{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:34:26Z","timestamp":1740141266699,"version":"3.37.3"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"j_jpm-2018-0428_s_999\">\n<jats:title id=\"d11421495e11710\">Background<\/jats:title>\n<jats:p>The association between bacteriuria and adverse pregnancy outcomes has been extensively described. The current practice of screening all pregnant women for bacteriuria is challenged by recent studies. We aimed to evaluate pregnancy outcomes among women with a positive urine culture, to assess the significance of positive urinary nitrites in this setting.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpm-2018-0428_s_998\">\n<jats:title id=\"d11421495e11718\">Methods<\/jats:title>\n<jats:p>This was a retrospective cohort study at the emergency department (ED) of the Helen Schneider Hospital for Women, Israel, during 2014\u20132018. This included all gravida women &gt;18 years old within the 20<jats:sup>th<\/jats:sup> week of pregnancy or above, admitted to the ED with diverse complains, who had urinalysis collected and subsequently had a positive urine culture. Clinical and obstetric characteristics were stratified by positive vs. negative nitrites in urinalysis. The primary outcome was premature delivery, and the secondary outcomes were a composite outcome of all recorded pregnancy complications and the significance of urinalysis in predicting urinary tract infection (UTI).<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpm-2018-0428_s_997\">\n<jats:title id=\"d11421495e11729\">Results<\/jats:title>\n<jats:p>Overall, 874 pregnant women with a positive urine culture were included. Of them, 721 (79%) patients had a negative nitrite in their urine exam (NNU-group) and 153 (21%) had a positive nitrite in their urine exam (PNU-group). <jats:italic>Escherichia coli<\/jats:italic> was the most common pathogen, with significantly higher rates of growth in the PNU-group vs. NNU-group [129 (84.3%) vs. 227 (38.4%), P &lt; 0.001]. Premature delivery was recorded with no association of symptomaticity or nitrite status. Among symptomatic women with classic symptoms of UTI, PNU was significantly associated with decreased risk for major peripartum complications [odds ratio (OR) with 95% confidence interval (CI) of 0.22 (0.05\u20130.94)].<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpm-2018-0428_s_996\">\n<jats:title id=\"d11421495e11740\">Conclusion<\/jats:title>\n<jats:p>Our findings support that PNU among symptomatic pregnant women with UTI-related symptoms was associated with lower risk of developing major adverse obstetrical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2018-0428","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T09:03:03Z","timestamp":1559120583000},"page":"611-618","source":"Crossref","is-referenced-by-count":4,"title":["Pregnancy outcome following bacteriuria in pregnancy and the significance of nitrites in urinalysis \u2013 a retrospective cohort study"],"prefix":"10.1515","volume":"47","author":[{"given":"Eviatar","family":"Naamany","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Ayalon-Dangur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3101-2827","authenticated-orcid":false,"given":"Eran","family":"Hadar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iftach","family":"Sagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafna","family":"Yahav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-0075","authenticated-orcid":false,"given":"Shachaf","family":"Shiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref441","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting","volume":"36","year":"2008","journal-title":"Am J Infect Control"},{"key":"ref61","first-page":"CD000490","article-title":"Antibiotics for asymptomatic bacteriuria in pregnancy","volume":"8","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s12884-016-1128-0","article-title":"Benefits and harms of screening for and treatment of asymptomatic bacteriuria in pregnancy: a systematic review","volume":"16","year":"2016","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref301","first-page":"CD000490","article-title":"Antibiotics for asymptomatic bacteriuria in pregnancy","volume":"8","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1186\/1756-0500-7-481","article-title":"Diagnostic accuracy of rapid urine dipstick test to predict urinary tract infection among pregnant women in Felege Hiwot Referral Hospital, Bahir Dar, North West Ethiopia","volume":"7","year":"2014","journal-title":"BMC Res Notes"},{"key":"ref371","first-page":"89","article-title":"Asymptomatic bacteriuria among an obstetric population in Ibadan","volume":"30","year":"2011","journal-title":"West Afr J Med"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s12884-016-1128-0","article-title":"Benefits and harms of screening for and treatment of asymptomatic bacteriuria in pregnancy: a systematic