{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:55:45Z","timestamp":1782755745737,"version":"3.54.5"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2019-0019_s_999_w2aab3b7c13b1b6b1aab1c15b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) are used as markers of preeclampsia. The aim of this paper was to assess the correlations between the sFlt-1\/PlGF ratio values within the &lt;38, 38\u201385 and &gt;85 brackets and perinatal outcomes in pregnancies that require determination of these markers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0019_s_998_w2aab3b7c13b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 927 pregnant patients between 18 and 41 weeks\u2019 gestation suspected of or confirmed with any form of placental insufficiency (preeclampsia, intrauterine growth restriction [IUGR], gestational hypertension, HELLP syndrome, placental abruption) were included in the study. In each of the patients, the sFlt-1\/PlGF ratio was calculated. Patients were divided into three groups according to the sFlt-1\/PlGF ratio brackets of &lt;38, 38\u201385 and &gt;85.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0019_s_997_w2aab3b7c13b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Significantly worse perinatal outcomes were found in the sFlt-1\/PlGF &gt;85 group, primarily with lower cord blood pH, neonatal birth weight and shorter duration of gestation. Statistically significant correlations between the values of these markers and the abovementioned perinatal effects were found.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0019_s_996_w2aab3b7c13b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>An sFlt-1\/PlGF ratio value of &gt;85 suggests that either preeclampsia or one of the other placental insufficiency forms may occur, which is associated with lower cord blood pH, newborn weight and earlier delivery. Determining the disordered angiogenesis markers and calculating the sFlt-1\/PlGF ratio in pregnancies complicated by placental insufficiency may lead to better diagnosis, therapeutic decisions and better perinatal outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2019-0019","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T17:02:55Z","timestamp":1563987775000},"page":"732-740","source":"Crossref","is-referenced-by-count":25,"title":["The sFlt-1\/PlGF ratio values within the &lt;38, 38\u201385 and &gt;85 brackets as compared to perinatal outcomes"],"prefix":"10.1515","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-7774","authenticated-orcid":false,"given":"Magdalena","family":"Bednarek-J\u0119drzejek","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics , Pomeranian Medical University , Clinical Hospital nr 2, Powstancow Wielkopolskich 72 , 70-111 Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Ksel-Hryci\u00f3w","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Tousty","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Nurek","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Kwiatkowska","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Medicine , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Cymbaluk-P\u0142oska","sequence":"additional","affiliation":[{"name":"Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Torb\u00e9","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Pomeranian Medical University , Szczecin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"2023033123583578699_j_jpm-2019-0019_ref_001_w2aab3b7c13b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Maynard SE, Karumanchi SA. 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