{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:58:36Z","timestamp":1773154716474,"version":"3.50.1"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2018-0420_s_999_w2aab3b7b4b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Preterm newborns may be discharged when clinical conditions are stable. Several criteria for early discharge have been proposed in the literature. This study carried out the first quantitative comparison of their impact in terms of hospitalization savings, safety and costs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0420_s_998_w2aab3b7b4b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study was based on the clinical histories of 213 premature infants born in the Neonatal Intensive Care Unit of Padova University Hospital between 2013 and 2014. Seventeen early discharge criteria were drawn from the literature and retrospectively applied to these data, and computation of hospitalization savings, safety and costs implied by each criterion was carried out.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0420_s_997_w2aab3b7b4b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the criteria considered, average gains ranged from 1.1 to 10.3 hospital days and between 0.3 and 1.1 fewer infections per discharged infant. Criteria that led to saving more hospital days had higher cost-effectiveness in terms of crisis and infection, and they spared infants from more infections. However, episodes of apnea and bradycardia were detected after the potential early discharge date for all criteria, with a mean number of episodes numbering between 0.3 and 1.4.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0420_s_996_w2aab3b7b4b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The results highlight a clear trade-off between days saved and health risks for infants, with potential consequences for health care costs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2018-0420","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T11:26:22Z","timestamp":1566041182000},"page":"885-893","source":"Crossref","is-referenced-by-count":5,"title":["Protocols for early discharging of premature infants: an empirical assessment on safety and savings"],"prefix":"10.1515","volume":"47","author":[{"given":"Chiara","family":"Daicampi","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna I.","family":"Comoretto","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health , University of Padova , Via Loredan 18 , 35121 Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Soriani","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health , University of Padova , Via Loredan 18 , 35121 Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Lolli","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Boschetto","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health , University of Padova , Via Loredan 18 , 35121 Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micol","family":"Cecchin","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health , University of Padova , Via Loredan 18 , 35121 Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Marinetto","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Pagano","sequence":"additional","affiliation":[{"name":"Unit of Cancer Epidemiology , University of Torino, CERMS and CPO-Piemonte , Torino , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egle","family":"Perissinotto","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health , University of Padova , Via Loredan 18 , 35121 Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Baraldi","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health , University of Padova , Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Gregori","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health , University of Padova , Via Loredan 18 , 35121 Padova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,8,17]]},"reference":[{"key":"2025021113482447942_j_jpm-2018-0420_ref_001_w2aab3b7b4b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Ortenstrand A, Winbladh B, Nordstr\u00f6m G, Waldenstr\u00f6m U. Early discharge of preterm infants followed by domiciliary nursing care: parents\u2019 anxiety, assessment of infant health and breastfeeding. Acta Paediatr Oslo Nor 1992 2001;90:1190\u20135.","DOI":"10.1080\/080352501317061639"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_002_w2aab3b7b4b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Lian YC, Ying SHK, Peng CC, Yann TY. Early discharge study for premature infants: Singapore General Hospital. Perm J 2008;12:15\u20138.","DOI":"10.7812\/TPP\/08-040"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_003_w2aab3b7b4b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Ahmadpour-Kacho M, Pasha YZ, Aliabadi BM. Outcomes of very-low-birthweight infants after