{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:11:46Z","timestamp":1777446706110,"version":"3.51.4"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2017-0321_s_999_w2aab3b7c10b1b6b1aab1c15b1Aa\"><jats:title>Objective<\/jats:title><jats:p>To examine the risk for abnormal chromosomal microarray analysis (CMA) results among fetuses with an apparently isolated pelvic kidney.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0321_s_998_w2aab3b7c10b1b6b1aab1c15b2Aa\"><jats:title>Methods<\/jats:title><jats:p>Data from all CMA analyses performed due to an isolated pelvic kidney reported to the Israeli Ministry of Health between January 2013 and September 2016 were retrospectively obtained. Risk estimation was performed comparing the rate of abnormal observed CMA findings to the general population risk, based on a systematic review encompassing 9272 cases and on local data of 5541 cases.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0321_s_997_w2aab3b7c10b1b6b1aab1c15b3Aa\"><jats:title>Results<\/jats:title><jats:p>Of 120 pregnancies with an isolated pelvic kidney, two gain-of-copy number variants suggesting microduplication syndromes were demonstrated (1.67%). In addition, three variants of unknown significance were detected (2.5%).<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0321_s_996_w2aab3b7c10b1b6b1aab1c15b4Aa\"><jats:title>Conclusion<\/jats:title><jats:p>The risk for clinically significant CMA findings among pregnancies with an isolated single pelvic kidney was not significantly different compared to both control populations. The results of our study question the practice of routine CMA analysis in fetuses with an isolated pelvic kidney.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2017-0321","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T22:18:06Z","timestamp":1527718686000},"page":"30-34","source":"Crossref","is-referenced-by-count":9,"title":["Chromosomal microarray findings in pregnancies with an isolated pelvic kidney"],"prefix":"10.1515","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-2130","authenticated-orcid":false,"given":"Lena","family":"Sagi-Dain","sequence":"first","affiliation":[{"name":"Genetics Institute, Department of Obstetrics and Gynecology , Carmel Medical Center, 7 Michal St. , Haifa , Israel , Tel.: +972-506265842, Fax: +972-48258075"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amihood","family":"Singer","sequence":"additional","affiliation":[{"name":"Community Genetics, Public Health Services, Ministry of Health , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayala","family":"Frumkin","sequence":"additional","affiliation":[{"name":"Department of Genetic and Metabolic Diseases, Hadassah , Hebrew University Medical Center , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Shalata","sequence":"additional","affiliation":[{"name":"Genetics Institute, Bnai Zion Medical Center , Haifa , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Koifman","sequence":"additional","affiliation":[{"name":"Genetics Institute, Soroka Medical Center , Beer Sheva , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reeval","family":"Segel","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute , Shaare Zedek Medical Center and the Hebrew University School of Medicine , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach","family":"Benyamini","sequence":"additional","affiliation":[{"name":"Genetic Institute, Assaf Harofeh Medical Center , Zerifin , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomit","family":"Rienstein","sequence":"additional","affiliation":[{"name":"Danek Gertner Institute of Human Genetics , Tel Aviv University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morad","family":"Kahyat","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Haemek Medical Center , Afula , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reuven","family":"Sharony","sequence":"additional","affiliation":[{"name":"Genetics Institute, Meir Medical Center , Kfar Saba , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idit","family":"Maya","sequence":"additional","affiliation":[{"name":"Recanati Genetics Institute, Beilinson Hospital, Rabin Medical Center , Petach Tikva , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shay","family":"Ben Shachar","sequence":"additional","affiliation":[{"name":"Genetic Institute, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"2021021321162866009_j_jpm-2017-0321_ref_001_w2aab3b7c10b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Yuksel A, Batukan C. 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