{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:06:45Z","timestamp":1758809205034,"version":"3.40.5"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2020-0212_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the effect of altering vaginal pH on induction of labor in full-term pregnancies using Misoprostol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0212_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This randomized controlled trial was conducted at Kasralainy Hospital, Cairo University, Egypt and Algezeera Hospital, Egypt. A total of 218 healthy term primigravida pregnant women who were scheduled for pregnancy termination were recruited in the study. The included patients were divided into three groups; Group A: Those who received normal saline vaginal wash (0.9% NaCl), Group B: those who received alkaline vaginal wash (5% sodium bicarbonate) and Group C: those who received acidic vaginal wash (5% acetic acid). Patients received 25\u00a0\u03bcg of Misoprostol E1 (Vagiprost<jats:sup>\u00ae<\/jats:sup> Adwia Pharmaceuticals, Egypt) every 6\u00a0h for a maximum of 24\u00a0h (total of four potential doses).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0212_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The \u2018acid\u2019 group participants took a mean time of 20.46\u00a0h to reach active stage of labor, followed by the \u2018normal saline\u2019 group with 21.45\u00a0h and the \u2018alkaline\u2019 group with 22.59\u00a0h. The difference between the groups was statistically significant, with a p-value of 0.013.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0212_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Douching the vagina with acidic solution seems to supplement the effect of Misoprostol on inducing labor in full-term pregnancies, as evidenced by having the shortest mean time needed to reach active stage of labor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2020-0212","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T16:29:57Z","timestamp":1604680197000},"page":"43-49","source":"Crossref","is-referenced-by-count":4,"title":["Comparative study regarding effect of pH on Misoprostol in induction of labor in full term primigravida pregnant women, a double blind randomized controlled trial"],"prefix":"10.1515","volume":"49","author":[{"given":"Ahmed S. S. A.","family":"Rashwan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8429-6376","authenticated-orcid":false,"given":"Mahmoud","family":"Alalfy","sequence":"additional","affiliation":[{"name":"Reproductive Health and Family Planning Department, National Research Centre , Aljazeerah Hospital , Giza , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"el-sharkawy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelfatah","family":"Eldesouky","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed SA","family":"Ashour","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Alebrashy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Bakry","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"2023033121512592302_j_jpm-2020-0212_ref_001","unstructured":"Allen, R, O\u2019Brien, B. Uses of misoprostol in obstetrics and gynecology. Rev Obstet Gynecol 2009;2:159\u201368. https:\/\/doi.org\/10.3909\/riog0055."},{"key":"2023033121512592302_j_jpm-2020-0212_ref_002","unstructured":"Marc, B. Pharmacokinetics of prostaglandins. Stockholm: Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Hospital; 2001."},{"key":"2023033121512592302_j_jpm-2020-0212_ref_003","doi-asserted-by":"crossref","unstructured":"Moore, L, Rayburn, W. Elective induction of labor. Clin Obstet Gynecol 2006;49:698\u2013704. https:\/\/doi.org\/10.1097\/00003081-200609000-00026.","DOI":"10.1097\/00003081-200609000-00026"},{"key":"2023033121512592302_j_jpm-2020-0212_ref_004","doi-asserted-by":"crossref","unstructured":"Karim, H, Abbas, A, Amr, N, Al-Sharaky, A, Alaa-Eddin, I. Effect of vaginal pH on the efficacy of misoprostol for induction of midtrimester abortion. J Obstet Gynaecol Res 2008;34:78\u201384. https:\/\/doi.org\/10.1111\/j.1447-0756.2007.00683.x.","DOI":"10.1111\/j.1447-0756.2007.00683.x"},{"key":"2023033121512592302_j_jpm-2020-0212_ref_005","doi-asserted-by":"crossref","unstructured":"Tang, OS, Miao, BY, Lee, SWH, Ho, PC. Pilot study on the use of repeated doses of sublingual misoprostol in termination of pregnancy up to 12 weeks gestation. Hum Reprod 2002;17:654\u20138. https:\/\/doi.org\/10.1093\/humrep\/17.3.654.","DOI":"10.1093\/humrep\/17.3.654"},{"key":"2023033121512592302_j_jpm-2020-0212_ref_006","unstructured":"Najafian, A, Rajaei, M, Beheshti, S. Efficacy of vaginal misoprostol and vaginal washing with 3% acetic acid for first trimester pregnancy termination: a randomized single blind clinical trial. Hormozgan Med J 2017;20:301\u20136."},{"key":"2023033121512592302_j_jpm-2020-0212_ref_007","unstructured":"Behrooz, A, Shahbazian, N, Ghanavati, N. Effects of vaginal pH on the efficacy of vaginal misoprostol for induction of midtrimester abortion. Int J Pharm Res Allied Sci 2016;5:211\u201320."},{"key":"2023033121512592302_j_jpm-2020-0212_ref_008","doi-asserted-by":"crossref","unstructured":"Ramsey, P, Ogburn, PJr, Harris, D, Heise, R, Ramin, K. Effect of vaginal pH on efficacy of misoprostol for cervical ripening and labor induction. Am J Obstet Gynecol 2000;182:1616\u20139. https:\/\/doi.org\/10.1067\/mob.2000.107441.","DOI":"10.1067\/mob.2000.107441"},{"key":"2023033121512592302_j_jpm-2020-0212_ref_009","unstructured":"Wing, DA, Lockwood, CJ, Barss, VA. Induction of labour. 2017."},{"key":"2023033121512592302_j_jpm-2020-0212_ref_010","unstructured":"Josie, L Ternore. Methods of cervical ripening and induction of labor. Am Fam Physician 2003;67:2123\u20138."},{"key":"2023033121512592302_j_jpm-2020-0212_ref_011","unstructured":"Harman, JHJr, Kim, A. Current trends in cervical ripening and induction. Am Fam Physician 1999;60:477\u201384."},{"key":"2023033121512592302_j_jpm-2020-0212_ref_012","doi-asserted-by":"crossref","unstructured":"Miller, E, Beasley, D, Dunn, R, Archie, E. Lactobacilli dominance and vaginal pH: why is the human vaginal microbiome unique?. Front Microbiol 2016;7:1936. https:\/\/doi.org\/10.3389\/fmicb.2016.01936.","DOI":"10.3389\/fmicb.2016.01936"},{"key":"2023033121512592302_j_jpm-2020-0212_ref_013","doi-asserted-by":"crossref","unstructured":"Zanzani, M, Kohpayeh, J, Karimi, Z. The effect of vaginal pH on the efficacy of vaginal misoprostol for the induction of midtrimester pregnancy termination. Obstet Gynecol Cancer Res 2017;2:e8953. https:\/\/doi.org\/10.5812\/ogcr.8953.","DOI":"10.17795\/ogcr-8953"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jpme\/49\/1\/article-p43.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2020-0212\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2020-0212\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T11:17:32Z","timestamp":1680347852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2020-0212\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12,2]]},"published-print":{"date-parts":[[2021,1,26]]}},"alternative-id":["10.1515\/jpm-2020-0212"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2020-0212","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"type":"print","value":"0300-5577"},{"type":"electronic","value":"1619-3997"}],"subject":[],"published":{"date-parts":[[2020,8,18]]}}}