{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:05:30Z","timestamp":1790679930986,"version":"4.1.0"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2017-0192_s_999_w2aab3b7c19b1b6b1aab1c17b1Aa\"><jats:title>Objective<\/jats:title><jats:p>To determine the frequency of sepsis and other adverse neonatal outcomes in women with a clinical diagnosis of chorioamnionitis.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0192_s_998_w2aab3b7c19b1b6b1aab1c17b2Aa\"><jats:title>Methods<\/jats:title><jats:p>We performed a secondary analysis of a multi-center placebo-controlled trial of vitamins C\/E to prevent preeclampsia in low risk nulliparous women. Clinical chorioamnionitis was defined as either the \u201cclinical diagnosis\u201d of chorioamnionitis or antibiotic administration during labor because of an elevated temperature or uterine tenderness in the absence of another cause. Early-onset neonatal sepsis was categorized as \u201csuspected\u201d or \u201cconfirmed\u201d based on a clinical diagnosis with negative or positive blood, urine or cerebral spinal fluid cultures, respectively, within 72 h of birth. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0192_s_997_w2aab3b7c19b1b6b1aab1c17b3Aa\"><jats:title>Results<\/jats:title><jats:p>Data from 9391 mother-infant pairs were analyzed. The frequency of chorioamnionitis was 10.3%. Overall, 6.6% of the neonates were diagnosed with confirmed (0.2%) or suspected (6.4%) early-onset sepsis. Only 0.7% of infants born in the setting of chorioamnionitis had culture-proven early-onset sepsis versus 0.1% if chorioamnionitis was not present. Clinical chorioamnionitis was associated with both suspected [OR 4.01 (3.16\u20135.08)] and confirmed [OR 4.93 (1.65\u201314.74)] early-onset neonatal sepsis, a need for resuscitation within the first 30 min after birth [OR 2.10 (1.70\u20132.61)], respiratory distress [OR 3.14 (2.16\u20134.56)], 1 min Apgar score of \u22643 [OR 2.69 (2.01\u20133.60)] and 4\u20137 [OR 1.71 (1.43\u20132.04)] and 5 min Apgar score of 4\u20137 [OR 1.67 (1.17\u20132.37)] (vs. 8\u201310).<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0192_s_996_w2aab3b7c19b1b6b1aab1c17b4Aa\"><jats:title>Conclusion<\/jats:title><jats:p>Clinical chorioamnionitis is common and is associated with neonatal morbidities. However, the vast majority of exposed infants (99.3%) do not have confirmed early-onset sepsis.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2017-0192","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T22:16:26Z","timestamp":1527113786000},"page":"926-933","source":"Crossref","is-referenced-by-count":49,"title":["Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis"],"prefix":"10.1515","volume":"46","author":[{"given":"Tara M.","family":"Randis","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Vagelos College of Physicians and Surgeons, Columbia University , New York, NY , USA"},{"name":"Department of Pediatrics and Microbiology , New York University School of Medicine, 317 East 34th St, Suite 902 , New York, NY 10016 , USA , Tel.: 646-754-1041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline Murguia","family":"Rice","sequence":"additional","affiliation":[{"name":"George Washington University Biostatistics Center , Washington, DC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Myatt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Cincinnati , Cincinnati, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.N.","family":"Tita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Alabama at Birmingham , Birmingham, AL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Leveno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Texas Southwestern Medical Center , Dallas, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development , Bethesda, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Varner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Utah , Salt Lake City, UT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John M.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of North Carolina at Chapel Hill , Chapel Hill, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Mercer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Case Western Reserve University-MetroHealth Medical Center , Cleveland, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara J.","family":"Dinsmoor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Northwestern University , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Ramin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Texas Health Science Center at Houston , Houston, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall W.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Brown University , Providence, RI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Samuels","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The Ohio State University , Columbus, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Sciscione","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Drexel University , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Tolosa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Oregon Health and Science University , Portland, OR , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Saade","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Texas Medical Branch , Galveston, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Wayne State University , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"2021021318310977934_j_jpm-2017-0192_ref_001_w2aab3b7c19b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Gilstrap LC 3rd, Leveno KJ, Cox SM, 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