{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:01:05Z","timestamp":1763535665004,"version":"3.40.5"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2019-0261_s_999_w2aab3b7c26b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To select a group at high risk of placenta accreta spectrum disorders (PAS) based on the data of serum screening in the first trimester.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0261_s_998_w2aab3b7c26b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective analysis of 48 patients with abnormal placental location (AP), including placenta previa (PP) only (n\u2009=\u200923) and PP and PAS (n\u2009=\u200925), was performed. Additionally, the AP group was divided depending on the blood loss volume: not higher than 1000 mL (LBL) (n\u2009=\u200929) and higher than 1000 mL (HBL) (n\u2009=\u200919); diagnostic term of PAS by ultrasound, data pregnancy-associated plasma protein-A (\u0420A\u0420\u0420-A) and free \u03b2 subunit of human chorionic gonadotropin (free \u03b2-hCG) multiple of median (M\u043eM) at 11<jats:sup>+0<\/jats:sup>\u201313<jats:sup>+6<\/jats:sup> weeks of gestation were evaluated. Serological markers were compared with the data of 39 healthy pregnant women with scar after previous cesarean section and normal placental location (control).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0261_s_997_w2aab3b7c26b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean gestation at diagnostic term of PAS was 29 weeks. PAPP-\u0420 M\u043eM [mean (M)\u2009\u00b1\u2009standard deviation (SD)] was: in controls, 1.07\u2009\u00b1\u20090.47; in the AP group, 1.59\u2009\u00b1\u20090.24; in PP, 1.91\u2009\u00b1\u20091.52; in PAS, 1.30\u2009\u00b1\u20090.85; in LBL, 1.37\u2009\u00b1\u20091.20; in HBL, 1.91\u2009\u00b1\u20091.24. The difference between control\/AP, control\/PP, control\/PAS, PP\/PAS, control\/LBL, control\/HBL and LBL\/HBL was \u0420\u2009=\u20090.256, 0.145, 0.640, 0.311, 0.954, 0.025 and 0.09, respectively. Free \u03b2-hCG MoM (M\u2009\u00b1\u2009SD) was: in controls, 1.08\u2009\u00b1\u20090.69, in AP, 1.31\u2009\u00b1\u20090.96; in PP, 1.46\u2009\u00b1\u20090.19; in PAS, 1.16\u2009\u00b1\u20090.65; in LBL, 1.30\u2009\u00b1\u20090.06; in HBL, 1.32\u2009\u00b1\u20090.78. Comparison of free \u03b2-hCG AP with controls and between subgroups did not reveal a significant difference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2019-0261_s_996_w2aab3b7c26b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Underestimation of PAS risk factors in pregnant women with AP leads to late diagnostics of pathology only in the third trimester. The assessment of the \u0420A\u0420\u0420-A level in the first trimester may be helpful for the early prognosis of pathological blood loss at delivery for pregnant women with AP and for forming the high-risk group for PAS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2019-0261","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T16:29:50Z","timestamp":1573748990000},"page":"21-26","source":"Crossref","is-referenced-by-count":15,"title":["Significance of the routine first-trimester antenatal screening program for aneuploidy in the assessment of the risk of placenta accreta spectrum disorders"],"prefix":"10.1515","volume":"48","author":[{"given":"Grigory A.","family":"Penzhoyan","sequence":"first","affiliation":[{"name":"Federal State Budgetary Educational Institution of Higher Education , \u201cKuban State Medical University\u201d of the Ministry of Healthcare of the Russian Federation , Obstetrics, Gynecology and Perinatology, Department for Postgraduate Education, M. Sedina Str., 4 , Krasnodar 350063 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-4500","authenticated-orcid":false,"given":"Tatiana B.","family":"Makukhina","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Educational Institution of Higher Education , \u201cKuban State Medical University\u201d of the Ministry of Healthcare of the Russian Federation , Obstetrics, Gynecology and Perinatology, Department for Postgraduate Education, M. Sedina Str., 4 , Krasnodar 350063 , Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"2023040100004384926_j_jpm-2019-0261_ref_001_w2aab3b7c26b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Zosmer N, Fuller J, Shaikh H, Johns J, Ross JA. Natural history of early first-trimester pregnancies implanted in cesarean scars. 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