{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:12:28Z","timestamp":1792073548350,"version":"4.4.0"},"reference-count":50,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2019-0116_s_999\"><jats:title id=\"d11421495e45864\">Background<\/jats:title><jats:p>Whether placental location confers specific neonatal risks is controversial. In particular, whether placenta previa is associated with intra-uterine growth restriction (IUGR)\/small for gestational age (SGA) remains a matter of debate.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2019-0116_s_998\"><jats:title id=\"d11421495e45872\">Methods<\/jats:title><jats:p>We searched Medline, EMBASE, Google Scholar, Scopus, ISI Web of Science and Cochrane database search, as well as PubMed (www.pubmed.gov) until the end of December 2018 to conduct a systematic review and meta-analysis to determine the risk of IUGR\/SGA in cases of placenta previa. We defined IUGR\/SGA as birth weight below the 10<jats:sup>th<\/jats:sup>percentile, regardless of the terminology used in individual studies. Risk of bias was assessed using the Cochrane Handbook for Systematic Reviews of Interventions. We used odds ratios (OR) and a fixed effects (FE) model to calculate weighted estimates in a forest plot. Statistical homogeneity was checked with the I<jats:sup>2<\/jats:sup>statistic using Review Manager 5.3.5 (The Cochrane Collaboration, 2014).<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2019-0116_s_997\"><jats:title id=\"d11421495e45886\">Results<\/jats:title><jats:p>We obtained 357 records, of which 13 met the inclusion criteria. All study designs were retrospective in nature, and included 11 cohort and two case-control studies. A total of 1,593,226 singleton pregnancies were included, of which 10,575 had a placenta previa. The incidence of growth abnormalities was 8.7\/100 births in cases of placenta previa vs. 5.8\/100 births among controls. Relative to cases with alternative placental location, pregnancies with placenta previa were associated with a mild increase in the risk of IUGR\/SGA, with a pooled OR [95% confidence interval (CI)] of 1.19 (1.10\u20131.27). Statistical heterogeneity was high with an I<jats:sup>2<\/jats:sup>\u2009=\u200994%.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2019-0116_s_996\"><jats:title id=\"d11421495e45897\">Conclusion<\/jats:title><jats:p>Neonates from pregnancies with placenta previa have a mild increase in the risk of IUGR\/SGA.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2019-0116","type":"journal-article","created":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T05:58:48Z","timestamp":1563083928000},"page":"577-584","source":"Crossref","is-referenced-by-count":35,"title":["Placenta previa and the risk of intrauterine growth restriction (IUGR): a systematic review and meta-analysis"],"prefix":"10.1515","volume":"47","author":[{"given":"Jacques","family":"Balayla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Desilets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Shrem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref91","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1600-0412.2012.01375.x","article-title":"A Danish national cohort study on neonatal outcome in singleton pregnancies with placenta previa","volume":"91","year":"2012","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/01.AOG.0000207559.15715.98","article-title":"Placenta previa, placenta accreta, and vasa previa","volume":"107","year":"2006","journal-title":"Obstet 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