{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:53:28Z","timestamp":1777301608755,"version":"3.51.4"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2020-0482_abs_001_w2aab3b7c42b1b6b1aab1c15b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The maturation of the sympathetic nervous system (SNS) occurs steadily throughout gestation while the myelinated vagus has accelerated maturation periods, between 25 and 32\u00a0weeks of gestation and a further increase around 37\u201338\u00a0weeks of gestation. The aim was to quantify the cardiac autonomic regulation maturation, as a function of gestational age (GA) in a cohort of low risk preterm infants born between 28 and 32\u00a0weeks of gestation by assessing heart rate variability (HRV) at week 32, and at week 35 postmenstrual age (PMA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0482_abs_002_w2aab3b7c42b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Forty preterm infants were recruited, 24\u00a0h recordings of breathing rate and RR intervals were obtained at week 32 and week 35 PMA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0482_abs_003_w2aab3b7c42b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A significant difference was noted between preterm infants born before 32\u00a0weeks GA and preterm infants born at week 32; the latter present higher HRV values throughout the follow-up period. No significant change over time was noted for the parasympathetic HRV measures while a significant increase was found in the sympathetic system. Moreover, a significant interaction effect of time and system was found, the increase in values of the sympathetic system over time was significantly larger than the change noted in the vagal HRV measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2020-0482_abs_004_w2aab3b7c42b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Given the beneficial influence of vagal tone on health and developmental outcomes in preterm infants, the findings of the current study highlight the need for further studies on the impact of specifics gestational age on vagal development and later assessing interventions associate with its continue development and maturation at these specific periods.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2020-0482","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T12:32:02Z","timestamp":1613824322000},"page":"624-629","source":"Crossref","is-referenced-by-count":10,"title":["Maturation of the cardiac autonomic regulation system, as function of gestational age in a cohort of low risk preterm infants born between 28 and 32\u00a0weeks of gestation"],"prefix":"10.1515","volume":"49","author":[{"given":"Israeli-Mendlovic","family":"Hadas","sequence":"first","affiliation":[{"name":"Physical Therapy Department , School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-141X","authenticated-orcid":false,"given":"Mendlovic","family":"Joseph","sequence":"additional","affiliation":[{"name":"Shaare\u2013Zedek Medical Center , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuk","family":"Luba","sequence":"additional","affiliation":[{"name":"Physical Therapy Department , School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katz-Leurer","family":"Michal","sequence":"additional","affiliation":[{"name":"Physical Therapy Department , School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"2023033123480308590_j_jpm-2020-0482_ref_001_w2aab3b7c42b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Mulkey, SB, Plessis, AD. 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