{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:30:37Z","timestamp":1761611437647},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2017-0238_s_999_w2aab3b7c42b1b6b1aab1c16b1Aa\">\n                  <jats:title>Aim:<\/jats:title>\n                  <jats:p>In pregnancies complicated by impaired utero-placental perfusion, pentaeritrithyltetranitrate (PETN) has been shown to reduce the risk of severe fetal growth restriction (FGR) and perinatal death by 39%. The effect is most likely related to the vasodilatative influence of PETN. To assess its impact on utero-placental and fetal perfusion, we analyzed the Doppler parameters measured during the PETN pilot-trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0238_s_998_w2aab3b7c42b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>One hundred and eleven pregnancies presenting impaired utero-placental resistance at mid-gestation were included in the trial. Fifty-four women received PETN, while 57 received a placebo. Doppler velocimetry measurements were monitored biweekly. Statistical analysis was performed using a mixed linear model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0238_s_997_w2aab3b7c42b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Within the first week of treatment, the mean pulsatility index (PI) of the uterine artery (UtA) dropped more prominently in the PETN group [\u22120.20, 95% confidence interval (CI): \u22120.34 to \u22120.05, P=0.007). The adjusted relative risk (RR) for abnormal cerebro-placental ratio (CPR) was significantly reduced by PETN [RR 0.412 (95% CI: 0.181\u20130.941)]. Kaplan-Meier analysis demonstrates the postponement of absent end-diastolic flow (AED), absent or reverse end-diastolic flow (ARED), brain sparing and abnormal cerebroplacental ratio (CPR) in the PETN group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0238_s_996_w2aab3b7c42b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The demonstrated effect of PETN on utero-placental and feto-placental perfusion strengthens the evidence for a positive impact in pregnancies complicated by impaired placental perfusion and might explain the effect on neonatal outcome, as shown in the PETN-pilot trial.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2017-0238","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T22:16:40Z","timestamp":1513981000000},"page":"1004-1009","source":"Crossref","is-referenced-by-count":11,"title":["Pentaerythrityltetranitrate (PETN) improves utero- and feto-placental Doppler parameters in pregnancies with impaired utero-placental perfusion in mid-gestation \u2013 a secondary analysis of the PETN-pilot trial"],"prefix":"10.1515","volume":"46","author":[{"given":"Sandy","family":"Bowkalow","sequence":"first","affiliation":[{"name":"Department of Obstetrics , University Hospital Jena, Friedrich Schiller University , Jena , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekkehard","family":"Schleussner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , University Hospital Jena, Friedrich Schiller University , Jena , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"K\u00e4hler","sequence":"additional","affiliation":[{"name":"Prenatal Diagnostic Center , Erfurt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , University Hospital Jena, Friedrich Schiller University , Jena , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computer Science , University Hospital Jena, Friedrich Schiller University , Jena , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Groten","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , University Hospital Jena, Friedrich Schiller University , Jena , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"2021021320253983312_j_jpm-2017-0238_ref_001_w2aab3b7c42b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Gluckman PD, Hanson MA, Cooper C, Thornburg KL. 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