{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:55:40Z","timestamp":1790963740727,"version":"4.1.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2020-0318_abs_001_w2aab3b7c33b1b6b1aab1c15b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Vitamin D plays an important role in the release of the placenta and implantation, and low levels are a risk factor for pre-eclampsia. Studies have also shown that symptomatic treatment of vitamin D3 deficiency can effectively reduce the risk of pre-eclampsia. In this study, vitamin D3 supplementation was performed on the risk of pre-eclampsia to observe its effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0318_abs_002_w2aab3b7c33b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From January 2016 to December 2018, 450 women with maternal treatment and delivery in our hospital underwent an open-label randomized study. The pregnant women were divided into low-dose, medium-dose, and high-dose groups. Compare the incidence of pre-eclampsia and the dose effect of vitamin D levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0318_abs_003_w2aab3b7c33b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the maternal and perinatal periods of the 450 maternal women, the 25[OH] index of the three groups of pregnant women was significantly increased, while the high-dose increase index was more obvious. The relative risk reduction rate was significantly lower. Compared with the low-dose and middle-dose groups, the high-dose group had a significantly lower incidence of pre-eclampsia, while the IUGR index was lower, and other obstetric indicators were comparable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0318_abs_004_w2aab3b7c33b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Vitamin D supplementation can effectively reduce the incidence of pre-eclampsia, while reducing the IUGR index, which has important value and significance in its clinical application.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2020-0318","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T14:56:47Z","timestamp":1608649007000},"page":"480-484","source":"Crossref","is-referenced-by-count":19,"title":["Effect of vitamin D3 supplementation during pregnancy on high risk factors \u2014 a randomized controlled trial"],"prefix":"10.1515","volume":"49","author":[{"given":"Jiang","family":"Xiaomang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Chang\u2019an Hospital , Xi\u2019an , Shaanxi Province , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yanling","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Xijing Hospital of the Air Force Military Medical University , Xi\u2019an , Shaanxi Province , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"2023040100375546454_j_jpm-2020-0318_ref_001_w2aab3b7c33b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Kassai, MS, Cafeo, FR, Affonso-Kaufman, FA, Suano-Souza, FI, Sarni, ROS. Vitamin D plasma concentrations in pregnant women and their preterm newborns. 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