{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T11:23:17Z","timestamp":1701861797487},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2017-0240_s_999_w2aab3b7c49b1b6b1aab1c16b1Aa\"><jats:title>Objective:<\/jats:title><jats:p>To clarify and compare if the neurological outcomes of fetal growth restriction (FGR) cases with abnormal cord insertion (CI) are associated with a higher risk of a poor neurological outcome in subjects aged 3 years or less versus those with normal CI.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0240_s_998_w2aab3b7c49b1b6b1aab1c16b2Aa\"><jats:title>Methods:<\/jats:title><jats:p>A multicenter retrospective cohort study was conducted among patients with a birth weight lower than the 3<jats:sup>rd<\/jats:sup>percentile, based on the standard reference values for Japanese subjects after 22 weeks\u2019 gestation, who were treated at a consortium of nine perinatal centers in Japan between June 2005 and March 2011. Patients whose birth weights were less than the 3<jats:sup>rd<\/jats:sup>percentile and whose neurological outcomes from birth to 3 years of age could be checked from their medical records were analyzed. The relationship between abnormal CI and neurological outcomes was analyzed. Univariate and multivariate models of multivariate logistic regression were employed to estimate the raw and odds ratio (OR) with 95% confidence intervals comparing marginal (MCI) and velamentous cord insertion (VCI) to normal CI.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0240_s_997_w2aab3b7c49b1b6b1aab1c16b3Aa\"><jats:title>Results:<\/jats:title><jats:p>Among 365 neonates, 63 cases of MCI and 14 cases of VCI were observed. After excluding 24 cases with neonatal or infant death from the total FGR population, the assessment of the outcomes of the infants aged 3 years or younger showed the following rates of neurological complications: 7.3% (n=25) for cerebral palsy, 8.8% (n=30) for developmental disorders, 16.7% (n=57) for small-for-gestational-age short stature (SGA), 0.6% (n=2) for impaired hearing, 0.9% (n=3) for epilepsy, 1.2% (n=4). The ORs (95% confidence intervals) based on multivariate analysis were as follows: cerebral palsy=10.1 (2.4\u201341.5) in the VCI group and 4.3 (1.6\u201311.9) in the MCI group, developmental disorders=6.7 (1.7\u201326) in the VCI group and 3.9 (1.1\u201314.2) in the single umbilical artery (SUA) group, 5.1 (1.4\u201318.7) for birth weight &lt;1000 g and 2.8 (1.2\u20136.7) for placental weight &lt;200 g.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0240_s_996_w2aab3b7c49b1b6b1aab1c16b4Aa\"><jats:title>Conclusions:<\/jats:title><jats:p>The present results indicate that growth-restricted fetuses diagnosed with a birth weight below the 3<jats:sup>rd<\/jats:sup>percentile exhibiting abnormal umbilical CI are at a high risk for poor neurological outcomes, including cerebral palsy and\/or developmental disorders.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2017-0240","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T22:16:29Z","timestamp":1513894589000},"page":"1040-1047","source":"Crossref","is-referenced-by-count":5,"title":["A poor long-term neurological prognosis is associated with abnormal cord insertion in severe growth-restricted fetuses"],"prefix":"10.1515","volume":"46","author":[{"given":"Masamitsu","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Showa University School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagayoshi","family":"Umehara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Osaka Medical Center and Research Institute for Maternal and Child Health , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Sasahara","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Osaka Medical Center and Research Institute for Maternal and Child Health , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kiyoshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Hyogo Children\u2019s Hospital , Hyogo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsusuke","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Maternal and Fetal Medicine , Miyagi Children\u2019s Hospital , Miyagi , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Kyorin University Hospital , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Tanemoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Jikei University Hospital , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotake","family":"Ichizuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Showa University School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , St. Marianna University School of Medicine , Kanagawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Kanagawa Children\u2019s Medical Center , Kanagawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Murakoshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Seirei Hamamatsu General Hospital , Shizuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Osaka Medical Center and Research Institute for Maternal and Child Health , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"2021021320254268607_j_jpm-2017-0240_ref_001_w2aab3b7c49b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Misra DP, Salafia CM, Miller RK, Charles AK. Non-linear and gender-specific relationships among placental growth measures and the fetoplacental weight ratio. Placenta. 