{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T09:20:04Z","timestamp":1770542404644,"version":"3.49.0"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2021-0142_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of the study was to evaluate the effect of the brain-sparing effect (BSE) of fetal growth restriction (FGR) in newborn germinal matrix\/intraventricular hemorrhage (GM\/IVH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0142_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 320 patients who delivered prior to the 34th gestational week were analyzed from data records. 201 patients were divided into two groups according to cerebro-placental ratio (CPR): early fetal growth restriction (FGR) with abnormal CPR group (n=104) and appropriate for gestational age with normal Doppler group (control) (n=97). Using the normal middle cerebral artery (MCA) Doppler as a reference, multivariate logistic regression analysis was used to assess the association between the BSE and the primary outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0142_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The rate of Grade I\u2013II germinal matrix\/intraventricular hemorrhage (GM\/IVH) was 31(29.8%) in the group possessing early FGR with abnormal CPR and 7(7.2%) in the control group, showing a statistically significant difference. The rate of grade III\u2013IV GM\/IVH was 7(6.7%) in the group possessing early FGR with abnormal CPR and 2 (2.1%) in the control group, showing no statistically significant difference. We found that gestational age at delivery &lt;32\u00a0weeks was an independent risk factor for GM\/IVH. In addition, we found that other variables such as the presence of preeclampsia, fetal weight percentile &lt;10, emergency CS delivery, 48-h completion after the first steroid administration and 24-h completion rate after MgSO<jats:sub>4<\/jats:sub> administration were not independently associated with the primary outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2021-0142_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results indicate that the rate of GM-IVH was increased in the group possessing early FGR with abnormal CPR; however, multivariate logistic regression analysis showed that BSE was not an independent risk factor for GM\/IVH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2021-0142","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T22:09:16Z","timestamp":1626818956000},"page":"93-99","source":"Crossref","is-referenced-by-count":6,"title":["The role of the brain-sparing effect of growth-restricted fetuses in newborn germinal matrix\/intraventricular hemorrhage"],"prefix":"10.1515","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9750-1594","authenticated-orcid":false,"given":"Mehmet Mete","family":"Kirlangic","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Tuzla Government Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdem","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Erciyes University Medicine Faculty , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-2991","authenticated-orcid":false,"given":"Yusuf","family":"Madendag","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Erciyes University Medicine Faculty , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Vural Yalman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Erciyes University Medicine Faculty , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Akdemir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Kayseri City Hospital , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mefkure","family":"Eraslan Sahin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Kayseri City Hospital , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6700-2236","authenticated-orcid":false,"given":"Ilknur","family":"Col Madendag","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Kayseri City Hospital , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Acmaz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Erciyes University Medicine Faculty , Kayseri , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"2022011210063976388_j_jpm-2021-0142_ref_001","doi-asserted-by":"crossref","unstructured":"Obstetricians ACo, Gynecologists. ACOG Practice Bulletin No. 204: fetal growth restriction. Obstet