{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:36:58Z","timestamp":1789133818706,"version":"build-2803163510"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jpm-2020-0163_abs_001_w2aab3b7c42b1b6b1aab1c15b2Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Myasthenia gravis (MG) is an autoimmune disease affecting the neuromuscular junction marked by weakness and fatiguability of skeletal muscle. MG has an unpredictable course in pregnancy. Our purpose was to evaluate the effect of MG on maternal and neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2020-0163_abs_002_w2aab3b7c42b1b6b1aab1c15b3Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the United States\u2019 Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 2005 to 2015, we conducted a retrospective cohort study consisting of women who delivered during that period. Multivariate logistic regression models, adjusted for baseline maternal demographics and comorbidities, were used to compare maternal and neonatal outcomes among pregnancies in women with and without MG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2020-0163_abs_003_w2aab3b7c42b1b6b1aab1c15b4Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, 974 deliveries were to women diagnosed with MG. Women with MG were more likely to be older, African American, obese, have Medicare insurance and be discharged from an urban teaching hospital. Women with MG were also more likely to have chronic hypertension, pre-gestational diabetes, hypothyroidism, and chronic steroid use. Women with MG were at greater risk for acute respiratory failure (OR 13.7, 95% CI 8.9\u201321.2) and increased length of hospital stay (OR 2.5, 95% CI 1.9\u20133.3). No significant difference was observed in the risk of preterm premature rupture of membranes, caesarean section or instrumental vaginal delivery. Neonates of women with MG were more likely to be premature (OR 1.4, 95% CI 1.2\u20131.8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jpm-2020-0163_abs_004_w2aab3b7c42b1b6b1aab1c15b5Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MG in pregnancy is a high-risk condition associated with greater risk of maternal respiratory failure and preterm birth. Management in a tertiary care center with obstetrical, neurological, anesthesia and neonatology collaboration is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jpm-2020-0163","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T03:21:00Z","timestamp":1597720860000},"page":"793-798","source":"Crossref","is-referenced-by-count":24,"title":["Maternal and neonatal outcomes among pregnant women with myasthenia gravis"],"prefix":"10.1515","volume":"48","author":[{"given":"Laura","family":"Nicholls-Dempsey","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Jewish General Hospital, McGill University , Montreal , QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Czuzoj-Shulman","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Community Studies, Jewish General Hospital , Montreal , QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim Arie","family":"Abenhaim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Jewish General Hospital, McGill University , Montreal , QC , Canada"},{"name":"Center for Clinical Epidemiology and Community Studies, Jewish General Hospital , Montreal , QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"2021021320132397524_j_jpm-2020-0163_ref_001_w2aab3b7c42b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Djelmis, J, Sostarko, M, Mayer, D, Ivanisevic, M. Myasthenia gravis in pregnancy: report on 69 cases. Eur J Obstet Gynecol Reprod Biol 2002;104:21\u20135, https:\/\/doi.org\/10.1016\/s0301-2115(02)00051-9.","DOI":"10.1016\/S0301-2115(02)00051-9"},{"key":"2021021320132397524_j_jpm-2020-0163_ref_002_w2aab3b7c42b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Ciafaloni, E, Massey, JM. Myasthenia gravis and pregnancy. Neurol Clin 2004;22:771\u201382, https:\/\/doi.org\/10.1016\/j.ncl.2004.06.003.","DOI":"10.1016\/j.ncl.2004.06.003"},{"key":"2021021320132397524_j_jpm-2020-0163_ref_003_w2aab3b7c42b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Tellez-Zenteno, JF, Hernandez-Ronquillo, L, Salinas, V, Estanol, B, da Silva, O. Myasthenia gravis and pregnancy: clinical implications and neonatal outcome. 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