{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:07:14Z","timestamp":1784920034132,"version":"3.55.0"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"name":"Scientific Initiation Seed Program at Cesmac University Center\u00a0\u2013 SANTANDER","award":["2018\u20132019"],"award-info":[{"award-number":["2018\u20132019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2020-0313_abs_001_w2aab3b7c29b1b6b1aab1c15b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Identifying and understanding the main risk factors associated with extubation failure of very low birthweight (VLBW) infants in different populations can subsequently help in establishing better criteria while taking decision of extubation. The aim of the study was to identify factors associated with extubation failure in VLBW infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0313_abs_002_w2aab3b7c29b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cohort study of VLBW infants who underwent their first extubation between April 2018 and December 2019 in a Neonatal Intensive Care Unit, Alagoas, Brazil, were included in this study. Extubation failure was defined as reintubation within seven days of extubation. Relative risks of predictive variables different between the extubation success group (ES) and extubation failure group (EF) were estimated with a robust Poisson regression model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0313_abs_003_w2aab3b7c29b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of the 112 infants included, 26 (23%) cases exhibited extubation failure. Extremely low birth weight (RR 2.55, 95% CI 1.07, 6.06), mechanical ventilation duration for first extubation greater than seven days (RR 2.66, 95% CI 1.10, 6.45), vaginal delivery (RR 2.07, 95% CI 1.03, 4.18) and maternal chorioamnionitis (RR 4.89, 95% CI 1.26\u201318.98) remained independently associated with extubation failure. EF had a significant greater need for respiratory support, longer oxygen therapy duration, more bronchopulmonary dysplasia (BPD) and longer length of hospital stay, even when adjusted for confounding variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0313_abs_004_w2aab3b7c29b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Extremely low birth weight infants needing mechanical ventilation, wherein the duration for first extubation was longer than seven days, with vaginal delivery and maternal chorioamnionitis failed more frequently at the first attempt of extubation. And this failure increased the risk of BPD and the length of hospital stay.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2020-0313","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T10:48:43Z","timestamp":1608634123000},"page":"506-513","source":"Crossref","is-referenced-by-count":13,"title":["Factors associated with extubation failure in very low birth weight infants: a cohort study in the northeast Brazil"],"prefix":"10.1515","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4227-9172","authenticated-orcid":false,"given":"Raphaela Farias","family":"Teixeira","sequence":"first","affiliation":[{"name":"Graduate Program in Health Sciences , Federal University of Sergipe , Aracaju , Sergipe , Brazil"},{"name":"CESMAC University Centre , Macei\u00f3 , Alagoas , Brazil"},{"name":"Santa Monica Maternity School Hospital , Macei\u00f3 , Alagoas , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia Maria","family":"Costa","sequence":"additional","affiliation":[{"name":"Santa Monica Maternity School Hospital , Macei\u00f3 , Alagoas , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Maria de Abreu","sequence":"additional","affiliation":[{"name":"CESMAC University Centre , Macei\u00f3 , Alagoas , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cicero Amsterdan","family":"Lessa","sequence":"additional","affiliation":[{"name":"CESMAC University Centre , Macei\u00f3 , Alagoas , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Carla","family":"Carvalho","sequence":"additional","affiliation":[{"name":"CESMAC University Centre , Macei\u00f3 , Alagoas , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir Buainain","family":"Kassar","sequence":"additional","affiliation":[{"name":"CESMAC University Centre , Macei\u00f3 , Alagoas , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikaro Daniel","family":"Barreto","sequence":"additional","affiliation":[{"name":"Federal Rural University of Pernambuco , Recife , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Queiroz","family":"Gurgel","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences , Federal University of Sergipe , Aracaju , Sergipe , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Monteiro","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences , Federal University of Sergipe , Aracaju , Sergipe , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"2023040100375558396_j_jpm-2020-0313_ref_001_w2aab3b7c29b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Blencowe, H, Krasevec, J, de Onis, M, Blencowe, H, Krasevec, J, de Onis, M, et al.. 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