{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:25:22Z","timestamp":1704961522532},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0133_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Preeclampsia with severe features (PECsf) is\u00a0a\u00a0common disease in pregnant women. let-7a and IFN-gamma (interferon-gamma) are involved in diagnosis and prognosis of preeclampsia. This study explored effects of let-7a and IFN-gamma on PECsf patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0133_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The placental tissue of 21\u00a0PECsf, 19 preeclampsia without severe features (PEC), and 20 normal pregnant women were collected, and clinical data were recorded. let-7a and IFN-gamma expressions in placental tissue were detected. The correlation between let-7a\/IFN-gamma expression and clinical indexes was analyzed. According to let-7a and IFN-gamma expressions, PECsf patients were assigned into Hlet-7a group (let-7a high expression group), Llet-7a group (let-7a low expression group), HIFN-gamma group (IFN-gamma high expression group) and LIFN-gamma group (IFN-gamma low expression group). The incidence of adverse prognosis was compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0133_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>let-7a and IFN-gamma were highly expressed in placental tissue of preeclampsia patients, with significant differences between PEC and PECsf. The high expressions of let-7a and IFN-gamma were positively correlated with mean arterial pressure, lactate dehydrogenase, and 24\u00a0h urinary protein in placental tissues of PECsf patients. High let-7a and IFN-gamma expressions were correlated with adverse outcomes of PECsf.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0133_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>High let-7a and IFN-gamma expressions were correlated with clinical features, and could be used as biomarkers for treatment and poor prognosis of PECsf.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0133","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T22:05:01Z","timestamp":1653084301000},"page":"1142-1149","source":"Crossref","is-referenced-by-count":1,"title":["Expression pattern and clinical significance of microRNA-let-7a and IFN-gamma in placental tissue of patients with preeclampsia with severe features"],"prefix":"10.1515","volume":"50","author":[{"given":"Liping","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Daqing Longnan Hospital , Daqing , Heilongjiang , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojie","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Daqing Longnan Hospital , Daqing , Heilongjiang , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Daqing Longnan Hospital , Daqing , Heilongjiang , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"2023092212342441449_j_jpm-2021-0133_ref_001","doi-asserted-by":"crossref","unstructured":"Filipek, A, Jurewicz, E. [Preeclampsia - a disease of pregnant women]. Postepy Biochem 2018;64:232\u201329. https:\/\/doi.org\/10.18388\/pb.2018_146.","DOI":"10.18388\/pb.2018_146"},{"key":"2023092212342441449_j_jpm-2021-0133_ref_002","doi-asserted-by":"crossref","unstructured":"Pinheiro, MB, Gomes, KB, Ronda, CR, Guimaraes, GG, Freitas, LG, Teixeira-Carvalho, A, et al.. Severe preeclampsia: association of genes polymorphisms and maternal cytokines production in Brazilian population. Cytokine 2015;71:232\u20137. https:\/\/doi.org\/10.1016\/j.cyto.2014.10.021.","DOI":"10.1016\/j.cyto.2014.10.021"},{"key":"2023092212342441449_j_jpm-2021-0133_ref_003","doi-asserted-by":"crossref","unstructured":"Rana, S, Lemoine, E, Granger, JP, Karumanchi, SA. Correction to: preeclampsia: pathophysiology, challenges, and perspectives. Circ Res 2020;126:e8. https:\/\/doi.org\/10.1161\/RES.0000000000000315.","DOI":"10.1161\/RES.0000000000000315"},{"key":"2023092212342441449_j_jpm-2021-0133_ref_004","doi-asserted-by":"crossref","unstructured":"Bokslag, A, van Weissenbruch, M, Mol, BW, de Groot, CJ. Preeclampsia; short and long-term consequences for mother and neonate. Early Hum Dev 2016;102:47\u201350. https:\/\/doi.org\/10.1016\/j.earlhumdev.2016.09.007.","DOI":"10.1016\/j.earlhumdev.2016.09.007"},{"key":"2023092212342441449_j_jpm-2021-0133_ref_005","doi-asserted-by":"crossref","unstructured":"Paauw, ND, Lely, AT. Cardiovascular sequels during and after preeclampsia. Adv Exp Med Biol 2018;1065:455\u201370. https:\/\/doi.org\/10.1007\/978-3-319-77932-4_28.","DOI":"10.1007\/978-3-319-77932-4_28"},{"key":"2023092212342441449_j_jpm-2021-0133_ref_006","doi-asserted-by":"crossref","unstructured":"Newman, MG, Robichaux, AG, Stedman, CM, Jaekle, RK, Fontenot, MT, Dotson, T, et al.. Perinatal outcomes in preeclampsia that is complicated by massive proteinuria. Am J Obstet Gynecol 2003;188:264\u20138. https:\/\/doi.org\/10.1067\/mob.2003.84.","DOI":"10.1067\/mob.2003.84"},{"key":"2023092212342441449_j_jpm-2021-0133_ref_007","doi-asserted-by":"crossref","unstructured":"Nischintha, S, Pallavee, P, Ghose, S. Correlation between 24-h urine protein, spot urine protein\/creatinine ratio, and serum uric acid and their association with fetomaternal outcomes in preeclamptic women. J Nat Sci Biol Med 2014;5:255\u201360. https:\/\/doi.org\/10.4103\/0976-9668.136151.","DOI":"10.4103\/0976-9668.136151"},{"key":"2023092212342441449_j_jpm-2021-0133_ref_008","doi-asserted-by":"crossref","unstructured":"Bramham, K, Poli-de-Figueiredo, CE, Seed, PT, Briley, AL, Poston, L, Shennan, AH, et al.. Association of proteinuria threshold in pre-eclampsia with maternal and perinatal outcomes: a nested case control cohort of high risk women. 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