{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:50:47Z","timestamp":1784170247954,"version":"3.55.0"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2017-0176_s_999_w2aab3b7c26b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Birth-weight is an important determinant of perinatal outcome with low birth-weight being a particular risk factor for adverse consequences.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0176_s_998_w2aab3b7c26b1b6b1aab1c16b2Aa\">\n                  <jats:title>Aim:<\/jats:title>\n                  <jats:p>To investigate the impact of neonatal sex, mode of birth and gestational age at birth according to birth-weight centile on serious adverse neonatal outcomes in singleton term pregnancies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0176_s_997_w2aab3b7c26b1b6b1aab1c16b3Aa\">\n                  <jats:title>Materials and methods:<\/jats:title>\n                  <jats:p>This was a retrospective cohort study of singleton term births at the Mater Mother\u2019s Hospital, Brisbane, Australia. Serious adverse neonatal outcome was defined as a composite of severe acidosis at birth (pH \u22647.0 and\/or lactate \u22656 mmol\/L and\/or base excess \u2264\u221212 mmol\/L), Apgar &lt;3 at 5 min, neonatal intensive-care unit admission and antepartum or neonatal death. The main exposure variable was birth-weight centile.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0176_s_996_w2aab3b7c26b1b6b1aab1c16b4Aa\">\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Of the 69,210 babies in our study, the overall proportion of serious adverse neonatal outcomes was 9.1% (6327\/69,210). Overall, neonates in the &lt;3<jats:sup>rd<\/jats:sup> birth-weight centile category had the highest adjusted odds ratio (OR) for serious adverse neonatal outcomes [OR 3.53, 95% confidence interval (CI) 3.06\u20134.07], whilst those in the \u226597<jats:sup>th<\/jats:sup> centile group also had elevated odds (OR 1.51, 95% CI 1.30\u20131.75). Regardless of birth modality, smaller babies in the &lt;3<jats:sup>rd<\/jats:sup> centile group had the highest adjusted OR and predicted probability for serious adverse neonatal outcomes. When stratified by sex, male babies consistently demonstrated a higher predicted probability of serious adverse neonatal outcomes across all birth-weight centiles. The adjusted odds, when stratified by gestational age at birth, were the highest from 37+0 to 38+6 weeks in the &lt;3<jats:sup>rd<\/jats:sup> centile group (OR 5.97, 95% CI 4.60\u20137.75).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0176_s_995_w2aab3b7c26b1b6b1aab1c16b5Aa\">\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Low and high birth-weights are risk factors for serious adverse neonatal outcomes. The adjusted OR appears to be greatest for babies in the &lt;3<jats:sup>rd<\/jats:sup> birth-weight centile group, although an elevated risk was also found in babies within the \u226597<jats:sup>th<\/jats:sup> centile category.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2017-0176","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T22:47:25Z","timestamp":1513723645000},"page":"1048-1056","source":"Crossref","is-referenced-by-count":40,"title":["Birth-weight centiles and the risk of serious adverse neonatal outcomes at term"],"prefix":"10.1515","volume":"46","author":[{"given":"Joanna","family":"Yu","sequence":"first","affiliation":[{"name":"Mater Research Institute , University of Queensland , Level 3 Aubigny Place, Raymond Terrace , South Brisbane, Queensland 4101 , Australia"},{"name":"School of Medicine , The University of Queensland , Herston, Queensland , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Flatley","sequence":"additional","affiliation":[{"name":"Mater Research Institute , University of Queensland , Level 3 Aubigny Place, Raymond Terrace , South Brisbane, Queensland 4101 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ristan M.","family":"Greer","sequence":"additional","affiliation":[{"name":"Mater Research