review","volume":"16","year":"2016","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1186\/1756-0500-7-481","article-title":"Diagnostic accuracy of rapid urine dipstick test to predict urinary tract infection among pregnant women in Felege Hiwot Referral Hospital, Bahir Dar, North West Ethiopia","volume":"7","year":"2014","journal-title":"BMC Res Notes"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting","volume":"36","year":"2008","journal-title":"Am J Infect Control"},{"key":"ref211","first-page":"129","article-title":"Urinary tract infections in patients with type 2 diabetes mellitus: review of prevalence, diagnosis, and management","volume":"8","year":"2015","journal-title":"Diabetes Metab Syndr Obes"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4103\/2249-4863.154672","article-title":"Reliability of dipstick assay in predicting urinary tract infection","volume":"4","year":"2015","journal-title":"J Family Med Prim Care"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S1473-3099(15)00070-5","article-title":"Maternal and neonatal consequences of treated and untreated asymptomatic bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial","volume":"15","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"ref01","first-page":"1556","article-title":"Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults","volume":"40","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0378-3782(79)90031-8","article-title":"The duration of maternal cigarette smoking, fetal and placental disorders","volume":"3","year":"1979","journal-title":"Early Hum Dev"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"W20","DOI":"10.7326\/0003-4819-149-1-200807010-00009-w1","article-title":"Screening for asymptomatic bacteriuria in adults: evidence for the U.S. Preventive Services Task Force reaffirmation recommendation statement","volume":"149","year":"2008","journal-title":"Ann Intern Med"},{"key":"ref121","first-page":"488","article-title":"Urine test to diagnose urinary tract infection in high-risk pregnant women","volume":"34","year":"2012","journal-title":"Rev Bras Ginecol Obstet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0378-3782(79)90031-8","article-title":"The duration of maternal cigarette smoking, fetal and placental disorders","volume":"3","year":"1979","journal-title":"Early Hum Dev"},{"key":"ref131","first-page":"89","article-title":"Asymptomatic bacteriuria among an obstetric population in Ibadan","volume":"30","year":"2011","journal-title":"West Afr J Med"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/AOG.0b013e31827e8cfe","article-title":"Contamination rates of three urine-sampling methods to assess bacteriuria in pregnant women","volume":"121","year":"2013","journal-title":"Obstet Gynecol"},{"key":"ref141","first-page":"339","article-title":"Reliability of urine multistix and Gram stain in the detection of asymptomatic bacteriuria in pregnancy","volume":"29","year":"2010","journal-title":"West Afr J Med"},{"key":"ref381","first-page":"339","article-title":"Reliability of urine multistix and Gram stain in the detection of asymptomatic bacteriuria in pregnancy","volume":"29","year":"2010","journal-title":"West Afr J Med"},{"key":"ref11","first-page":"439","article-title":"Asymptomatic bacteriuria in pregnancy","volume":"2","year":"2007","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref41","first-page":"41","article-title":"Uterine contraction frequency during treatment of pyelonephritis in pregnancy and subsequent risk of preterm birth","volume":"31","year":"2003","journal-title":"J Perinat Med"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1186\/1756-0500-7-481","article-title":"Diagnostic accuracy of rapid urine dipstick test to predict urinary tract infection among pregnant women in Felege Hiwot Referral Hospital, Bahir Dar, North West Ethiopia","volume":"7","year":"2014","journal-title":"BMC Res Notes"},{"key":"ref251","first-page":"439","article-title":"Asymptomatic bacteriuria in pregnancy","volume":"2","year":"2007","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2362.2008.02009.x","article-title":"Asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy","volume":"38","year":"2008","journal-title":"Eur J Clin Invest"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/01443610802196914","article-title":"The diagnostic accuracy of the rapid dipstick test to predict asymptomatic urinary tract infection of pregnancy","volume":"28","year":"2008","journal-title":"J Obstet Gynaecol"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/AOG.0b013e31827e8cfe","article-title":"Contamination rates of three urine-sampling methods to assess bacteriuria in pregnant women","volume":"121","year":"2013","journal-title":"Obstet Gynecol"},{"key":"ref241","first-page":"1556","article-title":"Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults","volume":"40","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref361","first-page":"488","article-title":"Urine