{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:22:54Z","timestamp":1771550574354,"version":"3.50.1"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2019-0474_abs_001_w2aab3b7c17b1b6b1aab1c15b1Aa\"><jats:title>Objectives<\/jats:title><jats:p>Our aim was to study the association of clinical variables obtainable before delivery for severe neonatal outcomes (SNO) and develop a clinical tool to calculate the prediction probability of SNO in preterm prelabor rupture of membranes (PPROM).<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2019-0474_abs_002_w2aab3b7c17b1b6b1aab1c15b2Aa\"><jats:title>Methods<\/jats:title><jats:p>This was a prospective study from October 2015 to May 2018. We included singleton pregnancies with PPROM and an estimated fetal weight (EFW) two weeks before delivery. We excluded those with fetal anomalies or fetal death. We examined the association between SNO and variables obtainable before delivery such as gestational age (GA) at PPROM, EFW, gender, race, body mass index, chorioamnioitis. SNO was defined as having at least one of the following: respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, neonatal sepsis, or neonatal death. The most parsimonious logistic regression models was constructed using the best subset selection model approach, and receiver operator curves were utilized to evaluate the prognostic accuracy of these clinical variables for SNO.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2019-0474_abs_003_w2aab3b7c17b1b6b1aab1c15b3Aa\"><jats:title>Results<\/jats:title><jats:p>We included 106 pregnancies, 42 had SNO (39.6%). The EFW (area under the receiver operating characteristic curve [AUC]=0.88) and GA at PPROM (AUC=0.83) were significant predictors of SNO. The addition of any of the other variables did not improve the predictive probability of EFW for the prediction of SNO.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2019-0474_abs_004_w2aab3b7c17b1b6b1aab1c15b4Aa\"><jats:title>Conclusions<\/jats:title><jats:p>The EFW had the strongest association with SNO in in our study among variables obtainable before delivery. Other variables had no significant effect on the prediction probability of the EFW. Our findings should be validated in larger studies.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2019-0474","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:29:02Z","timestamp":1594373342000},"page":"687-693","source":"Crossref","is-referenced-by-count":4,"title":["Estimated fetal weight and severe neonatal outcomes in preterm prelabor rupture of membranes"],"prefix":"10.1515","volume":"48","author":[{"given":"Jose R.","family":"Duncan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine M.","family":"Dorsett","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Bursac","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Department of Biostatistics, Florida International University, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario A.","family":"Cleves","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of South Florida, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay J.","family":"Talati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro H.","family":"Schenone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nornan L.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Mari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref101","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500\u00a0g","volume":"92","year":"1978","journal-title":"J Pediatr"},{"key":"ref191","first-page":"178","article-title":"Preterm premature rupture of the membranes","volume":"101","year":"2003","journal-title":"Obstet Gynecol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/jama.1997.03550120049032","article-title":"Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network","volume":"278","year":"1997","journal-title":"JAMA"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500\u00a0g","volume":"92","year":"1978","journal-title":"J Pediatr"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/01.AOG.0000259312.36053.02","article-title":"Development of a nomogram for prediction of vaginal birth after cesarean delivery","volume":"109","year":"2007","journal-title":"Obstet Gynecol"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9378(85)90298-4","article-title":"Estimation of fetal weight with the use of head, body, and femur measurements\u2014a prospective study","volume":"151","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/01.AOG.0000259312.36053.02","article-title":"Development of a nomogram for prediction of vaginal birth after cesarean delivery","volume":"109","year":"2007","journal-title":"Obstet Gynecol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0140-6736(00)04233-1","article-title":"Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group","volume":"357","year":"2001","journal-title":"Lancet"},{"key":"ref01","first-page":"178","article-title":"Preterm premature rupture of the membranes","volume":"101","year":"2003","journal-title":"Obstet Gynecol"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1542\/peds.107.1.e1","article-title":"Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network","volume":"107","year":"2001","journal-title":"Pediatrics"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ajog.2004.10.625","article-title":"Perinatal outcomes in women with preterm rupture of membranes between 24 and 32 weeks of gestation