Institute , University of Queensland , Level 3 Aubigny Place, Raymond Terrace , South Brisbane, Queensland 4101 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Mater Research Institute , University of Queensland , Level 3 Aubigny Place, Raymond Terrace , South Brisbane, Queensland 4101 , Australia"},{"name":"School of Medicine , The University of Queensland , Herston, Queensland , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"2021021320254379735_j_jpm-2017-0176_ref_001_w2aab3b7c26b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Prior T, Paramasivam G, Bennett P, Kumar S. Are fetuses that fail to achieve their growth potential at increased risk of intrapartum compromise? Ultrasound Obstet Gynecol. 2015;46:460\u20134.","DOI":"10.1002\/uog.14758"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_002_w2aab3b7c26b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Smeeton NC, Rona RJ, Dobson P, Cochrane R, Wolfe C. Assessing the determinants of stillbirths and early neonatal deaths using routinely collected data in an inner city area. BMC Med. 2004;2:27.","DOI":"10.1186\/1741-7015-2-27"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_003_w2aab3b7c26b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Francis JH, Permezel M, Davey MA. Perinatal mortality by birthweight centile. Aust N Z J Obstet Gynaecol. 2014;54:354\u20139.","DOI":"10.1111\/ajo.12205"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_004_w2aab3b7c26b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Lindqvist PG, Molin J. Does antenatal identification of small-for-gestational age fetuses significantly improve their outcome? Ultrasound Obstet Gynecol. 2005;25:258\u201364.","DOI":"10.1002\/uog.1806"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_005_w2aab3b7c26b1b6b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Sovio U, White IR, Dacey A, Pasupathy D, Smith GC. Screening for fetal growth restriction with universal third trimester ultrasonography in nulliparous women in the Pregnancy Outcome Prediction (POP) study: a prospective cohort study. Lancet. 2015;386:2089\u201397.","DOI":"10.1016\/S0140-6736(15)00131-2"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_006_w2aab3b7c26b1b6b1ab2b2b6Aa","doi-asserted-by":"crossref","unstructured":"Hirst JE, Villar J, Victora CG, Papageorghiou AT, Finkton D, Barros FC, et al. The antepartum stillbirth syndrome: risk factors and pregnancy conditions identified from the INTERGROWTH-21st Project. BJOG: Int J Obstet Gynecol. 2016. DOI: 10.1111\/1471-0528.14463.","DOI":"10.1111\/1471-0528.14463"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_007_w2aab3b7c26b1b6b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Esakoff TF, Cheng YW, Sparks TN, Caughey AB. The association between birthweight 4000g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus. Am J Obstet Gynecol. 2009;200:1\u20134.","DOI":"10.1016\/j.ajog.2009.02.035"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_008_w2aab3b7c26b1b6b1ab2b2b8Aa","unstructured":"Dowdall D, Flatley C, Kumar S. Birth-weight centiles and intrapartum compromise. J Matern Fetal Neonatal Med. 2016;20:1\u20137."},{"key":"2021021320254379735_j_jpm-2017-0176_ref_009_w2aab3b7c26b1b6b1ab2b2b9Aa","doi-asserted-by":"crossref","unstructured":"Cole TJ, Hey E, Richmond S. The PREM score: a graphical tool for predicting survival in very preterm births. Arch Dis Child Fetal Neonatal Ed. 2010;95:F14\u201319.","DOI":"10.1136\/adc.2009.164533"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_010_w2aab3b7c26b1b6b1ab2b2c10Aa","doi-asserted-by":"crossref","unstructured":"Dobbins TA, Sullivan EA, Roberts CL, Simpson JM. Australian national birthweight percentiles by sex and gestational age, 1998\u20132007. Med J Aust. 2012;197:291\u20134.","DOI":"10.5694\/mja11.11331"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_011_w2aab3b7c26b1b6b1ab2b2c11Aa","doi-asserted-by":"crossref","unstructured":"Weissmann-Brenner A, Simchen MJ, Zilberberg E, Kalter A, Weisz B, Achiron R, et al. Maternal and neonatal outcomes of macrosomic pregnancies. Med Sci Monit. 