{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:06:49Z","timestamp":1790485609842,"version":"4.1.0"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2018-0302_s_999_w2aab3b7c34b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Earlier initiation of therapeutic hypothermia in term infants with hypoxic-ischemic encephalopathy has been shown to improve neurological outcomes. The objective of the study was to compare safety and effectiveness of servo-controlled active vs. passive cooling used during neonatal transport in achieving target core temperature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0302_s_998_w2aab3b7c34b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We undertook a prospective cohort quality improvement study with historic controls of therapeutic hypothermia during transport. Primary outcome measures were analyzed: time to cool after initiation of transport, time to achieve target temperature from birth and temperature on arrival to cooling centers. Safety was assessed by group comparison of vital signs, diagnosis of persistent pulmonary hypertension (PPHN) and coagulation profiles on arrival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0302_s_997_w2aab3b7c34b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 65 infants were included in the study. Time to cool after initiation of transport and time to achieve target temperature from birth were statistically significantly shorter in the actively cooled group with time reduction of 24% with P&lt;0.01 and 15.6% with P&lt;0.01, respectively. On arrival to our cooling center, we noted a significance difference in the mean core temperature (active 33.8\u00b0C vs. passive 35.4\u00b0C, P&lt;0.01). Seven percent (2\/30) of infants in the passively cooled group were overcooled (temperature &lt;33\u00b0C). Patients in the actively cooled group had significantly lower mean heart rate compared to the passively cooled group. There was no statistically significant difference in diagnosis of PPHN or coagulation profiles on admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0302_s_996_w2aab3b7c34b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our study indicates that active cooling with a servo-controlled device on neonatal transport is safe and more effective in achieving target temperature compared to passive cooling.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2018-0302","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T09:12:00Z","timestamp":1544173920000},"page":"365-369","source":"Crossref","is-referenced-by-count":19,"title":["Therapeutic hypothermia during neonatal transport at Regional Perinatal Centers: active vs. passive cooling"],"prefix":"10.1515","volume":"47","author":[{"given":"Rishi","family":"Lumba","sequence":"first","affiliation":[{"name":"Pediatrics, Division of Neonatology , New York University Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Mally","sequence":"additional","affiliation":[{"name":"Pediatrics, Division of Neonatology , New York University Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Espiritu","sequence":"additional","affiliation":[{"name":"Pediatrics, Division of Neonatology , New York University Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Wachtel","sequence":"additional","affiliation":[{"name":"Pediatrics, Division of Neonatology , New York University Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"2023033123573028450_j_jpm-2018-0302_ref_001_w2aab3b7c34b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edward AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;365:663\u201370.","DOI":"10.1016\/S0140-6736(05)70932-6"},{"key":"2023033123573028450_j_jpm-2018-0302_ref_002_w2aab3b7c34b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. National Institute of Child Health and Human Development Neonatal Research Network. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005;353:1574\u201384.","DOI":"10.1056\/NEJMcps050929"},{"key":"2023033123573028450_j_jpm-2018-0302_ref_003_w2aab3b7c34b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, et al. TOBY Study Group. Moderate hypothermia to treat perinatal asphyxial encephalopathy. 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