{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:11:07Z","timestamp":1785499867432,"version":"3.56.0"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2018-0286_s_999_w2aab2b8c26b1b7b1aab1c17b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is little available data on fetal monocyte phenotype and function. A prospective cross-sectional pilot study was conducted to describe the cord blood monocyte subset phenotype in preeclampsia (PE) and fetal growth restriction (FGR) as compared to normal pregnancy and maternal circulation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0286_s_998_w2aab2b8c26b1b7b1aab1c17b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Maternal and cord blood samples from 27 pregnancies were collected at delivery from normal pregnancy, PE, FGR and PE+FGR. The distribution of fetal monocyte subtypes was characterized by CD14 and CD16 expression using flow cytometry and compared for each clinical group using a classification of classical, intermediate and non-classical subsets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0286_s_997_w2aab2b8c26b1b7b1aab1c17b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The intermediate monocytes were the dominant monocyte subset in the cord blood of PE and PE+FGR with an increase in the combined inflammatory monocyte subsets intermediate and non-classical in PE compared to normal pregnancy. The non-classical monocyte subset proportion was elevated in all pathological groups PE, FGR and PE+FGR. A significant reduction in the non-classical monocyte subset was observed in the cord blood of the normal pregnancy group as compared to the maternal circulation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0286_s_996_w2aab2b8c26b1b7b1aab1c17b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study describes for the first time in the fetal circulation, dominant monocyte intermediate subsets and increased inflammatory subsets in PE as well as increased non-classical subsets in PE and FGR compared to normal pregnancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2018-0286","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T09:01:17Z","timestamp":1551430877000},"page":"434-438","source":"Crossref","is-referenced-by-count":14,"title":["Characterization of fetal monocytes in preeclampsia and fetal growth restriction"],"prefix":"10.1515","volume":"47","author":[{"given":"Thushari I.","family":"Alahakoon","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine, Westmead Institute of Maternal and Fetal Medicine , Westmead Hospital , Hawkesbury Road, Sydney, NSW, 2145 , Australia"},{"name":"Department of Maternal Fetal Medicine, University of Sydney , Sydney Medical School , Sydney, NSW , Australia , Tel.: +61288904852, Fax: +61288904839, Mobile: +61 414600175"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Medbury","sequence":"additional","affiliation":[{"name":"University of Sydney , Sydney Medical School , Sydney, NSW , Australia"},{"name":"Department of Surgery , Westmead Hospital , Westmead, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Sydney , Sydney Medical School , Sydney, NSW , Australia"},{"name":"Department of Surgery , Westmead Hospital , Westmead, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Fewings","sequence":"additional","affiliation":[{"name":"University of Sydney , Sydney Medical School , Sydney, NSW , Australia"},{"name":"Department of Immunology , Westmead Hospital , Westmead, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin M.","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Sydney , Sydney Medical School , Sydney, NSW , Australia"},{"name":"Scientific Platforms , Westmead Institute for Medical Research , Westmead, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W.","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Sydney , Sydney Medical School , Sydney, NSW , Australia"},{"name":"Department of Renal Medicine , Westmead Hospital , Westmead, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"2023033121263841219_j_jpm-2018-0286_ref_001_w2aab2b8c26b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, et al. 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