{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:04:06Z","timestamp":1761541446653},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2017-0354_s_999_w2aab3b7c55b1b6b1aab1c16b1Aa\"><jats:title>Background<\/jats:title><jats:p>Evaluation of newborns for hypoxic ischemic encephalopathy (HIE) includes laboratory and clinical parameters, as well as amplitude integrated electroencephalogram (aEEG). Based on qualifying criteria, selective head cooling (SHC) is initiated for infants with evidence of moderate to severe HIE. However, some newborns may not qualify for hypothermia therapy based on normal aEEG.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0354_s_998_w2aab3b7c55b1b6b1aab1c16b2Aa\"><jats:title>Objective<\/jats:title><jats:p>To compare levels of serum glial fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase-1 (UCHL-1) protein and phosphorylated axonal neurofilament heavy chain (pNF-H), in newborns who met initial screening criteria for HIE but did not qualify for head cooling, to the levels in healthy newborns.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0354_s_997_w2aab3b7c55b1b6b1aab1c16b3Aa\"><jats:title>Study design<\/jats:title><jats:p>Newborns \u226536 weeks of gestational age at risk for HIE, who were evaluated but did not qualify for SHC from July 2013 through June 2014 at NYU Langone Medical Center and Bellevue Hospital center were enrolled. A control group included healthy newborns from the newborn nursery (NBN). Serum samples were collected between 24 and 48 h of life from both groups.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0354_s_996_w2aab3b7c55b1b6b1aab1c16b4Aa\"><jats:title>Results<\/jats:title><jats:p>There was no significant difference in the serum levels of GFAP, UCHL-1 protein and pNF-H between the two groups of infants.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2017-0354_s_995_w2aab3b7c55b1b6b1aab1c16b5Aa\"><jats:title>Conclusion<\/jats:title><jats:p>Newborns at risk for HIE who met the initial criteria for head cooling but who were excluded based on normal aEEG did not show significant elevation of biomarkers of brain injury compared to healthy newborns. These findings may help to validate using aEEG as an additional evaluation criteria in cooling.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2017-0354","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T22:16:38Z","timestamp":1530656198000},"page":"942-947","source":"Crossref","is-referenced-by-count":4,"title":["Serum biomarkers of neuronal injury in newborns evaluated for selective head cooling: a comparative pilot study"],"prefix":"10.1515","volume":"46","author":[{"given":"Uday P.","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology , Icahn School of Medicine at Mount Sinai and Elmhurst Hospital Center , 79-01 Broadway, A7-34 , Elmhurst, NY 11373 , USA , Tel.: +718-334-5788, Fax: +718-334-1253"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep V.","family":"Mally","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology , New York University School of Medicine , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena V.","family":"Wachtel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology , New York University School of Medicine , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"2021021318311726839_j_jpm-2017-0354_ref_001_w2aab3b7c55b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. 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