{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T15:26:22Z","timestamp":1773501982834,"version":"3.50.1"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2020-0243_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Gastroesophageal reflux may exacerbate chronic lung disease in preterm infants. We evaluated the short-term effects of transpyloric feeding on respiratory status in preterm infants during mechanical ventilation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0243_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively collected data from the hospital information management system. To evaluate the effect of transpyloric feeding on oxygenation, we compared changes in SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratios before and after commencing transpyloric feeding by a piecewise linear regression model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0243_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We examined 33 infants (median gestational age, 25.4\u00a0weeks; median birth weight, 656\u00a0g) who underwent transpyloric feeding. All tubes were placed at the bedside without fluoroscopy. No cases of unsuccessful placement, gastroduodenal perforation, or tracheal misinsertion occurred. Transpyloric feeding began at a median age of 18 (interquartile range, 15\u201323) days. Mean SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> (\u00b1SD) ratios were 391 (\u00b149), 371 (\u00b151), 365 (\u00b156), and 366 (\u00b153) 72\u201396\u00a0h before, 0\u201324\u00a0h before, 48\u201372\u00a0h after, and 96\u2013120\u00a0h after starting transpyloric feeding, respectively. The rate of change per hour of SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratios increased 48\u2013120\u00a0h after compared with 0\u201396\u00a0h before transpyloric feeding (0.03 [95% confidence interval,\u00a0\u22120.10 to 0.17] vs.\u00a0\u22120.29 [\u22120.47 to\u00a0\u22120.12]) (p=0.007). No apparent changes occurred in the mean airway pressure, amplitude pressure, or pCO<jats:sub>2<\/jats:sub>.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0243_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Transpyloric feeding during mechanical ventilation can prevent the deterioration of oxygenation without major complications at the stage of respiratory exacerbation in preterm infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2020-0243","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:14:59Z","timestamp":1605600899000},"page":"383-387","source":"Crossref","is-referenced-by-count":6,"title":["Acute respiratory effect of transpyloric feeding for respiratory exacerbation in preterm infants"],"prefix":"10.1515","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-475X","authenticated-orcid":false,"given":"Tomoyuki","family":"Shimokaze","sequence":"first","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0696-9659","authenticated-orcid":false,"given":"Kouji","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Medicine , Yokohama City University , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesia , Kanagawa Children\u2019s Medical Center , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-9907","authenticated-orcid":false,"given":"Katsuaki","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Katsumata","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neonatology , Kanagawa Children\u2019s Medical Center , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"2023092212122984291_j_jpm-2020-0243_ref_001","doi-asserted-by":"crossref","unstructured":"Jolley, SG, Herbst, JJ, Johnson, DG, Matlak, ME, Book, LS. Esophageal pH monitoring during sleep identifies children with respiratory symptoms from gastroesophageal reflux. Gastroenterology 1981;80:1501\u20136. https:\/\/doi.org\/10.1016\/0016-5085(81)90264-x.","DOI":"10.1016\/0016-5085(81)90264-X"},{"key":"2023092212122984291_j_jpm-2020-0243_ref_002","doi-asserted-by":"crossref","unstructured":"Farhath, S, He, Z, Nakhla, T, Saslow, J, Soundar, S, Camacho, J, et al.. Pepsin, a marker of gastric contents, is increased in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. Pediatrics 2008;121:e253\u20139. https:\/\/doi.org\/10.1542\/peds.2007-0056.","DOI":"10.1542\/peds.2007-0056"},{"key":"2023092212122984291_j_jpm-2020-0243_ref_003","doi-asserted-by":"crossref","unstructured":"Akinola, E, Rosenkrantz, TS, Pappagallo, M, McKay, K, Hussain, N. Gastroesophageal reflux in infants < 32\u00a0weeks gestational age at birth: lack of relationship to chronic lung disease. 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