2009;30:1052\u20137.","DOI":"10.1016\/j.placenta.2009.09.008"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_002_w2aab3b7c49b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Ebbing C, Kiserud T, Johnsen SL, Albrechtsen S, Rasmussen S. Prevalence, risk factors and outcomes of velamentous and marginal cord insertions: a population-based study of 634,741 pregnancies. PLoS One. 2013;8:e70380.","DOI":"10.1371\/journal.pone.0070380"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_003_w2aab3b7c49b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Hasegawa J, Matsuoka R, Ichizuka K, Sekizawa A, Farina A, Okai T. Velamentous cord insertion into the lower third of the uterus is associated with intrapartum fetal heart rate abnormalities. Ultrasound Obstet Gynecol. 2006;27:425\u20139.","DOI":"10.1002\/uog.2645"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_004_w2aab3b7c49b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Hasegawa J, Matsuoka R, Ichizuka K, Sekizawa A, Okai T. Velamentous cord insertion: significance of prenatal detection to predict perinatal complications. Taiwan J Obstet Gynecol. 2006;45:21\u20135.","DOI":"10.1016\/S1028-4559(09)60185-6"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_005_w2aab3b7c49b1b6b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Hasegawa J, Matsuoka R, Ichizuka K, Sekizawa A, Farina A, Okai T. Velamentous cord insertion and atypical variable decelerations with no accelerations. Int J Gynaecol Obstet. 2005;90:26\u201330.","DOI":"10.1016\/j.ijgo.2005.03.028"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_006_w2aab3b7c49b1b6b1ab2b2b6Aa","doi-asserted-by":"crossref","unstructured":"Hasegawa J, Matsuoka R, Ichizuka K, Kotani M, Nakamura M, Mikoshiba T, et al. Atypical variable deceleration in the first stage of labor is a characteristic fetal heart-rate pattern for velamentous cord insertion and hypercoiled cord. J Obstet Gynaecol Res. 2009;35:35\u20139.","DOI":"10.1111\/j.1447-0756.2008.00863.x"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_007_w2aab3b7c49b1b6b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Redline RW. Clinical and pathological umbilical cord abnormalities in fetal thrombotic vasculopathy. Hum Pathol. 2004;35:1494\u20138.","DOI":"10.1016\/j.humpath.2004.08.003"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_008_w2aab3b7c49b1b6b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Kraus FT, AcheenVI. Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. Hum Pathol. 1999;30:759\u201369.","DOI":"10.1016\/S0046-8177(99)90136-3"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_009_w2aab3b7c49b1b6b1ab2b2b9Aa","doi-asserted-by":"crossref","unstructured":"Eddleman KA, Lockwood CJ, Berkowitz GS, Lapinski RH, Berkowitz RL. Clinical significance and sonographic diagnosis of velamentous umbilical cord insertion. Am J Perinatol. 1992;9:123\u20136.","DOI":"10.1055\/s-2007-994684"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_010_w2aab3b7c49b1b6b1ab2b2c10Aa","doi-asserted-by":"crossref","unstructured":"Yoshida A, Umehara N, Sasahara J, Ozawa K, Ichizuka K, Tanaka K, et al. Prenatal risk stratification of severe small-for-gestational-age infants: a Japanese multicenter study. J Matern Fetal Neonatal Med. 2016;29:1353\u20137.","DOI":"10.3109\/14767058.2015.1049147"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_011_w2aab3b7c49b1b6b1ab2b2c11Aa","doi-asserted-by":"crossref","unstructured":"Itabashi K, Miura F, Uehara R, Nakamura Y. New Japanese neonatal anthropometric charts for gestational age at birth. Pediatr Int. 2014;56:702\u20138.","DOI":"10.1111\/ped.12331"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_012_w2aab3b7c49b1b6b1ab2b2c12Aa","doi-asserted-by":"crossref","unstructured":"Visentin S, Macchi V, Grumolato F, Porzionato A, De Caro R, Cosmi E. Expectant management in type II selective intrauterine growth restriction and abnormal cord insertion in monochorionic twins. J Perinat Med. 2013;41:309\u201316.","DOI":"10.1515\/jpm-2012-0133"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_013_w2aab3b7c49b1b6b1ab2b2c13Aa","doi-asserted-by":"crossref","unstructured":"Higgins JR, de Swiet M. Blood-pressure measurement and classification in pregnancy. Lancet. 2001;357:131\u20135.","DOI":"10.1016\/S0140-6736(00)03552-2"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_014_w2aab3b7c49b1b6b1ab2b2c14Aa","doi-asserted-by":"crossref","unstructured":"Bastide A, Manning F, Harman C, Lange I, Morrison I. Ultrasound evaluation of amniotic fluid: outcome of pregnancies with severe oligohydramnios. Am J Obstet Gynecol. 