{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:25:38Z","timestamp":1757705138963},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fetal malformations are more frequent in twins than in singletons. The aim of our study was to define the influence of a malformed twin on di-chorionic pregnancy outcomes. We performed a retrospective cohort study of di-chorionic pregnancies delivered between 2000 and 2015. Exclusion criteria were: both twins affected by fetal malformations, double intra-uterine fetal death in pregnancies without fetal malformation, selective feticide and therapeutic pregnancy termination. We compared maternal and fetal outcomes of di-chorionic pregnancies not complicated by fetal malformations with pregnancies affected by a single malformed fetus with conservative management. We included 642 di-chorionic pregnancies: 56 (case group, 8.7%) with one twin affected by a malformation (20 minor, 36 major ones), 586 (control group, 91.3%) without fetal malformation. No differences were found on maternal and not malformed co-twin outcomes when compared to pregnancies with no malformation; case vs control group presented similar rates of preeclampsia (8.9% vs. 10.8%, respectively), intrauterine growth restriction (7.1% vs. 9.4%) and composite adverse neonatal outcomes (19.6% vs. 15.1%). No case of fetal death in not malformed co-twin was reported. Expectant management could be a safe option for both mother and co-twin in case of di-chorionic twin pregnancy complicated by only one malformed fetus.<\/jats:p>","DOI":"10.1515\/jpm-2017-0032","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T10:02:50Z","timestamp":1499940170000},"page":"721-727","source":"Crossref","is-referenced-by-count":4,"title":["Expectant management in di-chorionic pregnancies complicated by discordant anomalous twin"],"prefix":"10.1515","volume":"46","author":[{"given":"Paola","family":"Algeri","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Milano-Bicocca , MBBM Foundation, S. Gerardo Hospital , Monza , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca M.","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Milano-Bicocca , MBBM Foundation, S. Gerardo Hospital , Monza , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddalena","family":"Incerti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Milano-Bicocca , MBBM Foundation, S. Gerardo Hospital , Monza , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Milano-Bicocca , MBBM Foundation, S. Gerardo Hospital , Monza , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pelizzoni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Milano-Bicocca , MBBM Foundation, S. Gerardo Hospital , Monza , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davido P.","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, Center of Biostatistics for Clinical Epidemiology , University of Milan-Bicocca , Monza, Monza e Brianza , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Montanelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Milano-Bicocca , MBBM Foundation, S. Gerardo Hospital , Monza , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Milano-Bicocca , MBBM Foundation, S. 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