{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:44:02Z","timestamp":1777092242411,"version":"3.51.4"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2018-0201_s_999_w2aab3b7b9b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare the level of oxidative deoxyribonucleic acid (DNA) damage (genotoxicity) between the offspring of mothers with and without diabetes diagnosed during pregnancy and its association with maternal body mass index (BMI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0201_s_998_w2aab3b7b9b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We measured 8-hydroxy-deoxyguanosine (8-OH-dG), a marker of DNA oxidative damage, in venous umbilical cord plasma from newborns of mothers with (n=34) and without (n=56) diabetes diagnoses obtained during pregnancy. Two markers of oxidative stress \u2013 namely, nitric oxide degradation products (NOx) and total glutathione (GSH) \u2013 were quantified in both mothers and newborns. The effects of BMI, glycated hemoglobin (HbA<jats:sub>1c<\/jats:sub>), age and delivery mode were also analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0201_s_997_w2aab3b7b9b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Newborns of mothers with diabetes during pregnancy exhibited higher levels of 8-OH-dG than those of mothers without diabetes (P&lt;0.001). The other markers of oxidative stress were also higher in both mothers with diabetes and their newborns, with the exception of NOx in the mothers. The association of diabetes with 8-OH-dG was independent of other analyzed factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0201_s_996_w2aab3b7b9b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The offspring of mothers with diabetes during pregnancy are born with increased genotoxicity than the offspring of mothers without diabetes. BMI and HbA<jats:sub>1c<\/jats:sub> display an independent association with 8-OH-dG, particularly in the offspring of mothers not diagnosed with diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2018-0201","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T09:01:08Z","timestamp":1545123668000},"page":"347-353","source":"Crossref","is-referenced-by-count":9,"title":["Diabetes and obesity during pregnancy are associated with oxidative stress genotoxicity in newborns"],"prefix":"10.1515","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-0105","authenticated-orcid":false,"given":"Mar\u00eda F.","family":"Castilla-Peon","sequence":"first","affiliation":[{"name":"Research Division , Hospital Infantil de M\u00e9xico Federico G\u00f3mez , Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-0203","authenticated-orcid":false,"given":"Patricia Guadalupe","family":"Medina Bravo","sequence":"additional","affiliation":[{"name":"Endocrinology Department , Hospital Infantil de M\u00e9xico Federico G\u00f3mez , Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"S\u00e1nchez-Urbina","sequence":"additional","affiliation":[{"name":"Research Unit in Congenital Heart Diseases , Hospital Infantil de M\u00e9xico Federico G\u00f3mez , Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Gallardo-Montoya","sequence":"additional","affiliation":[{"name":"Research Unit in Renal Diseases, Centro M\u00e9dico Nacional \u201cSiglo XXI\u201d , Instituto Mexicano del Seguro Social , Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis C\u00e9sar","family":"Soriano-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Research Unit in Congenital Heart Diseases , Hospital Infantil de M\u00e9xico Federico G\u00f3mez , Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto Mois\u00e9s","family":"Coronel Cruz","sequence":"additional","affiliation":[{"name":"Materno-Fetal Medicine Unit, Obstetrics and Gynecology Department , Hospital General de M\u00e9xico Eduardo Liceaga O.D. , Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"2023033123573026747_j_jpm-2018-0201_ref_001_w2aab3b7b9b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. 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