{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:42:14Z","timestamp":1773484934871,"version":"3.50.1"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_jpm-2020-0160_abs_001_w2aab3b7c85b1b6b1aab1c15b1Aa\"><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effects of nifedipine treatment on fetal hemodynamics and cardiac function during preterm labor. This prospective study assessed several quantitative parameters of fetal cardiac circulation and function, and found no significant changes at 48\u00a0h after nifedipine treatment. These findings suggest that tocolytic nifedipine may be safe for fetuses. It supports clinicians to use nifedipine treatment for tocolysis without any cardiac effect on the fetus.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2020-0160_abs_002_w2aab3b7c85b1b6b1aab1c15b2Aa\"><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was conducted at a tertiary hospital between January 2016 and October 2017. A total of 45 pregnant women who required nifedipine for preterm labor were included in this study. Fetal Doppler ultrasound was performed and fetal systolic and diastolic function was measured prior to, and 48\u00a0h after, the first nifedipine treatment. Conventional Doppler parameters were used to evaluate fetal heart function and hemodynamic changes. Tricuspid annular plane systolic excursion, mitral annular plane systolic excursion and the sphericity index were also evaluated to assess changes in fetal cardiac morphology.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2020-0160_abs_003_w2aab3b7c85b1b6b1aab1c15b3Aa\"><jats:title>Results<\/jats:title><jats:p>No significant changes in fetal Doppler parameters were observed following nifedipine tocolysis. There was no significant difference in the fetal cardiac function parameters of both ventricles before vs. after nifedipine treatment. Tricuspid annular plane systolic excursion, mitral annular plane systolic excursion, and sphericity index values were unchanged following nifedipine treatment.<\/jats:p><\/jats:sec><jats:sec id=\"j_jpm-2020-0160_abs_004_w2aab3b7c85b1b6b1aab1c15b4Aa\"><jats:title>Conclusions<\/jats:title><jats:p>Oral administration of nifedipine did not to alter fetal cardiac function or morphology. Fetal cardiac parameters and various Doppler indices were unchanged following nifedipine treatment. Maternal nifedipine treatment does not appear to have any significant effect on fetal cardiac function.<\/jats:p><\/jats:sec>","DOI":"10.1515\/jpm-2020-0160","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T10:18:42Z","timestamp":1595931522000},"page":"723-727","source":"Crossref","is-referenced-by-count":4,"title":["Effects of nifedipine on fetal cardiac function in preterm labor"],"prefix":"10.1515","volume":"48","author":[{"given":"Osman","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Pediatric Cardiology, University of Health Sciences, Ankara Etlik Z\u00fcbeyde Han\u0131m Women\u2019s Health Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayhan \u015eule","family":"G\u00f6nc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinic of Perinatology, Ministry of Health Ankara City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref181","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/uog.16217","article-title":"Differential effect of assisted reproductive technology and small-for-gestational age on fetal cardiac remodeling","volume":"50","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"36","DOI":"10.5830\/CVJA-2016-053","article-title":"Myocardial dysfunction in children with intrauterine growth restriction: an echocardiographic study","volume":"28","year":"2017","journal-title":"Cardiovasc J Afr"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejogrb.2006.03.001","article-title":"Calcium channel blockers for tocolysis: a review of their role and safety following reports of serious adverse events","volume":"126","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod 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