Gynecol 2019;133:e97\u2013e109, https:\/\/doi.org\/10.1097\/AOG.0000000000003070.","DOI":"10.1097\/AOG.0000000000003070"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_002","doi-asserted-by":"crossref","unstructured":"Flood, K, Unterscheider, J, Daly, S, Geary, MP, Kennelly, MM, McAuliffe, FM, et al.. The role of brain sparing in the prediction of adverse outcomes in intrauterine growth restriction: results of the multicenter PORTO Study. Am J Obstet Gynecol 2014;211:288 e1\u20135, https:\/\/doi.org\/10.1016\/j.ajog.2014.05.008.","DOI":"10.1016\/j.ajog.2014.05.008"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_003","doi-asserted-by":"crossref","unstructured":"Moreta, D, Vo, S, Eslick, GD, Benzie, R. Re-evaluating the role of cerebro placental ratio in predicting adverse perinatal outcome. Eur J Obstet Gynecol Reprod Biol 2019;242:17\u201328, https:\/\/doi.org\/10.1016\/j.ejogrb.2019.06.033.","DOI":"10.1016\/j.ejogrb.2019.06.033"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_004","doi-asserted-by":"crossref","unstructured":"Conde-Agudelo, A, Villar, J, Kennedy, SH, Papageorghiou, AT. Predictive accuracy of cerebro placental ratio for adverse perinatal and neurodevelopmental outcomes in suspected fetal growth restriction: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2018;52:430\u201341, https:\/\/doi.org\/10.1002\/uog.19117.","DOI":"10.1002\/uog.19117"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_005","doi-asserted-by":"crossref","unstructured":"Monteith, C, Flood, K, Mullers, S, Unterscheider, J, Breathnach, F, Daly, S, et al.. Evaluation of normalization of cerebro-placental ratio as a potential predictor for adverse outcome in SGA fetuses. Am J Obstet Gynecol 2017;216:285.e1\u20136. https:\/\/doi.org\/10.1016\/j.ajog.2016.11.1008.","DOI":"10.1016\/j.ajog.2016.11.1008"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_006","doi-asserted-by":"crossref","unstructured":"Reubsaet, P, Brouwer, AJ, van Haastert, IC, Brouwer, MJ, Koopman, C, Groenendaal, F, et al.. The impact of low-grade germinal matrix-intraventricular hemorrhage on neurodevelopmental outcome of very preterm infants. Neonatology 2017;112:203\u201310, https:\/\/doi.org\/10.1159\/000472246.","DOI":"10.1159\/000472246"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_007","doi-asserted-by":"crossref","unstructured":"Bassan, H. Intracranial hemorrhage in the preterm infant: understanding it, preventing it. Clin Perinatol 2009;36:737\u201362, https:\/\/doi.org\/10.1016\/j.clp.2009.07.014.","DOI":"10.1016\/j.clp.2009.07.014"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_008","doi-asserted-by":"crossref","unstructured":"Inder, TE, Perlman, JM, Volpe, JJ. Chapter 24 - preterm intraventricular hemorrhage\/posthemorrhagic hydrocephalus. In: Volpe\u2019s neurology of the newborn. Philadelphia, PA: Elsevier; 2018:637\u201398.e21 pp.","DOI":"10.1016\/B978-0-323-42876-7.00024-7"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_009","doi-asserted-by":"crossref","unstructured":"Gordijn, S, Beune, I, Thilaganathan, B, Papageorghiou, A, Baschat, A, Baker, P, et al.. Consensus definition of fetal growth restriction: a Delphi procedure. Ultrasound Obstet Gynecol 2016;48:333\u20139, https:\/\/doi.org\/10.1002\/uog.15884.","DOI":"10.1002\/uog.15884"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_010","doi-asserted-by":"crossref","unstructured":"Flood, K, Unterscheider, J, Daly, S, Geary, MP, Kennelly, MM, McAuliffe, FM, et al.. The role of brain sparing in the prediction of adverse outcomes in intrauterine growth restriction: results of the multicenter PORTO Study. Am J Obstet Gynecol 2014;211:288.el\u20135. https:\/\/doi.org\/10.1016\/j.ajog.2014.05.008.","DOI":"10.1016\/j.ajog.2014.05.008"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_011","doi-asserted-by":"crossref","unstructured":"Magee, L, Sawchuck, D, Synnes, A, von Dadelszen, P. Magnesium sulphate for fetal neuroprotection consensus C, maternal fetal medicine C: SOGC clinical practice guideline. Magnesium sulphate for fetal neuroprotection. J Obstet Gynaecol Can 2011;33:516\u201329, https:\/\/doi.org\/10.1016\/S1701-2163(16)34886-1.","DOI":"10.1016\/S1701-2163(16)34886-1"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_012","doi-asserted-by":"crossref","unstructured":"Perlman, JM, editor. The