2012;18:77\u201381.","DOI":"10.12659\/MSM.883340"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_012_w2aab3b7c26b1b6b1ab2b2c12Aa","doi-asserted-by":"crossref","unstructured":"Grace L, Greer RM, Kumar S. Perinatal consequences of a category 1 caesarean section at term. BMJ Open. 2015;5:e007248. DOI: 10.1136\/bmjopen-2014-007248.","DOI":"10.1136\/bmjopen-2014-007248"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_013_w2aab3b7c26b1b6b1ab2b2c13Aa","doi-asserted-by":"crossref","unstructured":"Ju H, Chadha Y, Donovan T, O\u2019Rourke P. Fetal macrosomia and pregnancy outcomes. Aust N Z J Obstet Gynaecol. 2009;49:504\u20139.","DOI":"10.1111\/j.1479-828X.2009.01052.x"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_014_w2aab3b7c26b1b6b1ab2b2c14Aa","doi-asserted-by":"crossref","unstructured":"Stevenson DK, Verter J, Fanaroff AA, Oh W, Ehrenkranz RA, Shankaran S, et al. Sex differences in outcomes of very low birthweight infants: the newborn male disadvantage. Arch Dis Child Fetal Neonatal Ed. 2000;83:182\u20135.","DOI":"10.1136\/fn.83.3.F182"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_015_w2aab3b7c26b1b6b1ab2b2c15Aa","doi-asserted-by":"crossref","unstructured":"Clifton V. Review: sex and the human placenta: mediating differential strategies of fetal growth and survival. Placenta 2010;31:33\u20139.","DOI":"10.1016\/j.placenta.2009.11.010"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_016_w2aab3b7c26b1b6b1ab2b2c16Aa","doi-asserted-by":"crossref","unstructured":"Flatley C, Greer RM, Kumar S. The magnitude of change in the fetal cerebroplacental ratio in the third trimester and the risk of adverse pregnancy outcome. Ultrasound Obstet Gynecol 2017;50:514\u20139.","DOI":"10.1002\/uog.17371"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_017_w2aab3b7c26b1b6b1ab2b2c17Aa","doi-asserted-by":"crossref","unstructured":"Khalil AA, Morales-Rosello J, Morlando M, Hannan H, Bhide A, Papageorghiou A, et al. Is fetal cerebroplacental ratio an independent predictor of intrapartum fetal compromise and neonatal unit admission? Am J Obstet Gynecol. 2015;213:1\u201310.","DOI":"10.1016\/j.ajog.2014.10.024"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_018_w2aab3b7c26b1b6b1ab2b2c18Aa","doi-asserted-by":"crossref","unstructured":"Benton SJ, McCowan LM, Heazell AE, Grynspan D, Hutcheon JA, Senger C, et al. Placental growth factor as a marker of fetal growth restriction caused by placental dysfunction. Placenta. 2016;42:1\u20138.","DOI":"10.1016\/j.placenta.2016.03.010"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_019_w2aab3b7c26b1b6b1ab2b2c19Aa","doi-asserted-by":"crossref","unstructured":"Bligh LN, Greer RM, Kumar S. The relationship between maternal placental growth factor levels and intrapartum fetal compromise. Placenta. 2016;48:63\u20137.","DOI":"10.1016\/j.placenta.2016.10.007"},{"key":"2021021320254379735_j_jpm-2017-0176_ref_020_w2aab3b7c26b1b6b1ab2b2c20Aa","doi-asserted-by":"crossref","unstructured":"Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O\u2019Sullivan F, Burton PR, et al. Antepartum risk factors for newborn encephalopathy: The Western Australian case-control study. Br Med J. 1998;317:1549\u201353.","DOI":"10.1136\/bmj.317.7172.1549"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpme.2018.46.issue-9\/jpm-2017-0176\/jpm-2017-0176.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2017-0176\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2017-0176\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:34:57Z","timestamp":1619055297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2017-0176\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,19]]},"references-count":20,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,12,19]]},"published-print":{"date-parts":[[2018,11,27]]}},"alternative-id":["10.1515\/jpm-2017-0176"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2017-0176","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12,19]]}}}