{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:53:25Z","timestamp":1793379205578,"version":"4.5.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2018-0120_s_999_w2aab3b7c30b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the first trimester maternal biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0120_s_998_w2aab3b7c30b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study was a case-control study of healthy women with singleton pregnancies at the first trimester carried out at the Obstetrics and Gynecology Unit, Clinica Davila, Santiago, Chile. After obtaining informed consent, peripheral blood samples of pregnant women under 14 weeks of gestation were collected. At 24\u201328 weeks of pregnancy, women were classified as GDM (n=16) or controls (n=80) based on the results of a 75-g oral glucose tolerance test (OGTT). In all women, we measured concentrations of fasting blood glucose, insulin, glycated hemoglobin, uric acid, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), \u03b3-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), sex hormone-binding globulin (SHBG), adiponectin, tissue plasminogen activator (t-PA), leptin and placental growth factor (PGF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0120_s_997_w2aab3b7c30b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The GDM group displayed an increased median concentration of cholesterol (P=0.04), triglycerides (P=0.003), insulin (P=0.003), t-PA (P=0.0088) and homeostatic model assessment (HOMA) (P=0.003) and an increased mean concentration of LDL (P=0.009) when compared to the control group. The receiver operating characteristic (ROC) curve for significant variables achieved an area under the curve (AUC) of 0.870, a sensitivity of 81.4% and a specificity of 80.0%. The OGTT was positive for GDM according to the IADPSG (International Diabetes in Pregnancy Study Group) criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0120_s_996_w2aab3b7c30b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Women who subsequently developed GDM showed higher levels of blood-borne biomarkers during the first trimester, compared to women who did not develop GDM. These data warrant validation in a larger cohort.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2018-0120","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T09:01:07Z","timestamp":1536224467000},"page":"161-168","source":"Crossref","is-referenced-by-count":52,"title":["First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study"],"prefix":"10.1515","volume":"47","author":[{"given":"Paula J.","family":"Correa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine , Universidad de Los Andes, San Carlos de Apoquindo 2200 , Las Condes, Santiago de Chile , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Venegas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine , Universidad de Los Andes, San Carlos de Apoquindo 2200 , Las Condes, Santiago de Chile , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasna","family":"Palmeiro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine , Universidad de Los Andes, San Carlos de Apoquindo 2200 , Las Condes, Santiago de Chile , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Albers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine , Universidad de Los Andes, San Carlos de Apoquindo 2200 , Las Condes, Santiago de Chile , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine , Universidad de Los Andes, San Carlos de Apoquindo 2200 , Las Condes, Santiago de Chile , Chile"},{"name":"Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research , UQ Centre for Clinical Research Building 71\/918, Royal Brisbane and Women\u2019s Hospital Campus, Herston, QLD , Brisbane , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Roa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Cl\u00ednica Davila, Recoleta 464 , Recoleta, Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Cortez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Cl\u00ednica Davila, Recoleta 464 , Recoleta, Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Monckeberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine , Universidad de Los Andes, San Carlos de Apoquindo 2200 , Las Condes, Santiago de Chile , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Schepeler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Cl\u00ednica Davila, Recoleta 464 , Recoleta, Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Cl\u00ednica Davila, Recoleta 464 , Recoleta, Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian E.","family":"Illanes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine , Universidad de Los Andes, San Carlos de Apoquindo 2200 , Las Condes, Santiago de Chile , Chile"},{"name":"Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research , UQ Centre for Clinical Research Building 71\/918, Royal Brisbane and Women\u2019s Hospital Campus, Herston, QLD , Brisbane , Australia"},{"name":"Department of Obstetrics and Gynaecology , Cl\u00ednica Davila, Recoleta 464 , Recoleta, Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"2021021321381704247_j_jpm-2018-0120_ref_001_w2aab3b7c30b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Buchanan T, Xiang A. 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