discharge with a discharge weight of 1500 grams. Pediatr Int Off J Jpn Pediatr Soc 2012;54:196\u20139.","DOI":"10.1111\/j.1442-200X.2011.03517.x"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_004_w2aab3b7b4b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Bathie J, Shaw J. Early discharge home from the neonatal unit with the support of naso-gastric tube feeding. J Neonatal Nurs 2013;19:213\u20136.","DOI":"10.1016\/j.jnn.2013.01.005"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_005_w2aab3b7b4b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Brooten D, Kumar S, Brown LP, Butts P, Finkler SA, Bakewell-Sachs S, et al. A randomized clinical trial of early hospital discharge and home follow-up of very-low-birth-weight infants. N Engl J Med 1986;315:934\u20139.","DOI":"10.1056\/NEJM198610093151505"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_006_w2aab3b7b4b1b6b1ab2b1b6Aa","unstructured":"Casiro OG, McKenzie ME, McFadyen L, Shapiro C, Seshia MM, MacDonald N, et al. Earlier discharge with community-based intervention for low birth weight infants: a randomized trial. Pediatrics 1993;92:128\u201334."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_007_w2aab3b7b4b1b6b1ab2b1b7Aa","unstructured":"Cruz H, Guzman N, Rosales M, Bastidas J, Garcia J, Hurtado I, et al. Early hospital discharge of preterm very low birth weight infants. J Perinatol Off J Calif Perinat Assoc 1996;17:29\u201332."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_008_w2aab3b7b4b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Derbyshire F, Davies DP, Bacco A. Discharge of preterm babies from neonatal units. Br Med J Clin Res Ed 1982;284:233\u20134.","DOI":"10.1136\/bmj.284.6311.233"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_009_w2aab3b7b4b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Dillard RG, Korones SB. Lower discharge weight and shortened nursery stay for low-birth-weight infants. N Engl J Med 1973;288:131\u20133.","DOI":"10.1056\/NEJM197301182880306"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_010_w2aab3b7b4b1b6b1ab2b1c10Aa","unstructured":"Evanochko C, Jancs-Kelley S, Boyle R, Fox M, Molesky M, Byrne P. Facilitating early discharge from the NICU: the development of a home gavage program and neonatal outpatient clinic. Neonatal Netw NN 1996;15:44."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_011_w2aab3b7b4b1b6b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Kotagal UR, Perlstein PH, Gamblian V, Donovan EF, Atherton HD. Description and evaluation of a program for the early discharge of infants from a neonatal intensive care unit. J Pediatr 1995;127:285\u201390.","DOI":"10.1016\/S0022-3476(95)70312-8"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_012_w2aab3b7b4b1b6b1ab2b1c12Aa","doi-asserted-by":"crossref","unstructured":"Lefebvre F, Veilleux A, Bard H. Early discharge of low birthweight infants. Arch Dis Child 1982;57:511\u20133.","DOI":"10.1136\/adc.57.7.511"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_013_w2aab3b7b4b1b6b1ab2b1c13Aa","doi-asserted-by":"crossref","unstructured":"Merritt TA, Pillers D, Prows SL. Early NICU discharge of very low birth weight infants: a critical review and analysis. Semin Neonatol SN 2003;8:95\u2013115.","DOI":"10.1016\/S1084-2756(02)00219-1"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_014_w2aab3b7b4b1b6b1ab2b1c14Aa","doi-asserted-by":"crossref","unstructured":"\u00d6rtenstrand A, Waldenstr\u00f6m U, Winbladh B. Early discharge of preterm infants needing limited special care, followed by domiciliary nursing care. Acta Paediatr 1999;88:1024\u201330.","DOI":"10.1080\/08035259950168568"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_015_w2aab3b7b4b1b6b1ab2b1c15Aa","doi-asserted-by":"crossref","unstructured":"Rawlings JS, Scott JS. Postconceptional age of surviving preterm low-birth-weight infants at hospital discharge. Arch Pediatr Adolesc Med 1996;150:260\u20132.","DOI":"10.1001\/archpedi.1996.02170280030005"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_016_w2aab3b7b4b1b6b1ab2b1c16Aa","unstructured":"Schmidt RE, Levine DH. Early discharge of low birthweight infants as a hospital policy. J Perinatol Off J Calif Perinat Assoc 1990;10:396\u20138."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_017_w2aab3b7b4b1b6b1ab2b1c17Aa","unstructured":"Sellers L, Davidson MJ. \u201cThere\u2019s no place like home\u201d. The Neonatal Home Management Program, Carolinas HealthCare System. N C Med J 2000;61:215\u20137."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_018_w2aab3b7b4b1b6b1ab2b1c18Aa","unstructured":"Vecchi CJ, Vasquez L, Radin T, Johnson P. Neonatal individualized predictive pathway (NIPP): a discharge planning tool for parents. Neonatal Netw NN 1996;15:7\u201313."