04Z","timestamp":1490630764000},"page":"219-224","source":"Crossref","is-referenced-by-count":7,"title":["A non-invasive method to rule out transient tachypnea of the newborn (TTN): fetal pulmonary artery acceleration to ejection time 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Gynecol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/jcu.22219","article-title":"The role of Doppler waveforms in the fetal main pulmonary artery in the prediction of neonatal respiratory distress syndrome","volume":"43","year":"2015","journal-title":"J Clin Ultrasound"},{"key":"ref181","first-page":"245","article-title":"Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN)","volume":"39","year":"2011","journal-title":"J Perinat Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S0002-9378(96)70586-0","article-title":"Fetal branch pulmonary arterial vascular impedance during the second half of pregnancy","volume":"174","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1440-1754.1979.tb01215.x","article-title":"Is \u201ctransient tachypnoea of the newborn\u201d always a benign disease? Report of 6 babies requiring mechanical ventilation","volume":"15","year":"1979","journal-title":"J Paediatr Child Health"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1440-1754.1979.tb01215.x","article-title":"Is \u201ctransient tachypnoea of the newborn\u201d always a benign disease? Report of 6 babies requiring mechanical ventilation","volume":"15","year":"1979","journal-title":"J Paediatr Child Health"},{"key":"ref381","first-page":"1","article-title":"Births: final data for 2013","volume":"64","year":"2015","journal-title":"Natl Vital Stat Rep"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1055\/s-0032-1333132","article-title":"Acceleration time-to-ejection time ratio in fetal pulmonary artery predicts the development of neonatal respiratory distress syndrome: a prospective cohort study","volume":"30","year":"2013","journal-title":"Am J Perinatol"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"40.e1","DOI":"10.1016\/j.ajog.2010.01.075","article-title":"Acceleration\/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity","volume":"203","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"ref151","first-page":"1","article-title":"Births: final data for 2013","volume":"64","year":"2015","journal-title":"Natl Vital Stat Rep"},{"key":"ref201","first-page":"189","article-title":"Doppler ultrasound imaging: a new technique to detect lung hypoplasia before birth? Ultrasound","volume":"7","year":"1996","journal-title":"Obstet Gynecol"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1046\/j.1469-0705.2000.00006.x","article-title":"Blood flow velocity waveforms from fetal peripheral pulmonary arteries in pregnancies with preterm premature rupture of the membranes: relationship with pulmonary hypoplasia","volume":"15","year":"2000","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1046\/j.1469-0705.2000.00006.x","article-title":"Blood flow velocity waveforms from fetal peripheral pulmonary arteries in pregnancies with preterm premature rupture of the membranes: relationship with pulmonary hypoplasia","volume":"15","year":"2000","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/hrt.58.1.15","article-title":"Acceleration time in the aorta and pulmonary artery measured by Doppler echocardiography in the midtrimester normal human fetus","volume":"58","year":"1987","journal-title":"Br Heart J"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3109\/14767058.2013.766707","article-title":"Nasal intermittent mandatory ventilation versus nasal continuous positive airway pressure for transient tachypnea of newborn: a randomized, prospective study","volume":"26","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref401","first-page":"1004","article-title":"A comparison of the accuracy of the TDx-FLM assay, lecithin-sphingomyelin ratio, and phosphatidylglycerol in the prediction of neonatal respiratory distress syndrome","volume":"82","year":"1993","journal-title":"Obstet Gynecol"},{"key":"ref171","first-page":"1004","article-title":"A comparison of the accuracy of the TDx-FLM assay, lecithin-sphingomyelin ratio, and phosphatidylglycerol in the prediction of neonatal respiratory distress syndrome","volume":"82","year":"1993","journal-title":"Obstet Gynecol"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0301-2115(98)00327-3","article-title":"Pulmonary arterial Doppler velocimetry in fetuses with lung hypoplasia","volume":"84","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1469-0705.1998.11030173.x","article-title":"Doppler echocardiography of the main stems of the pulmonary arteries in the normal human fetus","volume":"11","year":"1998","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1469-0705.1998.11030167.x","article-title":"Doppler waveforms from the pulmonary arterial system in normal fetuses and those with pulmonary hypoplasia","volume":"11","year":"1998","journal-title":"Ultrasound Obstet 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