{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:57:57Z","timestamp":1773071877473,"version":"3.50.1"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2018-0155_s_999_w2aab3b7c47b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The objective of the study was to compare the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) dietary supplementation on their concentration in total lipids (TL) and lipid fractions of maternal and umbilical vein (UV) blood. The specific objective was to analyze the impact of EPA and DHA supplementation on pregnancy outcome and neonatal birth weight.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0155_s_998_w2aab3b7c47b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Women were randomly single-blinded (randomized controlled trial; ISRCTN36705743) allocated to the group receiving EPA and DHA supplementation (supplemented group) or the group receiving placebo-corn oil (control group) in the time period from January 1<jats:sup>st<\/jats:sup>, 2016 until March 1<jats:sup>st<\/jats:sup>, 2017. Women in the supplemented group (n=45) took 360 mg EPA and 240 mg DHA daily while controls (n=42) were given a placebo. Maternal and UV bloods were obtained at delivery. After lipid extraction, phospholipids (PL), cholesterol esters (CE), triacylglycerols (TG) and non-esterified fatty acids were separated by thin layer chromatography and analyzed by gas chromatography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0155_s_997_w2aab3b7c47b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Higher DHA concentrations in TL (37.24\u00b121.87 mg\/L), PL (13.14\u00b18.07 mg\/L) and triacylglycerols (2.24\u00b12.21 mg\/L) were recorded in mothers from the supplemented group when compared to the study group (TL 21.89\u00b114.53 mg\/L; P&lt;0.001; PL 9.33\u00b15.70 mg\/L; P=0.013; TG 0.56\u00b10.43 mg\/L; P&lt;0.001). Higher DHA concentrations in UV samples were found in TL (11.51\u00b17.34 mg\/L), PL (5.29\u00b13.31 mg\/L) and triacylglycerols (0.62\u00b10.46 mg\/L) from the supplemented groups compared with controls (TL 7.37\u00b13.60 mg\/L; P=0.002; PL 3.52\u00b12.19 mg\/L; P=0.005; TG 0.40\u00b10.46 mg\/L; P=0.035). The ratio of AA:DHA was lower in maternal (2.43) and UV serum (4.0) of the supplemented group than in the control group (maternal 3.85 P&lt;0.001; UV 4.91 P&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0155_s_996_w2aab3b7c47b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The study demonstrated the higher ratio of AA\/DHA in the control group indicating that pregnant women on the traditional Herzegovina diet need supplementation with DHA and EPA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2018-0155","type":"journal-article","created":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T13:19:51Z","timestamp":1539436791000},"page":"200-206","source":"Crossref","is-referenced-by-count":3,"title":["Effect of n-3 long-chain polyunsaturated fatty acids supplementation in healthy mothers on DHA and EPA profiles in maternal and umbilical blood: a randomized controlled trial"],"prefix":"10.1515","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-3177","authenticated-orcid":false,"given":"Dragan","family":"Soldo","sequence":"first","affiliation":[{"name":"Obstetrician and Gynecologist, Department of Obstetrics and Gynecology , Mostar Clinical Hospital Center, School of Medicine, University of Mostar , Mostar , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matija","family":"Mikuli\u0107-Kaji\u0107","sequence":"additional","affiliation":[{"name":"Specialist in Obstetrics and Gynecology at Health Center , Siroki Brijeg , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Spalldi Bari\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Director of Ian Donald Inter-University School of Medical Ultrasound, Croatian Branch, and Specialist in Obstetrics and Gynecology at Private Clinic Veritas d.o.o , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolina","family":"Penava","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Mostar Clinical Hospital Center, School of Medicine, University of Mostar , Mostar , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Orlovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Mostar Clinical Hospital Center, School of Medicine, University of Mostar , Mostar , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neven","family":"Soldo","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Mostar , Mostar , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kaji\u0107","sequence":"additional","affiliation":[{"name":"Department of Surgery , Mostar Clinical Hospital Center, School of Medicine, University of Mostar , Mostar , Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,10,13]]},"reference":[{"key":"2021021321381321289_j_jpm-2018-0155_ref_001_w2aab3b7c47b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Witte AV, Kerti L, Hermannstadter HM, Fiebach JB, Schreiber SJ, Schuchardt JP, et al. 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