relationship between systemic hemodynamic perturbations and periventricular-intraventricular hemorrhage \u2013 a historical perspective. Semin Pediatr Neurol 2009;16:191\u20139. https:\/\/doi.org\/10.1016\/j.spen.2009.09.006.","DOI":"10.1016\/j.spen.2009.09.006"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_013","doi-asserted-by":"crossref","unstructured":"O\u2019Leary, H, Gregas, MC, Limperopoulos, C, Zaretskaya, I, Bassan, H, Soul, JS, et al.. Elevated cerebral pressure passivity is associated with prematurity-related intracranial hemorrhage. Pediatrics 2009;124:302\u20139, https:\/\/doi.org\/10.1542\/peds.2008-2004.","DOI":"10.1542\/peds.2008-2004"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_014","doi-asserted-by":"crossref","unstructured":"Tsuji, M, Saul, JP, du Plessis, A, Eichenwald, E, Sobh, J, Crocker, R, et al.. Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics 2000;106:625\u201332, https:\/\/doi.org\/10.1542\/peds.106.4.625.","DOI":"10.1542\/peds.106.4.625"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_015","doi-asserted-by":"crossref","unstructured":"Soul, JS, Hammer, PE, Tsuji, M, Saul, JP, Bassan, H, Limperopoulos, C, et al.. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res 2007;61:467\u201373, https:\/\/doi.org\/10.1203\/pdr.0b013e31803237f6.","DOI":"10.1203\/pdr.0b013e31803237f6"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_016","doi-asserted-by":"crossref","unstructured":"Noori, S, Seri, I, editors. Hemodynamic antecedents of peri\/intraventricular hemorrhage in very preterm neonates. Semin Fetal Neonatal Med 2015;20:232\u20137, https:\/\/doi.org\/10.1016\/j.siny.2015.02.004.","DOI":"10.1016\/j.siny.2015.02.004"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_017","doi-asserted-by":"crossref","unstructured":"Alderliesten, T, Lemmers, PM, Smarius, JJ, van de Vosse, RE, Baerts, W, van Bel, F. Cerebral oxygenation, extraction, and autoregulation in very preterm infants who develop peri-intraventricular hemorrhage. J Pediatr 2013;162:698\u2013704.e2, https:\/\/doi.org\/10.1016\/j.jpeds.2012.09.038.","DOI":"10.1016\/j.jpeds.2012.09.038"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_018","doi-asserted-by":"crossref","unstructured":"DeVore, GR. The importance of the cerebroplacental ratio in the evaluation of fetal well-being in SGA and AGA fetuses. Am J Obstet Gynecol 2015;213:5\u201315, https:\/\/doi.org\/10.1016\/j.ajog.2015.05.024.","DOI":"10.1016\/j.ajog.2015.05.024"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_019","doi-asserted-by":"crossref","unstructured":"Stoll, BJ, Hansen, NI, Bell, EF, Walsh, MC, Carlo, WA, Shankaran, S, et al.. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993\u20132012. JAMA 2015;314:1039\u201351.","DOI":"10.1001\/jama.2015.10244"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_020","doi-asserted-by":"crossref","unstructured":"Handley, SC, Passarella, M, Lee, HC, Lorch, SA. Incidence trends and risk factor variation in severe intraventricular hemorrhage across a population based cohort. J Pediatr 2018;200:24\u20139.e3, https:\/\/doi.org\/10.1016\/j.jpeds.2018.04.020.","DOI":"10.1016\/j.jpeds.2018.04.020"},{"key":"2022011210063976388_j_jpm-2021-0142_ref_021","doi-asserted-by":"crossref","unstructured":"Roberge, S, Nicolaides, K, Demers, S, Hyett, J, Chaillet, N, Bujold, E. The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis. Am J Obstet Gynecol 2017;216:110\u201320.e6, https:\/\/doi.org\/10.1016\/j.ajog.2016.09.076.","DOI":"10.1016\/j.ajog.2016.09.076"}],"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2021-0142\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2021-0142\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T10:07:05Z","timestamp":1641982025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2021-0142\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,20]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,8,2]]},"published-print":{"date-parts":[[2022,1,27]]}},"alternative-id":["10.1515\/jpm-2021-0142"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2021-0142","relation":{},"ISSN":["0300-5577","1619-3997"],"issn-type":[{"value":"0300-5577","type":"print"},{"value":"1619-3997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,20]]}}}