1986;154:895\u2013900.","DOI":"10.1016\/0002-9378(86)90479-5"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_015_w2aab3b7c49b1b6b1ab2b2c15Aa","doi-asserted-by":"crossref","unstructured":"Bax MC. Terminology and classification of cerebral palsy. Dev Med Child Neurol. 1964;6:295\u20137.","DOI":"10.1111\/j.1469-8749.1964.tb10791.x"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_016_w2aab3b7c49b1b6b1ab2b2c16Aa","unstructured":"Society for the Kyoto Scale of Psychological Development Test. Kyodaishiki developmental schedule New edition 2001. [T.K.S.o.P.D.T. 2001]. Nakanishiya Shuppan: Kyoto, 2008. (in Japanese)"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_017_w2aab3b7c49b1b6b1ab2b2c17Aa","doi-asserted-by":"crossref","unstructured":"Leistra-Leistra MJ, Timmer A, van Spronsen FJ, Geven WB, van der Meer J, Erwich JJ. Fetal thrombotic vasculopathy in the placenta: a thrombophilic connection between pregnancy complications and neonatal thrombosis? Placenta. 2004; 25(Suppl A):S102\u20135.","DOI":"10.1016\/j.placenta.2004.01.010"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_018_w2aab3b7c49b1b6b1ab2b2c18Aa","doi-asserted-by":"crossref","unstructured":"Dahms BB, Boyd T, Redline RW. Severe perinatal liver disease associated with fetal thrombotic vasculopathy. Pediatr Dev Pathol. 2002;5:80\u20135.","DOI":"10.1007\/s10024-001-0111-5"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_019_w2aab3b7c49b1b6b1ab2b2c19Aa","unstructured":"Benirschke K. Obstetrically important lesions of the umbilical cord. J Reprod Med. 1994;39:262\u201372."},{"key":"2021021320254268607_j_jpm-2017-0240_ref_020_w2aab3b7c49b1b6b1ab2b2c20Aa","doi-asserted-by":"crossref","unstructured":"Tantbirojn P, Saleemuddin A, Sirois K, Crum CP, Boyd TK, Tworoger S, et al. Gross abnormalities of the umbilical cord: related placental histology and clinical significance. Placenta. 2009;30:1083\u20138.","DOI":"10.1016\/j.placenta.2009.09.005"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_021_w2aab3b7c49b1b6b1ab2b2c21Aa","doi-asserted-by":"crossref","unstructured":"Nelson KB, Ellenberg JH. Apgar scores as predictors of chronic neurologic disability. Pediatrics. 1981;68:36\u201344.","DOI":"10.1542\/peds.68.1.36"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_022_w2aab3b7c49b1b6b1ab2b2c22Aa","doi-asserted-by":"crossref","unstructured":"Odd DE, Lewis G, Whitelaw A, Gunnell D. Resuscitation at birth and cognition at 8 years of age: a cohort study. Lancet. 2009;373:1615\u201322.","DOI":"10.1016\/S0140-6736(09)60244-0"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_023_w2aab3b7c49b1b6b1ab2b2c23Aa","doi-asserted-by":"crossref","unstructured":"McCormick MC, Brooks-Gunn J, Buka SL, Goldman J, Yu J, Salganik M, et al. Early intervention in low birth weight premature infants: results at 18 years of age for the Infant Health and Development Program. Pediatrics. 2006;117: 771\u201380.","DOI":"10.1542\/peds.2005-1316"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_024_w2aab3b7c49b1b6b1ab2b2c24Aa","doi-asserted-by":"crossref","unstructured":"Edwards AD, Brocklehurst P, Gunn AJ, Halliday H, Juszczak E, Levene M, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. Br Med J. 2010;340:c363.","DOI":"10.1136\/bmj.c363"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_025_w2aab3b7c49b1b6b1ab2b2c25Aa","doi-asserted-by":"crossref","unstructured":"Spittle AJ, Orton J, Doyle LW, Boyd R. Early developmental intervention programs post hospital discharge to prevent motor and cognitive impairments in preterm infants. Cochrane Database Syst Rev. 2007:CD005495.","DOI":"10.1002\/14651858.CD005495.pub2"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_026_w2aab3b7c49b1b6b1ab2b2c26Aa","doi-asserted-by":"crossref","unstructured":"Paneth N, Stark RI. Cerebral palsy and mental retardation in relation to indicators of perinatal asphyxia. An epidemiologic overview. Am J Obstet Gynecol. 1983;147:960\u20136.","DOI":"10.1016\/0002-9378(83)90254-5"},{"key":"2021021320254268607_j_jpm-2017-0240_ref_027_w2aab3b7c49b1b6b1ab2b2c27Aa","doi-asserted-by":"crossref","unstructured":"Sep\u00falveda WH. Antenatal sonographic detection of single umbilical artery. J Perinat Med. 1991;19:391\u20135.","DOI":"10.1515\/jpme.1991.19.5.391"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpme.2018.46.issue-9\/jpm-2017-0240\/jpm-2017-0240.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2017-0240\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2017-0240\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:49:13Z","timestamp":1660178953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2017-0240\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,21]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,12,21]]},"published-print":{"date-parts":[[2018,11,27]]}},"alternative-id":["10.1515\/jpm-2017-0240"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2017-0240","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12,21]]}}}