{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:49:38Z","timestamp":1747198178498,"version":"3.40.5"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2019-0228_s_999_w2aab3b7c16b1b6b1aab1c17b1Aa\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To explore the risk for abnormal chromosomal microarray analysis (CMA) findings in pregnancies with oligohydramnios.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0228_s_998_w2aab3b7c16b1b6b1aab1c17b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from all CMA analyses performed due to oligohydramnios between 2013 and 2017 were retrospectively obtained from the Israeli Ministry of Health database. The rate of clinically significant (pathogenic and likely pathogenic) findings was compared to a local cohort of pregnancies with normal ultrasound, yielding a 1.4% rate of abnormal CMA results. In addition, a search was conducted through the PubMed database addressing the issue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0228_s_997_w2aab3b7c16b1b6b1aab1c17b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty CMA analyses were performed due to oligohydramnios. The 2% risk for clinically significant CMA finding in pregnancies with oligohydramnios did not differ from the control population of 5541 pregnancies with normal ultrasound \u2013 relative risk (RR) 1.4 [95% confidence interval (CI) 0.2\u201310.2]. Literature search yielded 394 titles, of which four relevant articles were selected, all using fetal karyotyping.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0228_s_996_w2aab3b7c16b1b6b1aab1c17b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There is yet insufficient evidence to support invasive prenatal testing in pregnancies with isolated oligohydramnios.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2019-0228","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T12:32:01Z","timestamp":1575721921000},"page":"53-58","source":"Crossref","is-referenced-by-count":6,"title":["Microarray findings in pregnancies with oligohydramnios \u2013 a retrospective cohort study and literature review"],"prefix":"10.1515","volume":"48","author":[{"given":"Amihood","family":"Singer","sequence":"first","affiliation":[{"name":"Community Genetics, Public Health Services, Ministry of Health , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idit","family":"Maya","sequence":"additional","affiliation":[{"name":"Recanati Genetics Institute, Beilinson Hospital, Rabin Medical Center , Petach Tikva , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivka","family":"Sukenik-Halevy","sequence":"additional","affiliation":[{"name":"Recanati Genetics Institute, Beilinson Hospital, Rabin Medical Center , Petach Tikva , Israel"},{"name":"Sackler School of Medicine , Tel Aviv University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Tenne","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute , Meir Medical Center , Kfar Sava , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Lev","sequence":"additional","affiliation":[{"name":"The Rina Mor Institute of Medical Genetics , Wolfson Medical Center , Holon , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shay","family":"Ben Shachar","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine , Tel Aviv University , Tel Aviv , Israel"},{"name":"The Genetic Institute , Tel-Aviv Sourasky Medical Center , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-2130","authenticated-orcid":false,"given":"Lena","family":"Sagi-Dain","sequence":"additional","affiliation":[{"name":"Genetics Institute, Carmel Medical Center, Affiliated to the Ruth and Bruce Rappaport Faculty of Medicine, Technion \u2013 Israel Institute of Technology , Haifa , Israel"},{"name":"Genetics Institute, Department of Obstetrics and Gynecology , Carmel Medical Center , 7 Michal St. , Haifa , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,12,7]]},"reference":[{"key":"2023040100004387699_j_jpm-2019-0228_ref_001_w2aab3b7c16b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Locatelli A, Zagarella A, Toso L, Assi F, Ghidini A, Biffi A. 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