{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T22:03:54Z","timestamp":1780869834910,"version":"3.54.1"},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2017-0074_s_999\"><jats:title id=\"d4759861e48503\">Objective:<\/jats:title><jats:p>To investigate the role of adjuvant 17-\u03b1-hydroxy-progesterone caproate (17OHP-C) in reducing the risk of preterm delivery &lt;34 weeks and adverse perinatal outcomes in women with \u22653 second trimester pregnancy losses attributed to cervical insufficiency undergoing prophylactic cerclage.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0074_s_998\"><jats:title id=\"d4759861e48511\">Material and methods:<\/jats:title><jats:p>Retrospective cohort study of women with prophylactic cerclage placed between 2006 and 2014 divided into a cohort of (i) those receiving adjuvant 17OHP-C (n=43), and (ii) controls with cerclage alone (n=59).<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0074_s_997\"><jats:title id=\"d4759861e48519\">Results:<\/jats:title><jats:p>Demographic characteristics were comparable in both groups. There was no significant difference in gestational age at delivery between the cerclage-17OHP-C group (33.4\u00b15.6 weeks) and the cerclage-alone group (34.4\u00b14.6 weeks); P=0.33. We noted a non-significant increase for deliveries &lt;34 weeks in the cerclage-17OHP-C group (44.2%) compared to controls (28.8%) which remained non-significant after adjusting for confounders; P=0.46. There was no statistically significant difference in the rate of delivery &lt;37, 32, 28 and 24 weeks. Adverse neonatal outcomes were comparable in both groups (cerclage-17OHP-C 48.8% vs. cerclage-alone 39%); P=0.43.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0074_s_996\"><jats:title id=\"d4759861e48527\">Conclusion:<\/jats:title><jats:p>Intramuscular 17OHP-C in combination with prophylactic cerclage in women with cervical insufficiency and \u22653 second trimester pregnancy losses had no synergistic effect in reducing the rate of recurrent preterm birth or improving perinatal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2017-0074","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T10:07:53Z","timestamp":1501236473000},"page":"155-161","source":"Crossref","is-referenced-by-count":10,"title":["Adjuvant administration of 17-\u03b1-hydroxy-progesterone caproate in women with three or more second trimester pregnancy losses undergoing cervical cerclage is no more effective than cerclage alone"],"prefix":"10.1515","volume":"46","author":[{"given":"Fernand D.","family":"Samson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Merriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle L.","family":"Tate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Apostolakis-Kyrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref231","doi-asserted-by":"crossref","first-page":"485.e1","DOI":"10.1016\/j.ajog.2014.10.1097","article-title":"17 alpha-hydroxyprogesterone caproate does not prolong pregnancy or reduce the rate of preterm birth in women at high risk for 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Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate","volume":"348","year":"2003","journal-title":"N Engl J Med."},{"key":"ref161","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1515\/jpm-2012-0272","article-title":"A blueprint for the prevention of preterm birth: vaginal progesterone in women with a short cervix","volume":"41","year":"2013","journal-title":"J Perinat Med"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1056\/NEJMoa035140","article-title":"National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate","volume":"348","year":"2003","journal-title":"N Engl J Med."}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpme.2018.46.issue-2\/jpm-2017-0074\/jpm-2017-0074.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2017-0074\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T18:37:00Z","timestamp":1750790220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2017-0074\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,23]]},"references-count":46,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1515\/jpm-2017-0074","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2,23]]}}}