{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:10:13Z","timestamp":1782367813038,"version":"3.54.5"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"j_jpm-2019-0034_s_999\">\n<jats:title id=\"d11421495e25560\">Background<\/jats:title>\n<jats:p>Sj\u00f6gren\u2019s syndrome (SS) is an autoimmune connective tissue disease affecting the body\u2019s moisture-producing glands. Some studies have linked SS to adverse maternal\/neonatal outcomes, but sample sizes have tended to be small, with few outcomes examined. The purpose of this study was to evaluate the effect of SS on pregnancy outcomes for mother and neonate using a large dataset.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpm-2019-0034_s_998\">\n<jats:title id=\"d11421495e25568\">Methods<\/jats:title>\n<jats:p>We carried out a retrospective cohort study of women who delivered between 1999 and 2014 using data from the Nationwide Inpatient Sample from the United States. SS categorization is based on ICD-9 coding. Baseline characteristics were compared in both groups and multivariate logistic regression was used to compare maternal and fetal outcomes of pregnancies in women with and without SS.<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpm-2019-0034_s_997\">\n<jats:title id=\"d11421495e25576\">Results<\/jats:title>\n<jats:p>The prevalence of SS in our population was 1.34 cases\/10,000 births, with the rate increasing over the study period. Women with SS tended to be older, Caucasian and to have pre-existing comorbidities. Births to women with SS were at greater risk of pre-eclampsia [odds ratio (OR) 1.63, 95% confidence interval (CI) 1.34\u20131.99]; premature rupture of membranes (OR 1.28, 95% CI 1.04\u20131.57); preterm delivery (OR 1.56, 95% CI 1.34\u20131.81); cesarean delivery (OR 1.29, 95% CI 1.17\u20131.41); and venous thromboembolic events (OR 3.71, 95% CI 2.57\u20135.35). Infants of women with SS were more likely to have intrauterine growth restriction (IUGR) (OR 3.00, 95% CI 2.46\u20133.65); and congenital malformations (OR 3.26, 95% CI 2.30\u20134.62).<\/jats:p><\/jats:sec>\n<jats:sec id=\"j_jpm-2019-0034_s_996\">\n<jats:title id=\"d11421495e25584\">Conclusion<\/jats:title>\n<jats:p>SS is a high-risk pregnancy condition associated with significant comorbidities and adverse maternal and fetal outcomes. Women with SS may benefit from increased surveillance during their pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2019-0034","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T09:03:53Z","timestamp":1562663033000},"page":"637-642","source":"Crossref","is-referenced-by-count":26,"title":["Effect of Sj\u00f6gren\u2019s syndrome on maternal and neonatal outcomes of pregnancy"],"prefix":"10.1515","volume":"47","author":[{"given":"Brittney","family":"Elliott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R.","family":"Spence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Czuzoj-Shulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim Arie","family":"Abenhaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref131","first-page":"65","article-title":"Fetal outcome in women with primary Sj\u00f6gren\u2019s syndrome. 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