{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T22:29:43Z","timestamp":1768775383165,"version":"3.49.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2019-0040_s_999_w2aab3b7c20b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Bisphenol A (BPA) is an estrogenic, endocrine-disrupting compound widely used in the industry. It is also a ubiquitous environmental pollutant. Its presence was confirmed in human fetuses, which results from maternal exposure during pregnancy. The mechanisms behind maternal-fetal transfer, and relationships between pregnant women and fetal exposures remain unclear. The aim of this study was to assess the impact of maternal exposure to BPA on the exposure of the fetus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0040_s_998_w2aab3b7c20b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Maternal plasma and amniotic fluid samples were collected from 52 pregnant women undergoing amniocentesis for prenatal diagnosis of chromosomal abnormalities. BPA was measured by gas chromatography-mass spectrometry (GC-MS). The permeability factor \u2013 a ratio of fetal-to-maternal BPA concentration \u2013 was used as a measure delineating the transplacental transfer of BPA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0040_s_997_w2aab3b7c20b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median concentration of maternal plasma BPA was 8 times higher than the total BPA concentration in the amniotic fluid (8.69 ng\/mL, range: 4.3 ng\/mL\u201355.3 ng\/mL vs. median 1.03 ng\/mL, range: 0.3 ng\/mL\u201310.1 ng\/mL). There was no direct relationship between the levels of BPA in maternal plasma and amniotic fluid levels. The permeability factor, in turn, negatively correlated with fetal development (birth weight) (R\u2009=\u2009\u22120.54, P\u2009&lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0040_s_996_w2aab3b7c20b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results suggest that the risk of fetal BPA exposure depends on placental BPA permeability rather than the levels of maternal BPA plasma concentration and support general recommendations to become aware and avoid BPA-containing products.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2019-0040","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T09:02:37Z","timestamp":1564131757000},"page":"765-770","source":"Crossref","is-referenced-by-count":26,"title":["Simultaneous analysis of bisphenol A fractions in maternal and fetal compartments in early second trimester of pregnancy"],"prefix":"10.1515","volume":"47","author":[{"given":"Monika","family":"Zbucka-Kr\u0119towska","sequence":"first","affiliation":[{"name":"Department of Reproduction and Gynaecological Endocrinology , Medical University of Bialystok , Marii Sklodowskiej-Curie 24a , 15-276 Bialystok , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"\u0141azarek","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis , Medical University of Bialystok , Mickiewicza 2D , 15-522 Bialystok , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Miltyk","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis , Medical University of Bialystok , Mickiewicza 2D , 15-522 Bialystok , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0254-3095","authenticated-orcid":false,"given":"Iwona","family":"Sidorkiewicz","sequence":"additional","affiliation":[{"name":"Clinical Research Centre , Medical University of Bialystok , Marii Sklodowskiej-Curie 24a , 15-276 Bialystok , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Pierzy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Gynaecological Endocrinology , Medical University of Bialystok , Marii Sklodowskiej-Curie 24a , 15-276 Bialystok , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Milewski","sequence":"additional","affiliation":[{"name":"Department of Statistics and Medical Informatics , Medical University of Bialystok , Szpitalna 37 , 15-295 Bialystok , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomir","family":"Wo\u0142czy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Gynaecological Endocrinology , Medical University of Bialystok , Marii Sklodowskiej-Curie 24a , 15-276 Bialystok , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Czerniecki","sequence":"additional","affiliation":[{"name":"Department of Biology and Pathology of Human Reproduction , Institute of Animal Reproduction and Food Research, Polish Academy of Science , Tuwima 10 , 10-748 Olsztyn , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"2023033123583581388_j_jpm-2019-0040_ref_001_w2aab3b7c20b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Rochester JR. 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