{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:03:43Z","timestamp":1791644623768,"version":"4.3.4"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2019-0217_s_999_w2aab3b7c68b1b6b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Altered cardiac geometry affects a proportion of fetuses with growth restriction (FGR). The aim of this study was to explore the hemodynamic factors associated with cardiac remodeling in late FGR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0217_s_998_w2aab3b7c68b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a prospective study of singleton pregnancies complicated by late-onset FGR undergoing assessment of left (LV) and right (RV) ventricular sphericity-index (SI). The study population was divided in two groups according to the presence of cardiac remodelling, defined as LVSI &lt;5<jats:sup>th<\/jats:sup> centile. The following outcomes were explored: gestational age at birth, birthweight, caesarean section (CS) for fetal distress, umbilical artery (UA) pH and neonatal admission to special care unit. The differences between the 2 groups in UA pulsatility index (PI), middle cerebral artery (MCA) PI, uterine artery PI, cerebroplacental ratio (CPR) and umbilical vein (UV) flow corrected for fetal abdominal circumference (UVBF\/AC) were tested.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0217_s_997_w2aab3b7c68b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 212 pregnancies with late FGR were enrolled in the study. An abnormal LV SI was detected in 119 fetuses (56.1%). Late FGR fetuses with cardiac remodeling had a lower birthweight (2390 g vs. 2490; P = 0.04) and umbilical artery pH (7.21 vs. 7.24; P = 0.04) and were more likely to have emergency CS (42.8% vs. 26.9%; P = 0.023) and admission to special care unit (13.4% vs. 4.3%; P = 0.03) compared to those with normal LVSI. No difference in either UA PI (p = 0.904), MCA PI (P = 0.575), CPR (P = 0.607) and mean uterine artery PI (P = 0.756) were present between fetuses with or without an abnormal LV SI. Conversely, UVBF\/AC z-score was lower (\u22121.84 vs. \u22120.99; P \u2264 0.001) in fetuses with cardiac remodeling and correlated with LV (P \u2264 0.01) and RV SI (P \u2264 0.02).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0217_s_996_w2aab3b7c68b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Fetal cardiac remodelling occurs in a significant proportion of pregnancies complicated by late FGR and is affected by a high burden of short-term perinatal compromise. The occurrence of LV SI is independent from fetal arterial Dopplers while it is positively associated with umbilical vein blood flow.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2019-0217","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T09:02:15Z","timestamp":1564045335000},"page":"683-688","source":"Crossref","is-referenced-by-count":45,"title":["Hemodynamic factors associated with fetal cardiac remodeling in late fetal growth restriction: a prospective study"],"prefix":"10.1515","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-4353","authenticated-orcid":false,"given":"Giuseppe","family":"Rizzo","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine , Universit\u00e0 di Roma Tor Vergata , Ospedale Cristo Re , Roma , Italy"},{"name":"Department of Obstetrics and Gynecology , The First I.M. Sechenov Moscow State Medical University , Moscow , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine , Universit\u00e0 di Roma Tor Vergata , Ospedale Cristo Re , Roma , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Mappa","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine , Universit\u00e0 di Roma Tor Vergata , Ospedale Cristo Re , Roma , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Bitsadze","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine , Universit\u00e0 di Roma Tor Vergata , Ospedale Cristo Re , Roma , Italy"},{"name":"Department of Obstetrics and Gynecology , The First I.M. Sechenov Moscow State Medical University , Moscow , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamilya","family":"Khizroeva","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine , Universit\u00e0 di Roma Tor Vergata , Ospedale Cristo Re , Roma , Italy"},{"name":"Department of Obstetrics and Gynecology , The First I.M. Sechenov Moscow State Medical University , Moscow , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"S\u0142odki","sequence":"additional","affiliation":[{"name":"Department of Prenatal Cardiology , Polish Mother\u2019s Memorial Hospital Research Institute , Lodz , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Makatsarya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , The First I.M. Sechenov Moscow State Medical University , Moscow , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Foggia , Foggia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"2023033123583580038_j_jpm-2019-0217_ref_001_w2aab3b7c68b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Crispi F, Miranda J, Gratac\u00f3s E. Long-term cardiovascular consequences of fetal growth restriction: biology, clinical implications, and opportunities for prevention of adult disease. 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