{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:46:07Z","timestamp":1792115167529,"version":"4.4.0"},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"6","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2017-0040_s_999\"><jats:title id=\"d1571838e15086\">Objective:<\/jats:title><jats:p>To analyze data from a registry of Japanese neonates with hypoxic respiratory failure associated with pulmonary hypertension (PH) to compare the effectiveness of inhaled nitric oxide (iNO) in neonates born &lt;34 weeks vs. \u226534 weeks gestational age (GA).<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0040_s_998\"><jats:title id=\"d1571838e15094\">Materials and methods:<\/jats:title><jats:p>iNO was administered according to approved Japanese product labeling. Study data were collected before iNO administration and at predefined intervals until discontinuation.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0040_s_997\"><jats:title id=\"d1571838e15102\">Results:<\/jats:title><jats:p>A total of 1,114 neonates were included (n=431, &lt;34 weeks GA; n=675, \u226534 weeks GA; n=8, missing age data). Mean decrease from baseline oxygenation index (OI) was similar in both age groups. OI reduction was more pronounced in the &lt;34 weeks subgroups with baseline OI \u226525. Survival rates were similar in the &lt;34 weeks GA and \u226534 weeks GA groups stratified by baseline OI (OI&lt;15, 89% vs. 93%; 15\u2264OI&lt;25, 85% vs. 91%; 25\u2264OI\u226440, 73% vs. 79%; OI&gt;40, 64% vs. 66%).<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0040_s_996\"><jats:title id=\"d1571838e15110\">Conclusion:<\/jats:title><jats:p>iNO improved oxygenation in preterm neonates as effectively as in late preterm and term neonates, without negative impact on survival. If clinically significant PH is present, as measured by pulse oximetry or echocardiography, a therapeutic trial of iNO might be indicated for preterm neonates.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2017-0040","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T10:01:44Z","timestamp":1505815304000},"page":"657-663","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience"],"prefix":"10.1515","volume":"46","author":[{"given":"Satoshi","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Togari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim L.","family":"Potenziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref11","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.CIR.83.6.2038","article-title":"Inhaled nitric oxide. 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