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_019_w2aab3b7b4b1b6b1ab2b1c19Aa","unstructured":"Kliegman R, Behrman RE, Nelson WE, editors. Nelson textbook of pediatrics. Edition 20. Philadelphia, PA: Elsevier; 2016."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_020_w2aab3b7b4b1b6b1ab2b1c20Aa","doi-asserted-by":"crossref","unstructured":"Knobel RB. Thermal stability of the premature infant in neonatal intensive care. Newborn Infant Nurs Rev 2014;14:72\u20136.","DOI":"10.1053\/j.nainr.2014.03.002"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_021_w2aab3b7b4b1b6b1ab2b1c21Aa","doi-asserted-by":"crossref","unstructured":"Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap) \u2013 a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009;42: 377\u201381.","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_022_w2aab3b7b4b1b6b1ab2b1c22Aa","doi-asserted-by":"crossref","unstructured":"Lambert D. Zero-inflated Poisson Regression, with an application to defects in manufacturing. Technometrics 1992;34: 1\u201314.","DOI":"10.2307\/1269547"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_023_w2aab3b7b4b1b6b1ab2b1c23Aa","doi-asserted-by":"crossref","unstructured":"You JHS, Chan CY, Wong MY, Ip M. Active surveillance and decolonization of methicillin-resistant Staphylococcus aureus on admission to neonatal intensive care units in Hong Kong: a cost-effectiveness analysis. Infect Control Hosp Epidemiol 2012;33:1024\u201330.","DOI":"10.1086\/667735"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_024_w2aab3b7b4b1b6b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Vijgen SMC, van der Ham DP, Bijlenga D, van Beek JJ, Bloemenkamp KWM, Kwee A, et al. Economic analysis comparing induction of labor and expectant management in women with preterm prelabor rupture of membranes between 34 and 37 weeks (PPROMEXIL trial). Acta Obstet Gynecol Scand 2014;93:374\u201381.","DOI":"10.1111\/aogs.12329"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_025_w2aab3b7b4b1b6b1ab2b1c25Aa","unstructured":"R Development Core Team. R: A language and environment for statistical computing. [Internet]. R Foundation for Statistical Computing, Vienna, Austria; 2009. Available from: http:\/\/www.R-project.org. Accessed October 29, 2018."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_026_w2aab3b7b4b1b6b1ab2b1c26Aa","doi-asserted-by":"crossref","unstructured":"Harrell FE. Regression modeling strategies: with applications to linear models, logistic regression, and survival analysis. Second edition. New York: Springer; 2015.","DOI":"10.1007\/978-3-319-19425-7"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_027_w2aab3b7b4b1b6b1ab2b1c27Aa","unstructured":"Leisch F. Bootstrap: Functions for the Book \u201cAn Introduction to the Bootstrap\u201d [Internet]. United States Studies Centre, University of Sydney; 2014. Available from: https:\/\/github.com\/cran\/bootstrap. Accessed October 29, 2018."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_028_w2aab3b7b4b1b6b1ab2b1c28Aa","unstructured":"Jackman S. pscl: Classes and Methods for R Developed in the Political Science Computational Laboratory [Internet]. Sydney, New South Wales, Australia: United States Studies Centre, University of Sydney; 2014. Available from: https:\/\/github.com\/atahk\/pscl. Accessed October 29, 2018."},{"key":"2025021113482447942_j_jpm-2018-0420_ref_029_w2aab3b7b4b1b6b1ab2b1c29Aa","doi-asserted-by":"crossref","unstructured":"Collins CT, Makrides M, McPhee AJ. Early discharge with home support of gavage feeding for stable preterm infants who have not established full oral feeds. Cochrane Database Syst Rev 2003:CD003743. DOI: 10.1002\/14651858.CD003743.","DOI":"10.1002\/14651858.CD003743"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_030_w2aab3b7b4b1b6b1ab2b1c30Aa","doi-asserted-by":"crossref","unstructured":"D Evans I. Tubefeeding newborn babies at home. J R Army Med Corps 1988;134:149\u201350.","DOI":"10.1136\/jramc-134-03-09"},{"key":"2025021113482447942_j_jpm-2018-0420_ref_031_w2aab3b7b4b1b6b1ab2b1c31Aa","unstructured":"Swanson SC, Naber MM. Neonatal integrated home care: nursing without walls. Neonatal Netw NN 1997;16:33\u20138."}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpme.2019.47.issue-8\/jpm-2018-0420\/jpm-2018-0420.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2018-0420\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2018-0420\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T13:48:49Z","timestamp":1739281729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2018-0420\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,17]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,17]]},"published-print":{"date-parts":[[2019,10,25]]}},"alternative-id":["10.1515\/jpm-2018-0420"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2018-0420","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8,17]]}}}