{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:25:34Z","timestamp":1754162734947,"version":"3.41.2"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0131_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To compare between the effectiveness and safety of two different daily doses of vaginal progesterone (400 vs. 200\u00a0mg) in the prevention of preterm labor in twin pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0131_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a prospective single-blinded randomized controlled trial conducted on 100 primi-gravida who had twin pregnancy and attended the antenatal clinic of a University hospital. They were equally and randomly allocated into two arms each containing 50 patients. Arm 1 received 400\u00a0mg and arm 2 received 200\u00a0mg vaginal progesterone daily at bed time starting from 14\u00a0weeks of pregnancy to 36\u00a0weeks. Transvaginal ultrasound was performed for assessment of the length of cervix at 14 and 22\u00a0weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0131_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Both arms of the current study were comparable regarding the cervical length at 14 and 22\u00a0weeks, mean gestational age at delivery, incidence of pre-term delivery, birth weight of the first twin. Second twin in addition to the average weight of both twins. No statistical significance differences between two arms regarding incidence of early neonatal death. NICU, mechanical ventilation, length of admission in NICU for the first twin. Second twin as well as both twins.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0131_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Vaginal progesterone treatment with different doses was tolerable, but wasn\u2019t effective in the prevention of preterm labor in twin pregnancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0131","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:55:04Z","timestamp":1631667304000},"page":"294-299","source":"Crossref","is-referenced-by-count":2,"title":["A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200\u00a0mg for prevention of preterm labor in twin gestations"],"prefix":"10.1515","volume":"50","author":[{"given":"Ahmed S.","family":"Abdel Wahab","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ain-Shams University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa I.","family":"Abdelmonaem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ain-Shams University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walaa M.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ras-Eltein Hospital , Alexandria , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed E.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ain-Shams University , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"2025073014015836175_j_jpm-2021-0131_ref_001","doi-asserted-by":"crossref","unstructured":"Liu, L, Oza, S, Hogan, D, Chu, Y, Perin, J, Zhu, J, et al.. Global, regional, and national causes of under-5 mortality in 2000\u201315: an updated systematic analysis with implications for the sustainable development goals. Lancet 2016;388:3027\u201335. https:\/\/doi.org\/10.1016\/s0140-6736(16)31593-8.","DOI":"10.1016\/S0140-6736(16)31593-8"},{"key":"2025073014015836175_j_jpm-2021-0131_ref_002","doi-asserted-by":"crossref","unstructured":"Saigal, S, Doyle, L. Preterm birth 3. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 2008;371:261\u20139. https:\/\/doi.org\/10.1016\/s0140-6736(08)60136-1.","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"2025073014015836175_j_jpm-2021-0131_ref_003","doi-asserted-by":"crossref","unstructured":"Goldenberg, R, Culhane, J, Iams, J, Romero, R. Preterm birth 1. Epidemiology and causes of preterm birth. 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