test to diagnose urinary tract infection in high-risk pregnant women","volume":"34","year":"2012","journal-title":"Rev Bras Ginecol Obstet"},{"key":"ref281","first-page":"41","article-title":"Uterine contraction frequency during treatment of pyelonephritis in pregnancy and subsequent risk of preterm birth","volume":"31","year":"2003","journal-title":"J Perinat Med"},{"key":"ref51","first-page":"576","article-title":"Meta-analysis of the relationship between asymptomatic bacteriuria and preterm delivery\/low birth weight","volume":"73","year":"1989","journal-title":"Obstet Gynecol"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S1473-3099(15)00070-5","article-title":"Maternal and neonatal consequences of treated and untreated asymptomatic bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial","volume":"15","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"W20","DOI":"10.7326\/0003-4819-149-1-200807010-00009-w1","article-title":"Screening for asymptomatic bacteriuria in adults: evidence for the U.S. Preventive Services Task Force reaffirmation recommendation statement","volume":"149","year":"2008","journal-title":"Ann Intern Med"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2490-4-4","article-title":"The urine dipstick test useful to rule out infections. A meta-analysis of the accuracy","volume":"4","year":"2004","journal-title":"BMC Urol"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/01443610802196914","article-title":"The diagnostic accuracy of the rapid dipstick test to predict asymptomatic urinary tract infection of pregnancy","volume":"28","year":"2008","journal-title":"J Obstet Gynaecol"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1056\/NEJMoa1302186","article-title":"Voided midstream urine culture and acute cystitis in premenopausal women","volume":"369","year":"2013","journal-title":"N Engl J Med"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajog.2017.12.231","article-title":"Diagnosis and treatment of urinary tract infections across age groups","volume":"219","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2490-4-4","article-title":"The urine dipstick test useful to rule out infections. A meta-analysis of the accuracy","volume":"4","year":"2004","journal-title":"BMC Urol"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4103\/2249-4863.154672","article-title":"Reliability of dipstick assay in predicting urinary tract infection","volume":"4","year":"2015","journal-title":"J Family Med Prim Care"},{"key":"ref291","first-page":"576","article-title":"Meta-analysis of the relationship between asymptomatic bacteriuria and preterm delivery\/low birth weight","volume":"73","year":"1989","journal-title":"Obstet Gynecol"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1186\/1756-0500-7-481","article-title":"Diagnostic accuracy of rapid urine dipstick test to predict urinary tract infection among pregnant women in Felege Hiwot Referral Hospital, Bahir Dar, North West Ethiopia","volume":"7","year":"2014","journal-title":"BMC Res Notes"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajog.2017.12.231","article-title":"Diagnosis and treatment of urinary tract infections across age groups","volume":"219","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2362.2008.02009.x","article-title":"Asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy","volume":"38","year":"2008","journal-title":"Eur J Clin Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0891-5520(05)70339-1","article-title":"Urinary tract infections complicating pregnancy","volume":"11","year":"1997","journal-title":"Infect Dis Clin North Am"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1056\/NEJMoa1302186","article-title":"Voided midstream urine culture and acute cystitis in premenopausal women","volume":"369","year":"2013","journal-title":"N Engl J Med"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0891-5520(05)70339-1","article-title":"Urinary tract infections complicating pregnancy","volume":"11","year":"1997","journal-title":"Infect Dis Clin North Am"},{"key":"ref451","first-page":"129","article-title":"Urinary tract infections in patients with type 2 diabetes mellitus: review of prevalence, diagnosis, and management","volume":"8","year":"2015","journal-title":"Diabetes Metab Syndr Obes"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpme.2019.47.issue-6\/jpm-2018-0428\/jpm-2018-0428.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2018-0428\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:36:16Z","timestamp":1619055376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2018-0428\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,27]]},"references-count":48,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1515\/jpm-2018-0428","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"type":"electronic","value":"1619-3997"},{"type":"print","value":"0300-5577"}],"subject":[],"published":{"date-parts":[[2019,8,27]]}}}