and a history of vaginal bleeding","volume":"193","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ajog.2004.10.625","article-title":"Perinatal outcomes in women with preterm rupture of membranes between 24 and 32 weeks of gestation and a history of vaginal bleeding","volume":"193","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/jama.1997.03550120049032","article-title":"Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network","volume":"278","year":"1997","journal-title":"JAMA"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/14767058.2018.1536744","article-title":"Fetal pulmonary artery acceleration\/ejection time prognostic accuracy for respiratory complications in preterm prelabor rupture of membranes","volume":"33","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref311","first-page":"1","article-title":"Uterine artery pulsatility index for the prediction of obstetrical complications in preterm prelabor rupture of membranes","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1056\/NEJMoa073059","article-title":"Intensive care for extreme prematurity--moving beyond gestational age","volume":"358","year":"2008","journal-title":"N Engl J Med"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/uog.19066","article-title":"Ultrasonographic estimation of fetal weight: development of new model and assessment of performance of previous models","volume":"52","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/0002-9378(92)91336-9","article-title":"Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients","volume":"166","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"e876","DOI":"10.1542\/peds.2013-0702","article-title":"Prediction of neonatal outcomes in extremely preterm neonates","volume":"132","year":"2013","journal-title":"Pediatrics"},{"key":"ref301","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"ref111","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.3109\/14767058.2015.1035643","article-title":"Neonatal outcome in women with preterm premature rupture of membranes (PPROM) between 18 and 26 weeks","volume":"29","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/0002-9378(92)91336-9","article-title":"Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients","volume":"166","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"ref141","first-page":"e196294","article-title":"Assessment of an updated neonatal research network extremely preterm birth outcome model in the vermont oxford network","year":"2020","journal-title":"JAMA Pediatr"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging","volume":"187","year":"1978","journal-title":"Ann Surg"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/14767058.2018.1536744","article-title":"Fetal pulmonary artery acceleration\/ejection time prognostic accuracy for respiratory complications in preterm prelabor rupture of membranes","volume":"33","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref331","first-page":"e196294","article-title":"Assessment of an updated neonatal research network extremely preterm birth outcome model in the vermont oxford network","year":"2020","journal-title":"JAMA Pediatr"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0140-6736(00)04233-1","article-title":"Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group","volume":"357","year":"2001","journal-title":"Lancet"},{"key":"ref121","first-page":"1","article-title":"Uterine artery pulsatility index for the prediction of obstetrical complications in preterm prelabor rupture of membranes","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9378(85)90298-4","article-title":"Estimation of fetal weight with the use of head, body, and femur measurements\u2014a prospective study","volume":"151","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/uog.19066","article-title":"Ultrasonographic estimation of fetal weight: development of new model and assessment of performance of previous models","volume":"52","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"e876","DOI":"10.1542\/peds.2013-0702","article-title":"Prediction of neonatal outcomes in extremely preterm neonates","volume":"132","year":"2013","journal-title":"Pediatrics"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging","volume":"187","year":"1978","journal-title":"Ann Surg"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1542\/peds.107.1.e1","article-title":"Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network","volume":"107","year":"2001","journal-title":"Pediatrics"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1056\/NEJMoa073059","article-title":"Intensive care for extreme prematurity--moving beyond gestational age","volume":"358","year":"2008","journal-title":"N Engl J Med"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.3109\/14767058.2015.1035643","article-title":"Neonatal outcome in women with preterm premature rupture of membranes (PPROM) between 18 and 26 weeks","volume":"29","year":"2016","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jpme\/48\/7\/article-p687.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2019-0474\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:37:26Z","timestamp":1619055446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2019-0474\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":36,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1515\/jpm-2019-0474","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,25]]}}}