{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:05:07Z","timestamp":1773173107014,"version":"3.50.1"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2017-0106_s_999\">\n                  <jats:title>Aims:<\/jats:title>\n                  <jats:p>To evaluate maternal complications of first trimester and second trimester termination of pregnancy (TOP) performed after first or second trimester positive prenatal diagnosis (PD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0106_s_998\">\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>We performed a retrospective study from January 2007 to December 2011, on 844 patients, who underwent a TOP after positive amniocentesis or chorionic villus sampling (CVS) for foetal aneuploidies, performed for maternal age \u226535 years of age, positive prenatal screening (PS) or for genetic reasons. Exclusions criteria were gestational age &gt;22+0 weeks, twin pregnancy and co-existing maternal pathologies. We compared maternal complications of first trimester and second trimester TOP and we established which risk factors were correlated to higher maternal complications (haemorrhages, transfusion, repeated uterine curettage and infections). Maternal complications were significantly higher in second trimester TOP. Previous uterine surgery is a significant risk factor for maternal complications in second trimester TOP, but not in first trimester TOP. Six uterine ruptures and three hysterectomies occurred, all in multiparous women with second trimester TOP. All uterine ruptures occurred in women with previous caesarean sections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0106_s_997\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>First trimester TOP in women with risks factors for maternal complications guarantees better maternal outcomes and less health costs. Thus, in these women we should prefer a first trimester PS and PD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2017-0106","type":"journal-article","created":{"date-parts":[[2017,10,21]],"date-time":"2017-10-21T10:01:58Z","timestamp":1508580118000},"page":"373-378","source":"Crossref","is-referenced-by-count":15,"title":["Maternal outcomes in first and second trimester termination of pregnancy: which are the risk factors?"],"prefix":"10.1515","volume":"46","author":[{"given":"Giulia","family":"Garofalo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Turin , Sant\u2019Anna Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-9805","authenticated-orcid":false,"given":"Anna","family":"Garofalo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Turin , Sant\u2019Anna Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Sochirca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Turin , Sant\u2019Anna Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Alemanno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Turin , Sant\u2019Anna Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Pilloni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Turin , Sant\u2019Anna Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilisa","family":"Biolcati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Turin , Sant\u2019Anna Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Muccinelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Turin , Sant\u2019Anna Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Viora","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Turin , Sant\u2019Anna Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tullia","family":"Todros","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Turin , Sant\u2019Anna Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,10,21]]},"reference":[{"key":"2022012815324258889_j_jpm-2017-0106_ref_001","unstructured":"Legge 22 maggio 1978, n. 194 \u2013 Norme per la tutela sociale della maternit\u00e0 e sull\u2018interruzione volontaria della gravidanza. http:\/\/www.salute.gov.it\/imgs\/c_17_normativa_845_allegato.pdf."},{"key":"2022012815324258889_j_jpm-2017-0106_ref_002","doi-asserted-by":"crossref","unstructured":"Kulier R, G\u00fclmezoglu M, Hofmeyr GJ, Cheng LN, Campana A. 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